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Objective:To explore whether the adoption of high-flow nasal cannula (HFNC) as an initial oxygen therapy in emergency department (ED) could reduce the intubation rate and improve the clinical outcomes of patients with dyspnea and hypoxemia compared with conventional oxygen therapy (COT).Methods:A perspective single-center randomized controlled trial was conducted in the First Affiliated Hospital of Zhengzhou University from October 1, 2019 to September 30, 2020. A total of 210 eligible patients with acute dyspnea and hypoxemia in ED were recruited and randomized (in 1:1) to receive HFNC or COT for 1 h immediately after the grouping. The primary outcome was the rate of intubation within 24 h. The secondary outcomes included total intubation rate, escalation of breathing support method, patients’ disposition, length of ICU stay and hospital mortality. Continuous outcomes were analyzed by independent samples t test or Mann-Whitney U test according to the data distribution. Discontinuous outcomes were compared with the Chi-square test. Kaplan-Meier curve analysis was performed for 60-day survival. Results:Finally, 105 patients were recruited in each group. HFNC reduced the intubation rate within the first 24 h (4.8% vs. 14.3%, P = 0.019) and the rate of patients escalated to upgrade oxygen therapy (34.3% vs. 53.3%, P = 0.005), but did not affect the total intubation rate during the whole attendance ( P = 0.509). In ED, HFNC helped more patients to achieve the targeted saturation of pulse oxygen (90.5% vs. 78.1%, P = 0.02), and reduced respiratory rate (RR) to < 25 breaths per min (68.6% vs. 49.0%, P = 0.004), but did not affect the length of hospital stay, hospital mortality and 60-day survival rate ( P > 0.05). Conclusions:Initial application of HFNC in ED could reduce the intubation rate within 24 h, decrease the rate of escalation of oxygen therapy, improve oxygenation and relieve dyspnea.
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Introduction@#Colonoscopy is the cornerstone in diagnosis and management of colorectal disease allowing direct optical diagnosis, tissue sampling for histological analysis and therapy of colonic lesions. It is a multi-step process and therefore assessment of all aspects of the procedure must be addressed. The main aim of the study is to assess the quality of colonoscopy services in the Colonial War Memorial Hospital from 1st January, 2012 to December 2016.@*Methodology@#A 5-year single-centre, retrospective study.@*Results@#A total of 341 colonoscopies were included in the study. Six Quality indicators of colonoscopy which are applicable to our setting were chosen for the study. The study showed a Cecal Intubation rate of 67% is well below the recommended rate of 90%. The bowel preparation quality is adequate in 53% of the cases compared to a recommended rate of 85%. The withdrawal time has not yet been introduced however, an average withdrawal time of above 6 minutes is recommended for a quality colonoscopy. Acquisition of biopsies in diarrhoea patients was 79% (100% tissue acquisition rate was recommended for quality of colonoscopy). @*Conclusion@#The quality of colonoscopy services carried out at the Colonial War Memorial Hospital has room for improvement in the parameters determining the quality of colonoscopies.
