ABSTRACT
The clinical and pathological features of five patients with intraventricular neurocytoma are reported. Distribution among men and women is equal. The patients' age at diagnosis ranged from 20 to 57 years. The lesions were located in the lateral and third ventricles. Raised intracranial pressure was the main cause of the clinical manifestations. An isodense mass with multiple intratumoral cysts and homogeneous contrast enhancement was the characteristic computerized tomographic finding. Cerebral angiography showed homogeneous vascular staining in four patients. Magnetic resonance images revealed a mass isointense with the cerebral cortex on both T1- and T2-weighted images. Gadolinium-diethylenetnaminepenta-acetic acid-enhanced images showed homogeneous enhancement. Total removal of the tumor was performed in five patients. Histologically, all tumors were composed of small uniform cells with perinuclear halo and regular round nuclei. Immunohistochemical studies demonstrated strong positivity for neuron-specif ic enolase in all five cases and for synaptophysin in two cases.
Subject(s)
Female , Humans , Male , Cerebral Angiography , Cerebral Cortex , Diagnosis , Intracranial Pressure , Neurocytoma , Phosphopyruvate Hydratase , Synaptophysin , Third VentricleABSTRACT
The clinical and pathological features of five patients with intraventricular neurocytoma are reported. Distribution among men and women is equal. The patients' age at diagnosis ranged from 20 to 57 years. The lesions were located in the lateral and third ventricles. Raised intracranial pressure was the main cause of the clinical manifestations. An isodense mass with multiple intratumoral cysts and homogeneous contrast enhancement was the characteristic computerized tomographic finding. Cerebral angiography showed homogeneous vascular staining in four patients. Magnetic resonance images revealed a mass isointense with the cerebral cortex on both T1- and T2-weighted images. Gadolinium-diethylenetnaminepenta-acetic acid-enhanced images showed homogeneous enhancement. Total removal of the tumor was performed in five patients. Histologically, all tumors were composed of small uniform cells with perinuclear halo and regular round nuclei. Immunohistochemical studies demonstrated strong positivity for neuron-specif ic enolase in all five cases and for synaptophysin in two cases.
Subject(s)
Female , Humans , Male , Cerebral Angiography , Cerebral Cortex , Diagnosis , Intracranial Pressure , Neurocytoma , Phosphopyruvate Hydratase , Synaptophysin , Third VentricleABSTRACT
A rare case of intraventricular central neurocytoma in 17-year-old male is reported. The patient had diffuse headache and diplopia. Radiologic findings displayed obstructive hydrocephalus and a large, well-demarcated intraventricular mass lesion obstructing the foramen of Monroe. The tumor arouse from the splenium of corpus callosum. It was removed successfully using two different approaches after extraventricular drainage of the cerebrospinal fluid(CSF). Histologically, the tumor showed pathological features as that of oligodengroglioma on the light microscope. In immunohistochemical examination, glial fibrillary acidic protein(GFAP) was negative and synaptophysin, positive. Numerous neurosecretory granules were found and no typical synapsis was noticed on the electron microscope. No shunt operation was needed. Postoperative radiotherapy or chemotherapy was not performed and no tumor recurrence was detected during the one year follow-up period. We present the case together with a review of the literatures.