ABSTRACT
We reported a case of hemolytic transfusion reaction producing acute renal failure due to Anti-Jkb in a 35-year-old man with septic hip in post-operative state. At first, he received 7 units of packed red blood cells one month before admission, 2 units for hematuria 7 days before, and with 2 units just one day before the admission. He complained of symptoms and signs accounting for acute hemolytic transfusion reaction with chilling, hematuria, and oliguria. In this case, it seems that the patient acquired unexpected antibody by the episode of transfusion one month ago. He received another transfusion with similar episode of transfusion reaction. His transfusion was repeated and even more severe hemolytic transfusion reaction was presented, leading to acute renal failure.
Subject(s)
Adult , Humans , Acute Kidney Injury , Blood Group Incompatibility , Erythrocytes , Hematuria , Hip , OliguriaABSTRACT
We report a hemolytic transfusion reaction with acute intravascular hemolysis due to anti-Jkb in a 49-year-old woman with uterine myoma. A patient experienced chills, fever, and red color urine following the transfusion of 1.25 units of packed red cells, shown to be compatible by the conventional cross-matching tube method. She had been received two units transfusion 3 weeks ago and there was no transfusion reaction at that time. One day after transfusion, her laboratory data showed total bilirubin 2.7 mg/dL, LDH 2,310 IU/L, and a trace positive direct antiglobulin test. Irregular antibody screening test was negative by the conventional tube methods but anti-Jkb was identified by column agglutination method. The presence of anti-Jkb provided an explanation for the acute hemolytic reaction. The hemolytic transfusion reaction was secondary responses following the previous transfusion. She showed severe hemoglobinuria, but renal failure did not develop and she was fully recovered with maintaining adequate renal output with IV diuretics.