Utilidad del dermatoscopio en la correlación clínica e histológica de nevus pigmentados / Usefulness of Dermatoscopy in the clinical and histological correlation of Pigmented Nevi

Introducción: La precisión diagnóstica de los nevus pigmentados ha sido una constante preocupación por los dermatólogos. Objetivo: Identificar la utilidad del dermatoscopio en la correlación de las características clínicas y los patrones dermatoscópicos de nevus pigmentados y su asociación con el diagnóstico histológico. Métodos: Se realizó una investigación observacional, analítica, de tipo correlacional, con pacientes de la zona sur de Ciego de Ávila que acudieron a la consulta de dermatología del Hospital Provincial General Docente Dr. Antonio Luaces Iraola en el periodo de abril 2017 a diciembre 2019. Resultados: Predominó el sexo femenino, el grupo de edad de 21 a 30 años, el fototipo II de piel y la zona expuesta (cara y V del escote) (18 ;35,3 por ciento) sin relación entre estas variables. El diagnóstico histológico de nevus de la unión se encontró asociado a la simetría (p < 0,004), la pigmentación homogénea (p < 0,000), así como al patrón dermatoscópico reticular (p < 0,000), globular (p < 0,002) y homogéneo (p < 0,008). El nevus intradérmico se observó asociado a la característica clínica de pigmentación homogénea (p < 0,007), y al patrón dermatoscópico reticular (p < 0,000) y homogéneo (p < 0,005). El nevus compuesto no presentó relación con las características clínicas ni dermatoscópicas. El nevus azul solo se correlacionó con el patrón dermatoscópico homogéneo (p < 0,025). Conclusión: Los patrones dermatoscópicos fueron útiles para el diagnóstico clínico e histológico de los nevus pigmentados(AU)

Introduction: The diagnostic precision of pigmented nevi has been a constant concern of dermatologists. Objective: To determine the usefulness of the Dermatoscope in the correlation of the clinical characteristics and the dermoscopic patterns of pigmented nevi and their association with the histological diagnosis. Methods: An analytical observational investigation of a correlational type was carried out in patients from the southern area of Ciego de Ávila who attended the Dermatology consultation at the Antonio Luaces Iraola Provincial Hospital in the period from April 2017 to December 2019. Results: The female sex, the age group of 21 to 30 years, skin phototype II and the exposed area (face and V of the neckline) (18; 35.3 percent) predominated with no relationship between these variables. The histological diagnosis of junctional nevus was found associated with symmetry (p <0.004), homogeneous pigmentation (p <0.000), as well as the reticular dermoscopic pattern (p <0.000), globular (p <0.002) and homogeneous (p <0.008). The intradermal nevus was observed associated with the clinical characteristic of homogeneous pigmentation (p <0.007), and with the reticular (p <0.000) and homogeneous (p <0.005) dermoscopic pattern. The composite nevus was not related to clinical or dermoscopic characteristics. The blue nevus only correlated with the homogeneous dermoscopic pattern (p <0.025). Conclusions: The dermoscopic patterns were useful for the clinical and histological diagnosis of pigmented nevi(AU)

Nevo dividido na região genital: relato de seis casos / Divided nevus in the genital region, report of six cases

Os nevos divididos ocorrem em áreas contíguas da pele e, em sua grande maioria, são lesões benignas. Relatamos seis casos de nevo dividido no pênis e seus respectivos padrões dermatoscópicos. Levando em consideração a localização dessas lesões, o acompanhamento clínico foi a melhor opção terapêutica para este grupo de pacientes

The divided nevi occur in contiguous areas of the skin that are mostly benign lesions. We report six cases of nevus divided on the penis and its dermoscopic patterns. Clinical follow-up was the best therapeutic option for this group of patients, considering the location of these lesions.

Intradermal Naevi of External Auditory Canal: Unusual location with a unique presentation

The incidence of intradermal nevus in the externalauditory canal is uncommon. We herein are describing acase of 60-year-old lady who presented with foreign bodysensation in the right external ear canal (EAC) with milddiscomfort and ear bleed during ear picking. Otoscopicexamination revealed hyperpigmented mass on the floorof the outer two third of EAC. Complete excisional biopsyof the mass resulted in histopathology findings ofintradermal nevus. Despite the fact that the disease is notalarming, the possibilities of benign melanocytic nevitransformation into malignant lesions such as melanomaneed to be ruled out.

An Adverse Effect Following Illegal Medical Procedure by Unlicensed Non-medical Personnel / 대한피부과학회지

No abstract available.

Atypical Junctional Melanocytic Hyperplasia with Intradermal Nevus / 대한피부과학회지

Atypical junctional melanocytic hyperplasia is a rare condition with unknown etiology. It is characterized by focal atypical melanocytic proliferation limited in the basal layer. Although this lesion is difficult to separate from melanoma in situ (MIS), it could be distinguished from MIS by the lack of several features, including lateral spread, upward epidermal migration, marked cytologic atypia, finely granular "smoky" melanin pigment, mitotic figures, and a subjacent host inflammatory response. In one study, atypical junctional melanocytic hyperplasia was found in 6.2% (25/400) of otherwise normal intradermal nevi. However, to our knowledge, no case of atypical junctional melanocytic hyperplasia with intradermal nevus has ever been published in Korean dermatologic literatures. Herein, we report a rare and interesting case of atypical junctional melanocytic hyperplasia with intradermal nevus.

