ABSTRACT
Objective: To observe the effect of traditional Chinese medicine Jiusuyu(酒速愈) on activities of superoxide dismutase(SOD) and catalase(CAT),as well as the content of malondialdehyde(MDA) in liver tissues of mice with acute alcoholism.Methods: The models of acute alcoholism mice were established by drinking 56% Hongxing Erguotou(红星二锅头) drink.Eighty healthy Kunming mice were randomly divided(into) normal group,model group,high Jiusuyu dosage group,low Jiusuyiu dosage group and Gehua Jiecheng decoction(葛花解酲汤) group,with 16 animals in each group.The SOD,CAT activities and the content of MDA in(liver) tissues of each group were detected 6 hours after treatment.Results: The content of MDA in(liver) tissues of the model group was increased(P
ABSTRACT
Objective: To investigate the protective effect and its mechanisms of Jiusuyu on gastric mucosa of acute alcoholism mice.Methods: Acute alcoholism mouse models were set up by intragastric administration of 56? Hongxing Erguotou wine,compared with Gehuajiecheng liquid,the effect of Jiusuyu on gastric mucosa pathological histology,SOD、MDA、NO and ET-1 of acute alcoholism mice were observed.Results: The gastric mucosa of mice in model group appeared obvious bleeding,fester and ulcer;a lot of phlegmonosis cells infiltrating could be seen below mucosa.At the same time the activity of SOD and level of NO in gastric mucosa were decreased(P