Queratoquiste recidivante: Experiencia clínica aplicando diversos métodos de tratamiento. Reporte de dos casos / Recurrent Keratocyst: Clinical experience applying diverse treatment methods. Two Case reports

El queratoquiste odontogénico es una lesión intraósea, que surge de restos de la lámina dental y células basales de la mucosa que lo recubre. Ocurre con mayor frecuencia entre la segunda y tercera década de vida, con una incidencia entre el 5 al 14% de todos los quistes odontogénicos; su recidiva varía según el tratamiento, llegando a ser del 23% solo con la enucleación. El objetivo de este artículo es reportar dos casos de queratoquiste con diferentes terapias de tratamiento en queratoquistes recidivantes (marsupialización, descompresión y uso del 5-fluororuracilo); divulgamos este informe debido a la importancia de tratamientos no invasivos con terapias adyuvantes que disminuyen la recidiva en pacientes con queratoquiste.

The odontogenic keratocyst is an intraosseous lesion that arises from remains of the dental lamina and basal cells of the overlying mucosa. It occurs most frequently between the second and third decade of life, with an incidence between 5 to 14% of all odontogenic cysts; its recurrence varies according to the treatment, reaching 23% only with enucleation. The aim of this article is to report two cases of keratocyst with different treatment therapies in recurrent keratocyst (marsupialization, decompression and use of 5-fluoruracil); we disclose this report due to the importance of non-invasive treatments with adjuvant therapies that reduce recurrence in patients with keratocyst.

Tratamiento quirúrgico conservador como primera línea de manejo del queratoquiste. Presentación de un caso / Conservative Surgery as First-Line Treatment for Keratocyst: A Case Report / Tratamento cirúrgico conservador como primeira linha de tratamento do queratocisto. Relato de um caso

Introducción: el queratoquiste hace parte de los quistes odontogénicos del desarrollo, derivado de los residuos de la lámina dental con un comportamiento biológico similar al de una neoplasia benigna. Presenta un alto grado de recidiva y agresividad, con lo que ocasiona una destrucción ósea masiva. Puede aparecer en cualquier zona de los maxilares y estar relacionado con dientes retenidos. Imagenológicamente, presenta una lesión radiolúcida multilocular o poliquística, que muestra un borde cortical delgado. Objetivos: demostrar la importancia de un diagnóstico correcto, una detección temprana y acertada, así como inferir la necesidad de utilizar la solución de Carnoy como primera línea de tratamiento, y determinar el momento oportuno para hacerlo. Presentación de caso: hombre de 34 años de edad, sin antecedentes personales relevantes. Tres años atrás había presentado una lesión radiolúcida localizada en los órganos dentarios 34 y 35, motivo por el que le realizaron endodoncia de estos y le removieron la lesión. Ocho meses después, en la tomografía Cone Beam, se evidenció una lesión hipodensa de mayor tamaño que las iniciales en la hemiarcada inferior izquierda. Conclusión: la marsupialización, enucleación más adyuvancia, así como la correcta evaluación de las características clínicas, radiográficas e histopatológicas, permitieron que se llevara a cabo un tratamiento quirúrgico más conservador sin utilizar la solución de Carnoy. Aun así, siempre se recomienda un seguimiento postoperatorio a largo plazo. Por otra parte, no se descarta el uso de solución de Carnoy en casos aislados y según el criterio del operador

Introduction: Keratocyst is a developmental odontogenic cyst originating from dental lamina residues. Its biological behavior is similar to that of a benign neoplasm. Furthermore, it is aggressive and has a high recurrence rate, causing massive bone destruction. It can appear in any area of the jaw and is associated with impacted teeth. On imaging, it appears as a multilocular or polycystic radiolucent lesion with a thin cortical border. Objective: To show the importance of a precise diagnosis, an early and accurate detection, and to determine the use and appropriate time of the application of Carnoy's solution as first-line treatment. Case presentation: A 34-year-old man, with no relevant personal history, who 3 years ago presented with a radiolucent lesion located at the level of teeth 34 and 35. He under- went endodontic treatment and lesion removal. Approximately 8 months later, cone-beam computed tomography revealed a hypodense lesion larger than the initial lesion at the level of the lower left hemi- arch. Conclusion: Marsupialization; enucleation along with adjuvant therapy; and correct evaluation of clinical, radiographic, and histopathological characteristics enabled a conservative surgical treatment to be performed without using Carnoy's solution; nevertheless, postoperative follow-up is recommended. However, in the long term, the use of Carnoy's solution is not eliminated in isolated cases and will be based on the operator's criteria.

