ABSTRACT
Objective: To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine. Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature. Results: The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC50 of 8.2 and 8.7 μg/mL, respectively. Conclusions: The research lends support to the ethnomedicinal use of the plant in combating microbial infections, leishmaniasis and malarial infections.
ABSTRACT
OBJECTIVE@#To evaluate the phytochemical, antimicrobial and insecticidal properties of different extracts of Jatropha multifida (J. multifida) in Mauritius.@*METHODS@#Qualitative and quantitative methods were used for the determination of the presence of phytochemicals in the crude solvent extracts of J. multifida. The antimicrobial sensitivity (disc diffusion method) and antibacterial activity (microdilution method) of 13 microorganisms were reported. The insecticidal properties of the crude solvent extracts were tested against the larvae of two insects, Bactrocera zonata and Bactrocera cucurbitae (Diptera: Tephritidae), which cause important economic losses to local fruits.@*RESULTS@#Ethyl acetate was proved to be a good solvent for extraction. J. multifida showed very interesting activity against Bacillus algicola and Staphylococcus epidermis. The plant also showed good larvacidal activity against Bactrocera zonata.@*CONCLUSIONS@#This paper reports the dual use of J. multifida, hence further studies can be made in term of application.
ABSTRACT
Objective: To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine. Methods: The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature. Results: The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC
ABSTRACT
Objective: To evaluate the phytochemical, antimicrobial and insecticidal properties of different extracts of Jatropha multifida (J. multifida) in Mauritius. Methods: Qualitative and quantitative methods were used for the determination of the presence of phytochemicals in the crude solvent extracts of J. multifida. The antimicrobial sensitivity (disc diffusion method) and antibacterial activity (microdilution method) of 13 microorganisms were reported. The insecticidal properties of the crude solvent extracts were tested against the larvae of two insects, Bactrocera zonata and Bactrocera cucurbitae (Diptera: Tephritidae), which cause important economic losses to local fruits. Results: Ethyl acetate was proved to be a good solvent for extraction. J. multifida showed very interesting activity against Bacillus algicola and Staphylococcus epidermis. The plant also showed good larvacidal activity against Bactrocera zonata. Conclusions: This paper reports the dual use of J. multifida, hence further studies can be made in term of application.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.</p><p><b>METHODS</b>The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature.</p><p><b>RESULTS</b>The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC50 of 8.2 and 8.7 µg/mL, respectively.</p><p><b>CONCLUSIONS</b>The research lends support to the ethnomedicinal use of the plant in combating microbial infections, leishmaniasis and malarial infections.</p>