Four Cases of Lobulated Intradermal Nevus: A Sign of Aging Melanocytic Nevus

Melanocytic nevi are subject to change with age in both clinical and histopathologic findings. In 1991, Cho et al. first reported three cases of lobulated intradermal nevi and suggested their cases represented an unusual form of regressing melanocytic nevus. Herein we report four cases of lobulated intradermal nevus and review previous literature.

Intradermal Nevus on the Lower Lip / 대한피부과학회지

Melanocytic nevi of the lower lip are rare benign melanocytic tumors. They can be classified in four types (junctional, compound, intradermal, blue). Among these 4 types, the intradermal type (sometimes referred to as intramucosal or subepithelial type) is the most common type. We report here on a case of intradermal nevus that developed on the lower lip of an 87-years old female patient who presented with a 0.8 cm-sized, partially crusted nodule.

A Case of Dysplastic Nevus of the External Auditory Canal Presenting with Conductive Hearing Loss

A nevus which is a benign melanocytic neoplasm rarely occurs within the external auditory canal (EAC). A dysplastic nevus presents atypical features both clinically and histologically, and is important as a potential precursor for melanoma. We present a case of a 33-year-old female patient with a dysplastic nevus in her EAC. Physical examination revealed a protruding mass arising from the posterior wall of the left cartilaginous EAC. The mass showed clinically characteristic findings of a melanocytic nevus. The patient underwent excisional biopsy via a transcanal approach under local anesthesia. Histopathological examination revealed an intradermal nevus with atypical melanocytes without pleomorphism. There was no evidence of recurrence two years after surgical excision.

A Case of Intradermal Nevus Combined with Epidermal Cyst / 대한피부과학회지

The combination of an intradermal nevus with epidermal cyst or other adnexal tumors has often been described since 1952. Most of these reports have involved the coexistence of common epidermal cysts and melanocytic nevi. Herein, we report a 21-year-old Korean male, who initially presented to our department with a rapidly enlarging preexisting nevus on his back. The mass was surgically excised and histopathologically showed intradermal nevus combined with epidermal cyst.

A Case of Neurotized Nevus with Sclerotic Fibroma-like Change / 대한피부과학회지

We report a case of neurotized nevus with a sclerotic fibroma-like change in a 60-year-old female patient, who presented with a brown colored pedunculated nodule on the upper quadrant of the abdomen. The skin biopsy revealed a well-circumscribed, non-encapsulated nodule in the reticular dermis, which consisted of hypocellular hyalinized collagen bundles separated by clefts mixed with nevus cells. Nevus cells are small with a spindle appearance and contain Meissner corpuscle-like structures called nevic corpuscles. We suggest that a sclerotic fibroma-like change is an evolutionary end-point of a pre-existing lesion. This is supported further by the fact that neuroid change in the intradermal nevus represents the end stage of maturation of melanocytes of the nevi.

A Case of Congenital Lobulated Intradermal Nevus / 대한피부과학회지

Lobulated intradermal nevus is a rare subtype which has distinct clinicopathological findings and is similar to a regressing melanocytic nevus. A 22-year-old female presented with a lobulated 6.5 x 8.5 cm sized black plaque on her right shoulder. This had been present since birth and had grown slowly with a darkening change in colour. A skin biopsy revealed a fatty infiltration within the nest of nevus cells, dermal fibrosis and neuroid differentiation of the nevus cells.

Diffuse Congenital Nonpigmented Intradermal Nevus on the Scalp Treated with Tissue Expander / 대한피부과학회지

A 21-year-old man presented with a solitary 14x10cm sized slightly elevated firm plaque with partial hair loss on the right parietal scalp, which he had had since birth. Histopathologic examination revealed typical findings of congenital intradermal nevus. As a preoperative procedure a 300cc capacity crescentic expander was placed under the uninvolved scalp. Inflation and expansion of uninvolved left parietal scalp with saline over a 10-week period allowed excision of a 14x10 cm sized area of medium-sized congenital intradermal nevus. No hematoma or infection of the expanded skin occurred. We, herein, report an unusual case of diffuse congenital, nonpigmented, intradermal nevus with partial alopecia on the scalp, which was successfully treated with complete excision used by tissue expander.

A Case of Intradermal Nevus Clinically Mimicking Periungual Fibroma / 대한피부과학회지

We report a case of intradermal nevus in a 43-year-old female patient, who presented with a tender, solitary papule on the periungual area, which seemed to be a periungual fibroma. The skin biopsy revealed the upper dermis and lower dermis containing nests and cords of nevus cells without junctional activity. It was totally removed by excisional biopsy.