Introdução: o queratocisto faz parte dos cistos odontogênicos de desenvolvimento, derivados dos resíduos da lâmina dentária com comportamento biológico semelhante ao de uma neoplasia benigna. Apresenta alto grau de recidiva e agressividade, causando destruição óssea maciça. Pode aparecer em qualquer área dos maxilares, e estar relacionado a dentes retidos. Por meio de análise de imagem, apresenta uma lesão radiolúcida multilocular ou policística que mostra uma borda cortical fina. Objetivo: demonstrar a importância de um diagnóstico correto, uma detecção precoce e correta, bem como inferir a necessidade de usar a solução de Carnoy como primeira linha de tratamento e determinar o momento oportuno para fazê-lo. Apresentação do caso: paciente do sexo masculino, 34 anos, sem antecedentes pessoais relevantes, apresentou há 3 anos uma lesão radiolúcida localizada ao nível dos órgãos dentários 34 e 35, pelo que foi realizada endodontia nos mesmos e retirada da lesão. Depois de 8 meses, a tomografia Cone Beam revelou uma lesão hipodensa maior que as iniciais ao nível da hemiarcada inferior esquerda. Conclusão: a marsupialização, enucleação mais adjuvante, bem como a correta avaliação das características clínicas, radiográficas e histopatológicas permitiram a realização de um tratamento cirúrgico mais conservador sem o uso da solução de Carnoy, mesmo assim, um acompanhamento pós-operatório é sempre recomendado. Já a longo prazo, não está descartada a utilização da solução de Carnoy em casos isolados e a critério do cirurgião

Reconstrucción mandibular con cortical autóloga auto trasplantada del sitio quirúrgico en queratoquiste, revisión de literatura y reporte de caso / Mandibular reconstruction with autologous cortical bone transplanted from the surgical site in keratocyst, literature review, and case report

El queratoquiste es un quiste odontogénico en el cual se describen diferentes opciones terapéuticas tanto conservadores como agresivas, con diferentes tasas de éxito y recidivas. Dependiendo del tratamiento, las técnicas más agresivas presentan mejores resultados, pero involucran un mayor defecto óseo en la zona tratada versus las técnicas conservadoras. El propósito de este reporte de caso es documentar una técnica quirúrgica utilizada en un paciente masculino de 17 años que, tras un tratamiento descompresivo de 8 meses, fue sometido a cirugía con enucleación de la lesión remanente más curetaje mecánico perilesional y uso de solución de Carnoy no modificada, preservando la cortical ósea vestibular mandibular tratada con solución de Carnoy no modificada y reposicionando este segmento óseo mediante osteosíntesis. Se realizó seguimiento clínico e imagenológico postoperatorio de 1 año verificando la remisión del quiste y la neoformación ósea en la zona intervenida. El uso de esta alternativa terapéutica permite evitar el colapso de los tejidos blandos en el defecto óseo subyacente y aportar tejido óseo autógeno tratado que permite una funcionalidad de tramado óseo al cual pueden migrar los elementos celulares para aportar en la regeneración tisular local.

The keratocyst is an odontogenic cyst in which different conservative and aggressive therapeutic options are described, with different success rates and recurrences. Depending on the treatment, the most aggressive techniques present better results but involve a more significant bone defect in the treated area compared to conservative techniques. The purpose of this case report is to document a surgical technique used in a 17-year-old male patient who underwent surgery after eight months of decompressive treatment with enucleation of the remaining lesion plus perilesional mechanical curettage and use of Carnoy's solution unmodified, preserving the mandibular vestibular bone cortex treated with unmodified Carnoy's solution and repositioning this bone segment by osteosynthesis. A one-year postoperative clinical and imaging follow-up was carried out, verifying the remission of the cyst and the new bone formation in the operated area. This therapeutic alternative makes possible to avoid the collapse of the soft tissues in the underlying bone defect and provide treated autogenous bone tissue that allows a bone mesh functionality to which the cellular elements can migrate to contribute to local tissue regeneration.

Reconstruction Plate Fracture: Mechanism and Recent Advances

Reconstruction plates with or without bone grafts are used to restore mandibular continuity, form and function following segmental resection of mandible. Fracture of reconstruction plate is observed in 2.9 % to 10% of cases reported in the literature excluding other complications. In this case, we report the fracture of stainless steel reconstruction plate used without bone graft and its management using locking reconstruction plate with non vascularised iliac crest graft following removal of the fractured plate. Review of literature describing incidence, pattern and causes of reconstruction plate fracture and its management is discussed.

