ABSTRACT
Objective To explore the relationship between polymorphisms of XbaI and MspI loci of apolipoprotein B (ApoB) gene and -75 bp,+83 bp loci of apolipoprotein AI (ApoAI) gene and coronary heart disease (CHD) in Kazaks of Xinjiang Uyghur Autonomous Region,China.Methods These loci were analyzed by PCR-restriction fragment length polymorphism (PCR-PFLP).Two hundred and five patients with CHD and two hundred and thirty six controls were involved.Results There were significant distinctions among low-density lipoprotein cholesterol (LDL-C),triglyceride (TG) and the ApoAI/ApoB ratio between the two groups,but no significant distinction among the polymorphism frequencies of the four sites between the two groups.The polymorphism coalition frequency of X-/Ms++/M1+-/M2++ (named Coalition 11) was significantly higher in CHD compared to the control group (14.6％ vs.7.2％,P ＜ 0.05).The level of total cholesterol (TC) in Coalition 1 1 was significantly higher and the level of the ApoAI/ApoB ratio in Coalition 11 was significantly lower than Coalition 1～10 in CHD patients.The level of the ApoAI/ApoB ratio of Coalition 11 was significantly lower than the Coalition 1～10 in control group.The levels of ApoAI/ApoB ratio of Coalition 3 were significantly higher compared to Coalition 11 in the two groups,respectively.The level of LDL-C of Coalition 3 was significantly lower than in the Coalition 11 in control group.The level of TC of Coalition 5 was significantly higher than Coalition 3 in the CHD group.The level of the ApoAI/ApoB ratio of Coalition 5 was significantly lower than in Coalition 3 or Coalition 1～10 of the two groups,respectively.The level of LDL-C of Coalition 5 was significantly higher than in Coalition 3 in control group.The ratio of ApoAI/ApoB was negatively related to TC,LDL-C and was positively related to HDL-C,both in CHD and control groups.Conclusion Coalition 11 of the 4 loci polymorphisms of the ApoB and ApoAI genes was correlated with CHD in Kazaks,and perhaps the ratio of ApoAI/ApoB was the most diagnostic parameter related with CHD among all lipid parameters.CHD may also be associated with Coalition 5,and,perhaps,Coalition 3 may have been confirmed as a protection factor against CHD,if more samples were enrolled.
ABSTRACT
ObjectiveTo investigate the prevalence and distributing feature of atrial fibrillation (AF) in Xinjiang Kazaks adult population.MethodsFour-stage selected random samples aged 30-89 years from Tacheng,Yili and Aletai were analyzed.An epidemical study of AF was performed including inquiring medical history,recording electrocardiogram and auscultation. ResultsA total of 22 514 adults were surveyed.The prevalence of AF in Xinjiang Kazaks adult population was 0.37％,which was increasing with aging.The prevalence was higher in men than in women (0.5％ vs 0.2％,P ＜0.01 ).In AF patients,23 was valvular AF.Ischemic stroke was the most frequent type and the stroke rate in the patients with AF was significantly higher than that without AF (6.0％ vs 1.2％,P ＜ 0.01 ).ConclusionsThe prevalence of AF in Xinjiang Kazaks adult population is lower than the reported national prevalence but patients with AF in this population would not like to take the necessary medicine. Therefore,the control of AF need to be reinforced.
ABSTRACT
Objective To investigate the prevalence and associated risk factors of type 2 diabetes mellitus in populations of Uigurs and Kazaks in Xinjiang.Methods Four-stage selected random samples aged 35 years and over were used to analyze the prevalence and associated risk factors of type 2 diabetes mellitus in populations of Uigurs and Kazaks from 6 localities(Urumqi,Kelamayi,Fukang,the Turfan Basin locality,Hetian locality,Yili Hazakh autonomous prefecture)in Xinjiang according to different nationality,age,and sex.The data were collected according to questionnaire,and physical examination and laboratory test were performed.Results A total of 8 539 Uigurs and Kazaks adults were surveyed.The prevalences of type 2 diabetes mellitus were 5.01%and 3.16%in Uigurs and Kazaks.The prevalence in male was higher than that in female(5.22%vs3.89%,P75 yeats of age groups,respectively.Age,gender,nationality,systolic blood pressure,body weight,triglyceride,and total cholesterol were the risk factors for type2 diabetes mellitus,with the ORs being0.742,1.025,0.673,1.050,1.005,1.517,1.126,respectively.Conclusion It is important to culture healthy life style,enhance the control of hypertension and hyperlipidemia in Uigurs and Kazaks patients for preventing type 2 diabetes mellitus in Xinjiang.