Impact of iodinated contrast agents on blood oxygenation level of renal in rabbits with diabetic nephropathy using BOLD-MRI / 中国医学影像技术

Objective: To evaluate the impact of iodinated contrast media on renal oxygenation content in rabbits with diabetic nephropathy using BOLD-MRI. Methods: Totally 32 rabbits with diabetic nephropathy (experimental group) were randomly divided into 4 groups (each n=8) and received iodinated contrast media with different concentration (200, 240, 300, 350 mgI/ml, named 200 subgroup, 240 subgroup, 300 subgroup and 350 subgroup, respectively). Rabbits in control group (8 normal rabbits) received normal saline (NS). BOLD-MRI was performed at 1, 24, 48 and 72 h after injection, and R2* value of renal cortex, extramedulla and intramedulla of the rabbits were measured and compared among different groups and different time points. Results: One hour after administration of iodinated contrast media, R2* value of the renal cortex, extramedulla and intramedulla increased in experimental group, reaching their peak value at 24 h and then declined. Significant differences of R2* value were found among 4 subgroups at all time points after injection (all P<0.001), and with the increase of iodine concentration, R2* value increased, with the highest R2* value observed in 350 subgroup. In experimental group, R2* value of the extramedulla was higher than the cortex and intramedulla 24 h after injection in 350 subgroup (both P<0.05). Conclusion: Iodinated contrast media can significantly affect the oxygen content of renal extramedulla in diabetic nephropathy rabbits, and the changes may have certain rules. BOLD-MRI can provide auxiliary information for rational clinical application of contrast agent and monitoring renal function.

Levothyroxine versus levothyroxine with iodine in reduction of thyroid nodule volume: a double-blind randomized controlled trial

@#<p><strong>Objective: </strong>To compare levothyroxine alone and in combination with iodine on thyroid nodule volume reduction.</p><p><strong>Methods: </strong></p><p><strong>Design:           </strong>Double-Blind Randomized Controlled Trial</p><p><strong>Setting:           </strong>Tertiary Government Hospital</p><p><strong>Participants: </strong>Nineteen (19) euthyroid patients age 19-54 with at least 1 cytologically benign thyroid nodule were randomized to receive either levothyroxine + iodine or levothyroxine + placebo, taken once a day for 6 months with ultrasound and thyroid stimulating hormone monitoring on the 3rd and 6th month of intervention.</p><p><strong>Results: </strong>Main outcome measures included thyroid nodule volume reduction after six months of intervention. The mean change in volume from baseline to six months of levothyroxine + iodine group showed no statistically significant difference in nodule volume across time between  levothyroxine + placebo group, -0.010 ± 1.250 (CI -0.521 - 0.501) versus 0.507 ± 1.128 (CI 0.025 - 0.990), p=.158.  There were also new nodules (4 nodules) in the placebo group and none in the iodine group. No major adverse events were noted during the study.</p><p><strong>Conclusion: </strong>The two groups did not significantly differ in terms of nodule volume reduction.</p><p><strong>Keywords:</strong> thyroid nodule, prevention and control; drug therapy; iodine compounds, therapeutic use; levothyroxine, therapeutic use</p>

Clinical effect of minimally invasive painless Carisolv iodide removal technique in the treatment of dental caries / 中国基层医药

Objective To investigate the clinical effect of minimally invasive painless iodide removal technique in the treatment of dental caries.Methods From January 2017 to October 2017,60 patients with dental caries in Xiaogang Hospital of Beilun District were selected and divided into observation group(n=50)and control group(n=50).The patients in the control group were treated by traditional dental drill dehumidification technique,and the patients in the observation group were treated by minimally invasive painless iodide removal technique.The clinical effects of the two groups were compared and analyzed.Results The total effective rate,the severe pain during treatment and the slight pain sensation of the observation group were 94％,0％,14％,respectively,which were better than those of the control group(72％,10％,46％),the differences between the two groups were statistically significant(χ2 =11.254,5.011,9.451,all P<0.05).Conclusion The use of Carisolv iodine can reduce the use of anesthetic,or reduce the necessity of using the needle,which can reduce the pain and discomfort of the patients.There is a choice to remove caries,will not damage the normal dental tissue,can reduce the occurrence of complications,which can prolong the life of teeth and reduce the probability of infection,thus to prevent tissue around the tooth from being damaged.

