Constellation of Oral Inflammatory Hyperplastic Lesions: Case Series with Review of Literature

Oral cavity, when subjected to various forms of chronic insults or microtrauma, often results in a hyperplastic lesion, commonly referred to as inflammatory reactive hyperplasia. This category includes various lesions such as peripheral fibroma, peripheral ossifying/cementifying fibroma, pyogenic granuloma, and peripheral giant cell granuloma. They are primarily seen to develop in close proximity to the source of chronic irritant and have a close resemblance in terms of biological behavior and clinical presentation. Histopathologically, they display a common feature of hyperplastic fibrous tissue, but also have some variations like the presence of giant cells or aggregate of calcified mass depending on the histogenesis of the lesion. They were the most common tumor-like lesions to be seen in the oral cavity, familiarity with these lesions are of utmost importance. The present article portrays a series of 5 cases of different clinical forms of reactive hyperplasia with a brief literature review. The current manuscript is presented with an aim to enhance the knowledge about hyperplastic lesions.

Gigantic reactive lesion of mandibular gingival tissue / Lesión gigante reactiva del tejido gengival mandibula

Irritation fibroma are the most common form of reactive lesions found within the oralcavity. These lesions normally attain a small size and show a slow growth rate. This paper reports a case ofgigantic intraoral irritational fibroma with a history of rapid growth. Complete excision was performed andthe specimen was sent for immunohistochemistry (IHC) staining. It was found positive for vimentin, hencereported as irritation fibroma.

Los fibromas irritativos son las forma más común de lesiones reactivas encontradas en la cavidad oral. Estas lesiones normalmente son de pequeño tamaño y muestran una tasa de crecimiento lenta. Este artículo reporta el caso de un fibroma irritativo gigante intraoral con historia de crecimiento rápido. Se realizó la extirpación completa y fue enviado para análisis inmunohistoquímico. Arrojó positivo para Vimentina, por lo tanto, se reportó como fibroma irritativo.

Granuloma piógeno de presentación inusual: Reporte de caso

El granuloma piógeno se considera una lesión reactiva, que surge en respuesta a variados estímulos. Su etiología más común es el trauma y se asocia a higiene oral deficiente. De tamaño variable, la mayoría de los casos asintomáticos y es común su desarrollo en encía. Principalmente se asocia a mujeres jóvenes, en la segunda década de vida, posiblemente debido a un efecto vascular mediado por cambios hormonales. Se presenta el caso de una paciente de 22 años, que presenta una lesión de 10 años de evolución, dolorosa, en encía en relación con los dientes 1.1 a 1.4, la cual clínicamente era compatible con fibroma. Se dispuso una biopsia excisional, y el diagnóstico histológico fue un granuloma piógeno fibrosado. Al control postquirúrgico, se apreció cicatrización excelente, asintomático y sin signos de recidiva posterior a un año de control. El diagnóstico definitivo fue dado mediante estudio histopatológico, lo que indica la vital importancia de este tipo de exámenes cada vez que se realiza la extirpación de alguna lesión. El granuloma piógeno no se puede considerar como una neoplasia verdadera, sino como una lesión reactiva que va modificándose con el tiempo y va variando su estructura.

Pyogenic granuloma is considered as a reactive lesion, which is produced as a response to various stimuli. Its most common cause is trauma which is associated with poor oral hygiene. Resizable, most asymptomatic cases and are common developed in gum. It is mainly associated to young women, during the second decade of life, possibly due to a vascular effect mediated by hormonal changes. A 22-year-patient is presented, with an injury of 10 years of evolution, painful, in gum relative to the teeth 1.1 to 1.4, which was clinically suitable to fibroma. An excisional biopsy was indicated, with the histological diagnosis, and it resulted in a fibrotic pyogenic granuloma. In the post surgical control, wound healing was excellent, asymptomatic and without signs of recurrence after one year of monitoring. The definitive diagnosis was given by a histopathological study, which indicated the vital importance of these tests each time a removal of injury is made. Pyogenic granuloma can not be considered as a true neoplasm but as a reactive lesion, that evolves over time and is changing its structure.