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Objective@#To investigate the effect of cough assist on sputum excretion and the outcome of withdrawal of mechanical ventilation after mechanically ventilated chronic obstructive pulmonary disease (COPD) patients with cough weakness.@*Methods@#From January 2017 to December 2018, 74 patients with cough and weakness COPD after extubation of mechanical ventilation in the Department of Respiratory Critical Care Medicine of Hunan Provincial People's Hospital were divided into control group(n=37) and observation group (n=37) according to the random number table method. The patients in the control group were treated routinely after weaning and extubation, and the observation group was treated with cough assist after withdrawal of mechanical ventilation and extubation on the basis of the control group. The differences in drainage effect, blood gas index, reintubation rate and early prognosis index between the two groups were compared.@*Results@#After the intervention treatment, the first active sputum excretion and the total sputum volume on the first day were (5.6±3.4) ml and (33.1±5.2) ml in the observationgroup, and (4.2 ±2.0) ml and (29.1±7.4) ml in the control group, the difference was statistically significant (t=-2.10, 2.875, P<0.05). The number of significant cases of respiratory sound improvement in the observation group and the control group was 21 and 14 cases, respectively, and the difference between the two groups was statistically significant (Z=-1.974, P < 0.05). The oxygen partial pressure (PaO2) and oxygenation index (PaO2/FiO2) carbon dioxide partial pressure (PaCO2) values of the observation group were (80.0±8.4), (345.9±19.2), (46.7±6.6)mmHg, and (74.8±9.1), (310.7±21.9), (50.9±7.1)mmHg in the control group. The difference was statistically significant (t=-2.504,-2.710, 2.579, all P<0.05). The reintubation rate, noninvasive ventilation time, and hospitalization days after the initial extubation in the observation group were as follows: 5.6%(2/36), (64.1±18.9)h, (6.0±1.7)d, and 22.2%(8/36), (76.7±15.3)h, (7.2±2.8)d in the control group. The difference was statistically significant (χ2=4.181, t=2.528, 2.438, all P<0.05). The non-invasive ventilation rate within 72h in the observation group and the control group were 63.9% (23/36) and 75.0% (27/36), the difference was not statistically significant (χ2=0.222, P>0.05).@*Conclusions@#The application of cough assist in RICU patients with cough weakness after extubation by mechanical ventilation can improve the expectoration efficiency of cough, improve oxygenation, reduce carbon dioxide retention, reduce the rate of re-intubation, shorten the time of noninvasive ventilation and hospitalization after extubation, and improve the curative effect.
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Objective To find the related factors of the unsuccessful unsedated colonoscopy. Methods Clinical data of 1 726 consecutive subjects who underwent colonoscopy without sedation from April 2014 to January 2015 at the second affiliated hospital of Soochow university were analyzed. Data included characteristics of the patients (age, gender, body mass index, degree of education, the bowel-cleaning drugs, previous colonoscopy experience, bowel habits, history of chronic disease, history of sport, history of abdominal or pelvic surgery, the indication of colonoscopy, mood, quality of bowel preparation, and presence/absence of colonic diverticulum), the characteristics of the physicians (procedure experience, the instrument handling method). These factors were analyzed to evaluate their impact on result of unsedated colonoscopy. Results This study included 1 726 patients (male/female: 927/799). These patients' average age was 50.04 years old, the cecal intubation rate was 91.6%, and the average intubation time was 10.27 minutes. The multiple regression analysis showed the elderly patient, lower BMI, irritability, consti﹣pation, poor bowel preparation were associated with the lower cecal intubation rate. Conclusions The elderly patient, lower BMI, irritability, constipation and poor bowel preparation were associated with the failure of unsedated colonoscopy. In clinical practice, quality improvement programs are needed to improve the rate of total colonoscopy.
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Introduction: T-piece resuscitator (TPR) has many advantages compared to self-inflating bag (SIB). Early Continuous Positive Airway Pressure (CPAP) during newborn resuscitation (NR) with TPR at delivery can reduce intubation rate. Methods: We speculated that the intubation rate at delivery room was high because SIB had always been used during NR and this can be improved with TPR. Intubation rate of newborn 50%. An audit was carried out in June 2010 to verify this problem using a check sheet. Results: 25 neonates without major congenital anomalies who required NR with SIB at delivery were included. Intubation rate of babies <24 hours of life when SIB was used was 68%. Post-intervention audit (August to November 2010) on 25 newborns showed that the intubation rate within 24 hours dropped to 8% when TPR was used. Proportion of intubated babies reduced from 48.3% (2008-2009) to 35.1% (2011-2012), odds ratio 0.58 (95% CI 0.49-0.68). Proportion of neonates on CPAP increased from 63.5% (2008-2009) to 81.0% (2011-2012), odds ratio 2.44 (95% CI 2.03-2.93). Mean ventilation days fell to below 4 days after 2010. Since then, all delivery standbys were accompanied by TPR and it was used for all NR regardless of settings. There was decline in intubation rate secondary to early provision of CPAP with TPR during NR. Mean ventilation days, mortality and length of NICU stay were reduced. Conclusion: This practice should be adopted by all hospitals in the country to achieve Millennium Development Goal 4 (2/3 decline of under 5 mortality rate) by 2015.