Uso de iodóforo tópico em feridas agudas: [revisão] / Use of topic iodine in acute wounds: [review]

Esta pesquisa objetivou realizar revisão sistemática da literatura relacionada ao uso de iodóforos tópicos no tratamento de feridas agudas. Os ensaios clínicos foram localizados por meio da Base de Dados Cochrane, utilizando-se os seguintes descritores: iodine, acute wound, treatment, healing, infection, surgery, surgical. Vinte (52,6 por cento), dentre 38 artigos, enquadraramse nos critérios de inclusão, sendo analisados quanto às características dos periódicos e dos estudos e classificados em: iodóforo versus outros agentes tópicos (4/ 20 por cento); iodóforo versus coberturas (1/ 5 por cento); iodóforo versus soro fisiológico (5/ 25 por cento); iodóforo versus sem iodóforo (8/ 40 por cento) e iodóforos em diferentes concentrações (2/ 10 por cento). Resultados favoráveis para os iodóforos ocorreram em 45 por cento dos artigos. Quanto às tendências dos resultados, três dentre cinco artigos mostraram-se favoráveis para a cicatrização de feridas e prevenção de infecção e nove dentre 15 artigos foram desfavoráveis ao uso de iodóforos tópicos quando somente a prevenção de infecção foi investigada.

The purpose of this study was to carry out a systematic review of the literature regarding the use of topic iodine and/or compounds in the treatment of acute wounds. The clinical trials were searched at the Cochrane's database using the following descriptors: iodine, acute wound, treatment, healing, infection, surgery, surgical. Twenty studies (52.6 percent) out of 38 met the criteria for inclusion. The articles were analyzed regarding journal and study characteristics and classified into five groups: iodine versus other topic agents (4/ 20 percent); iodine versus types of dressings (1/ 5 percent); iodine versus saline solution (5/ 25 percent); iodine versus no iodine (8/ 40 percent); and iodine at different concentrations (2/ 10 percent). Favorable results for the use of iodine and/or compounds occurred in 45 percent of the studies. Three out of 5 studies showed favorable results for healing and prevention of infection and 9 out of 15 studies were not favorable when only infection prevention was investigated.

En esta investigación se tuvo como objetivo realizar una revisión sistemática de la literatura respecto a la utilización del yodo tópico y/o compuestos en el tratamiento de las heridas agudas. Los ensayos clínicos fueron localizados por medio de la Base de Datos Cochrane, utilizándose los siguientes descriptores: iodine, acute wound, treatment, healing, infection, surgery, surgical. Veinte (52,6 por ciento), de 38 artículos, se encuadraron en los criterios de inclusión, siendo analizados en cuanto a las características de los periódicos y de los estudios y clasificados en: yodo versus otros agentes tópicos (4/ 20 por ciento); yodo versus apósitos (1/ 5 por ciento); yodo versus solución fisiológica (5/ 25 por ciento); yodo versus sin yodo (8/ 40 por ciento) y yodo en diferentes concentraciones (2/ 10 por ciento). Resultados favorables para el yodo se obtuvieron en el 45 por ciento de los artículos. En cuanto a las tendencias de los resultados, tres de cinco artículos se mostraron favorables para la cicatrización de heridas y prevención de infección y nueve de 15 artículos fueron desfavorables al uso del yodo tópico cuando sólo la prevención de infección fue investigada.