A Case of Cutis Verticis Gyrata due to Cerebriform Intradermal Nevus in the Neonate / 소아과

Cutis verticis gyrata(CVG) is a morphologic syndrome of the scalp characterized by folds and furrows resembling the surface of brain. The primary form of cutis verticis gyrata is commonly associated with a neuropsychiatric condition and a secondary form occurs as a response of inflammatory or neoplastic process. The patient was a 1-day-old girl, who had a 15x11 cm sized, convoluted mass over whole scalp. Skin biopsy from the lesion was consistent with cerebriform intradermal nevus. The baby girl was followed up as an outpatient with monitoring of the scalp lesion for 2 years and showed improvement of folds and furrows of the lesion.

A Case of Congenital Lobulated Intradermal Nevus / 대한피부과학회지

Lobulated intradermal nevus is an unusual form of regressing melanocytic nevus. Clinically, it shows a lobulated plaque and biopsy specimens display fatty infiltration within nests of nevus cells, dermal fibrosis and neuroid differentiation of nevus cells. We report a case of lobulated intradermal nevus resembling linear epidermal nevus in a 45-year-old female patient.

A Case of Intradermal Nevus with Pseudovascular Space / 대한피부과학회지

Melanocytic nevus may be histologically associated with cleft of nests resembling vascular space. This pseudovascular space mainly has been known as an artifact of tissue processing and may simulate the lymphatic invasion of malignant melanoma. It is important to be aware of this histologic variant in melanocytic nevus to prevent the misdiagnosis. We report a 38-year-old female who had a melanocytic nevus on her back since childhood. This nevus gradually enlarged with erythematous swollen border for several months. Histopathologic examination represented an intradermal melanocytic nevus. Nevus cell nests were clustered in the dermis and vascular-like spaces were seen in the nevus cell nests. Immunohistochemical staining showed that cells lining the pseudovascular space were positive for S-100 protein and negative for smooth muscle actin, factor VIII-related antigen, and CD34. We conclude that these spaces are lined by nevomelanocytes and that the spaces are not truly vascular.

A Case of Intradermal Nevus with Seborrheic Keratosis / 대한피부과학회지

A review of the literature indicates that the simultaneous occurrence of two or more neoplasms in one specimen is a relatively infrequent finding. The finding of nevocellular nevi in close association with seborrheic keratosis, desmoplastic trichoepithelioma, syringoma, basal cell carcinoma, trichilemmal cyst, and epidermoid cyst raises interesting points about the histogenesis of these lesions. The combined occurrence of nevus with other epithelial neoplasms may indicate that changes in the microenvironment produced by nevus result in the induction of growth of the ectodermal origin neoplasms. We report a case of simultaneous occurrence of intradermal nevus and seborrheic keratosis.

The Expression of p53 and p21 in Intradermal Nevus, Junctional Nevus and Malignant Melanoma / 대한피부과학회지

BACKGROUND: The function of the p53 protein is known to regulate cell proliferation by inhibiting cells entering S phase, so DNA damaged cell proliferation is inhibited by apoptosis. p21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought to mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 are expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis are important. OBJECTIVE: The purpose of this study was to analyze immunohistochemical expression of mutant p53 and p21 protein in melanocytic lesions. METHOD: 11 cases of intradermal nevus, 7 cases of junctional nevus and 6 cases of malignant melanoma were immunohistochemically stained with p53 and p21 monoclonal antibodies. RESULTS: 1. In intradermal nevus, the p53 was negative in 100% and the p21 was negative in 98%. These findings suggest that the composing cells of intradermal nevus is completely mature cell. 2. The positive rates of p53 and p21 in junctional nevus were 43% and 43%, respectively. The positive rates of p53 and p21 in malignant melanoma were 82% and 67%, respectively. CONCLUSION: If the expression of p21 is induced by p53 independent pathway, the cell cycle can be arrested in G1 phase, so the tumor cell proliferation is inhibited. But if the expressed p21 is mutated as p53, it means that the natural function of p21 disappears. More research is necessary about the nature of p21 which is expressed with mutant p53.

A Case of Intradermal Nevus on the Lower Lip / 대한피부과학회지

We report a case of intradermal nevus in a 52-year-old female patient, who presented with asymptomatic, solitary papule, which had been on the site for years as a macule on the center of the lower lip, which is a rare site for intradermal nevus. The skin biopsy revealed the upper dermis containing nests and cords of nevus cell without junctional activity. The skin lesion was totally removed by surgical excision on biopsy.

A Case of Intradermal Nevus of the External Auditory Canal / 대한이비인후과학회지

While intradermal nevi are common benign pigmented skin tumors, their occurrence within the external auditory canal(EAC) is uncommon. We experienced a case of huge intradermal nevus which almost completely obstructed EAC without accompanying conductive hearing loss. It originated in the anterior wall of cartilaginous portion of EAC. It was treated by en bloc excision with split skin graft. The clinical and pathologic features of the intradermal nevus arising within the external auditory canal are presented, and the literatures were reviewed.