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Infant, NewbornABSTRACT
Aim and Objective: Colonoscopy is generally considered a painful procedure requiring sedation. Due to the high cost of sedation colonoscopy, coupled with the attendant morbidity and mortality, there is a general trend towards unsedated colonoscopy. The aim of this study was to determine the effect of unsedated colonoscopy on the success of caecal intubation, factors predictive of painful procedure and to compare with results elsewhere. Materials and Methods: Forty one consecutive patients who underwent colonoscopy were recruited into this study. The study was carried out at a privately owned low-volume endoscopy centre: Gilead specialist hospital (GSH), Ado-Ekiti, Nigeria from January 2010 to December 2011. Ethical approval for the study was obtained from the centre’s Research and Ethics Committee and all the patients gave their individual written consent. SPSS version 15.0 (SPSS, Inc., Chicago, Illinois, USA) was deployed for statistical analysis using the t-test for quantitative variables and χ2 test for qualitative variables. Differences were considered to be statistically significant if P value was less than 0.05. Results: The male: female ratio was 1.93:1. The mean age of the studied population was 53.20±9.53 years [age range from 30-71. The indications for colonoscopy were; lower gastrointestinal bleeding (41.5%), abdominal pain or discomfort (19.5%), diarrhea (12.2%), suspected cancer [Patients with history of GI bleeds, weight loss, recurrent diarrhoea and ileus (12.2%), constipation (7.3%) and routine examination (7.3%). Overall, caecal intubation was achieved in 70.7% of cases while in 29.3% caecal intubation was unsuccessful. With on demand analgesia, and exclusion of both cases of obstruction (tumors) and poor bowel preparations, caecal intubation rate rose to 94.3%. Causes of unsuccessful caecal intubation included: abdominal pain or discomfort (33.3%), bowel obstruction (25%), poor bowel preparation (16.7%), anxiety (6.6%) and obesity (8.3%). Colonoscopy findings were haemorrhoids (36.6%), polyps (17.1%), colorectal cancer (14.6%), arteriovenous malformations (7.3%), anal fissure (4.9%), inflammatory bowel disease (2.4%) and normal findings (17.1%). Bowel preparation was adjudged adequate in 80.5% (33/41) of the patients. Female gender and abdominal pain as indication for colonoscopy were found to be predictive for painful colonoscopy (p<0.05). Conclusion: Unsedated colonoscopy with on demand analgesia is advocated in resource poor countries to minimize the direct and indirect costs of colonoscopy. It is also recommended to minimize patient burden in screening and surveillance colonoscopy. Colonoscopists are advised to use the warm water (37°C) method in this setting as against the traditional air insufflations to achieve a high success rate of caecal intubation.
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For a complete colonoscopic examination, a high intubation rate and a short intubation time have been demanded to colonoscopists, if possible. The aim of the present study was to compare these examination parameters, intubation time and rate, according to the length of colonoscope. A total of 507 healthy Korean subjects were randomly assigned into two groups: intermediate length adult-colonoscope (n=254) and long length adult-colonoscope (n=253). There were significant differences in cecal intubation time and in terminal ileal intubation rate according to the length of the colonoscope. Time-to-cecal intubation was shorter for the intermediate-scope group than for the long-scope group (234.2 +/- 115.0 sec vs 280.7 +/- 135.0 sec, P < 0.001). However, the success rate of terminal ileal intubation was higher in the long-scope group than in the intermediate-scope group (95.3% vs 84.3%, P < 0.001). There were no significant differences in other colonoscopic parameters between the two groups. The intermediate length adult-colonoscope decreased the time to reach the cecum, whereas the long-scope showed a success rate of terminal ileal intubation. These findings suggest that it is reasonable to prepare and use these two types of colonoscope appropriate to the needs of the patient and examination, instead of employing only one type of colonoscope.