Adenocarcinoma NOS de glándula salival menor en paladar: Reporte de un caso clínico

El adenocarcinoma no especificado o adenocarcinoma NOS de glándula salival, como comúnmente se le llama por sus siglas en inglés "Not Otherwise Specified", es un tipo de neoplasia que no cumple con los requisitos histológicos establecidos para lograr categorizarla dentro de los tumores que afectan las glándulas salivales. A causa de que son muy poco frecuentes, se ha dificultado su estudio, y el conocimiento que se tiene sobre esta entidad es escaso. El objetivo del presente artículo es el de reportar el caso de un paciente masculino de 68 años de edad, quien desarrolla un adenocarcinoma NOS a partir de una glándula salival menor a escala del paladar. Se detalla el alcance que tiene este tipo de patología en cuanto a la invasión, destrucción y alteración que puede generar localmente en el paciente, así como su comportamiento bajo la radio y quimioterapia.

Adenocarcinoma NOS of a minor salivary gland is a type of tumor that does not meet the histological requirements that it needs to be categorized within other salivary gland tumors. Because of their infrequency, there is little known about these tumors. The aim of this paper is to report the case of a 68 years old male patient, who developed an adenocarcinoma NOS arising from a minor salivary gland in the palate. The local invasion and destruction, as well as its behavior under radio and chemotherapy is discussed.

Fibro-epithelial Polyp - Report of Two Cases with Literature Review.

Irritation fibroma or traumatic fibroma is a common sub-mucosal response to trauma from teeth or dental prosthesis presenting as a painless, sessile or occasionally pedunculated swelling that can be firm and resilient or soft and spongy in consistency. It rarely occurs before the fourth decade and shows no preference for either sex. Its occurrence corresponds with intraoral areas that are prone to trauma such as the tongue, buccal mucosa and labial mucosa. As the lesion occurs due to continuous trauma and irritation, it important to remove the source of the irritation and then treat it by conservative surgical excision otherwise it will recur.

Two Cases of Irritation Fibromas on Lower Lip / 대한피부과학회지

Irritation fibroma, also known as traumatic fibroma or focal fibrous hyperplasia, is the most common soft tissue exophytic lesion occurring in the oral cavity. It is a reactive lesion, caused mostly by chronic trauma to the oral mucous membranes. There is no gender or racial predilection, and the most common sites for irritation fibromas are the buccal and labial mucosa and the lateral surface of the tongue. Typical lesion presents as smooth, dome-shaped or pedunculated nodule with color of surrounding mucosa. Histopathologically, irritation fibromas are characterized by their dome shape with a keratinized stratified squamous epithelium, dense bundles of collagen fibers, spindle- or fibroblast-like cells, relatively few blood vessels and inflammatory cells in the submucosa. Although dermatologist should have interest in irritation fibromas due to their higher prevalence, there have been few reports in dermatologic literatures. Herein, we report two cases of multiple irritation fibromas on the lower lip, following lip biting.

Two Cases of Irritation Fibromas on Lower Lip / 대한피부과학회지

Irritation fibroma, also known as traumatic fibroma or focal fibrous hyperplasia, is the most common soft tissue exophytic lesion occurring in the oral cavity. It is a reactive lesion, caused mostly by chronic trauma to the oral mucous membranes. There is no gender or racial predilection, and the most common sites for irritation fibromas are the buccal and labial mucosa and the lateral surface of the tongue. Typical lesion presents as smooth, dome-shaped or pedunculated nodule with color of surrounding mucosa. Histopathologically, irritation fibromas are characterized by their dome shape with a keratinized stratified squamous epithelium, dense bundles of collagen fibers, spindle- or fibroblast-like cells, relatively few blood vessels and inflammatory cells in the submucosa. Although dermatologist should have interest in irritation fibromas due to their higher prevalence, there have been few reports in dermatologic literatures. Herein, we report two cases of multiple irritation fibromas on the lower lip, following lip biting.

Four Cases of Irritation Fibroma / 대한피부과학회지

Irritation(traumatic) fibroma is one of the most common soft-tissue lesions in the oral cavity and represents a reactive fibrous hyperplasia. It is usually found in adults, and sites of trauma such as the buccal and labial mucosa and tongue are commonly involved. The lesion usually present as smooth, dome-shaped or pedunculated nodules with pale pink color or color of surrounding mucosa. We report four cases of irritation fibroma. The patients were all women and in their teens, fifties, and sixties. The lesions were located in labial and buccal mucosa and tongue. Interestingly, we found HPV type 1a in one of them using polymerase chain reaction. The lesions were excised and there has been no recurrence. It is a less known disease among dermatologists despite its high prevalence. We think that this is the first report of irritation fibroma in Korean dermatologic literature.