Topical iodophor use in chronic wounds: a literature review

This study aimed to do a review of the literature regarding the use of topic iodine and/or compounds in the treatment of chronic wounds. The clinical trials were searched in the Cochrane database. Fourteen (58.3 percent) among 24 studies fulfilled the inclusion criteria. The articles were analyzed regarding journal and study characteristics and classified into three groups: Iodine versus other topic agents (7/ 50 percent); Iodine versus different dressings (6/ 42.9 percent); Iodine versus without Iodine (1/ 7.1 percent). Favorable results for the use of Iodine or similar product occurred in 50 percent of the analyzed studies. Six out of 8 trials showed favorable results for healing and infection prevention/ treatment; 4 out of 5 were not favorable when the healing objective was investigated and 1 study for infection treatment showed no favorable result.

La investigación trata de una revisión de la literatura a cerca de la utilización del yodo tópico y/o compuestos en el tratamiento de las heridas crónicas. Se buscaran los ensayos clínicos en el Cochrane. Catorce (n=24) publicaciones estaban de acuerdo con los criterios de inclusión, y fueran analizadas según las características de las revistas y ensayos y clasificadas como: yodo versus otros agentes tópicos (7/ 50 por ciento); yodo versus curativos (6/ 42,9 por ciento) y yodo versus sin yodo (1/ 7,1 por ciento). Fueran obtenidos resultados favorables a la utilización del yodo y/o compuestos en 50 por ciento de los artículos analizados. Cuanto a las tendencias de los resultados, 6 de 8 publicaciones, a cerca de la de cicatrización de las heridas y prevención de infección, fueran favorables; 4 de 5 fueran no favorables solamente para la cicatrización, y el resultado del único trabajo con indicación del uso para tratamiento de infección de herida fue no favorable.

Trata-se de revisão de literatura relacionada ao uso de iodóforos tópicos no tratamento de feridas crônicas. Os ensaios clínicos foram localizados por meio da Base de Dados Cochrane de Revisões Sistemáticas e Registro Cochrane Central de Ensayos Controlados. Quatorze (58,3 por cento), dentre 24 artigos, atenderam os critérios de inclusão, analisados quanto às características dos periódicos e dos estudos e classificados em três grupos: iodóforo versus outros agentes tópicos (7 ou 50 por cento); iodóforo versus coberturas (6 ou 42,9 por cento) e iodóforo versus sem iodóforo (1 ou 7,1 por cento). Resultados favoráveis à utilização dos iodóforos ocorreram em 50 por cento dos artigos analisados. Quanto às tendências dos resultados, seis, dentre oito artigos, que tratavam de cicatrização de feridas e prevenção de infecção, foram favoráveis; quatro, dentre cinco, foram desfavoráveis somente para a cicatrização e no único ensaio em que houve indicação do seu uso para tratamento de infecção de ferida o resultado foi desfavorável.

Nodular hepatocellular carcinoma: treatment with intraarterial injection of I-131 Lipiodol

Twenty four patients with hepatocellular carcinoma who refused surgery or had unresectable tumor ranging 2.5 to 8.0 cm in size were treated with intrahepatic arterial injection of iodine-131-labeled iodized oil (I-131 Lipodol) in an attempt to achieve internal radiation of tumor. 555-2,220 MBq in 3-8 ml of I-131 Lipiodol was injected into the hepatic artery or proximal to the tumor feeding vessel depending on the tumor size. Tumor size reduction was observed in 88.9% of tumor smaller than 4.0 cm in diameter, 65.5% between 4.1 to 6.0 cm, and 25.0% of larger than 6.1cm, respectively. The tumor size reduction was corresponded to the gradual drop of serum AFP levels, decreased uptake on gallium-67 scintigraphy, and devascularization on follow-up angiography. Tumors having significant A-V shunts revealed further tumor growth. Adverse reactions from the treatment include fever, mild abdominal pain, nausea and elevation of transaminases. These have been mild and well-tolerated by the patients. This method was able to provide long term local control without complications related to thyroid, lung, GI tract and bone marrow.