Expression of heat shock protein 70 and its significance in cerebral ischemic tolerance induced by focal ischemic preconditioning in rats / 临床神经病学杂志

Objective To investigate the influence of focal ischemic preconditioning on the expression of heat shock protein 70(HSP70) and ischemic tolerance Methods 42 SD rats were divided into 3 groups in which control group received sham operation only, and the other two groups received 2 hours of middle cerebral artery occlusion(MCAO) followed by 22 hours of reperfusion with or without 10 minutes of ischemic preconditioning 3 days before Infarct volume and HSP70 immunoreactivity were evaluated in each group Results Compared with the sham operated group, there was a smaller infarct volume( P