Application of Deep Learning in Differential Diagnosis of Ameloblastoma and Odontogenic Keratocyst Based on Panoramic Radiographs / 中国医学科学院学报

Objective To evaluate the accuracy of different convolutional neural networks (CNN),representative deep learning models,in the differential diagnosis of ameloblastoma and odontogenic keratocyst,and subsequently compare the diagnosis results between models and oral radiologists. Methods A total of 1000 digital panoramic radiographs were retrospectively collected from the patients with ameloblastoma (500 radiographs) or odontogenic keratocyst (500 radiographs) in the Department of Oral and Maxillofacial Radiology,Peking University School of Stomatology.Eight CNN including ResNet (18,50,101),VGG (16,19),and EfficientNet (b1,b3,b5) were selected to distinguish ameloblastoma from odontogenic keratocyst.Transfer learning was employed to train 800 panoramic radiographs in the training set through 5-fold cross validation,and 200 panoramic radiographs in the test set were used for differential diagnosis.Chi square test was performed for comparing the performance among different CNN.Furthermore,7 oral radiologists (including 2 seniors and 5 juniors) made a diagnosis on the 200 panoramic radiographs in the test set,and the diagnosis results were compared between CNN and oral radiologists. Results The eight neural network models showed the diagnostic accuracy ranging from 82.50% to 87.50%,of which EfficientNet b1 had the highest accuracy of 87.50%.There was no significant difference in the diagnostic accuracy among the CNN models (P=0.998,P=0.905).The average diagnostic accuracy of oral radiologists was (70.30±5.48)%,and there was no statistical difference in the accuracy between senior and junior oral radiologists (P=0.883).The diagnostic accuracy of CNN models was higher than that of oral radiologists (P<0.001). Conclusion Deep learning CNN can realize accurate differential diagnosis between ameloblastoma and odontogenic keratocyst with panoramic radiographs,with higher diagnostic accuracy than oral radiologists.

Rol de la cirugía endoscópica en el tratamiento de quistes odontogénicos del hueso maxilar: revisión de la literatura

Los quistes odontogénicos son lesiones óseas, de carácter benigno, la mayoría asintomáticas, que habitualmente corresponden a un hallazgo radiológico. El tratamiento es quirúrgico y está condicionado por factores como localización, tamaño y la afectación de estructuras vecinas. El objetivo es elegir la modalidad de tratamiento que conlleve el menor riesgo de recurrencia, la mínima morbilidad, y al mismo tiempo la erradicación de la lesión. Siguiendo esta premisa han sido abordados, tradicionalmente, con técnicas abiertas con buenos resultados, pero con el advenimiento y desarrollo de la cirugía endoscópica, se empezó a usar esta técnica en forma exclusiva o en forma mixta para la resección de los quistes odontogénicos, logrando similares tasas de éxito, pero con menores complicaciones y morbilidad posoperatoria. Además, presenta una ventaja respecto del seguimiento para las recurrencias, ya que se pueden controlar endoscópicamente en la consulta ambulatoria. El objetivo de esta revisión es describir el desarrollo del rol de las cirugías endoscópicas para el tratamiento de lesiones odontogénicas maxilares.

Odontogenic cysts are benign bone lesions, most of them asymptomatic, which usually constitute a radiological finding. The treatment is surgical and is conditioned by factors such as location, size and involvement of nearby structures. The objective is to choose the treatment mode that presents the lowest risk of recurrence, the minimum morbidity, and at the same time, the eradication of the lesion. Following this premise, the treatment of these lesions has traditionally been approached with open techniques with good results but, with the advent and development of endoscopic surgery, this technique began to be used exclusively or in a mixed form for the resection of odontogenic cysts, achieving similar rates of surgical success, but with fewer complications and postoperative morbidity. It also has an advantage regarding follow-up for recurrences, since patients can be controlled endoscopically in the outpatient clinic. The objective of this review is to describe the development and role of endoscopic surgery for the treatment of maxillary odontogenic lesions.

Immunohistochemical Evaluation of Calretinin in Ameloblastoma, Odontogenic keratocyst and Dentigerous Cyst

Background: Calretinin plays an important role in calcium signalling and naturally expressed in nervous tissues. Various stud- ies suggest that calretinin may involve in amelogenesis. Calretinin also seems to have role in tumorigenesis since it regulates apoptosis. Aim: To find out whether there is any variation in expression of calretinin in Ameloblastoma, Odontogenic keratocyst and Dentigerous cyst. Materials & Methods: A total of 50 samples each from Ameloblastoma, odontogenic keratocyst and Dentigerous cyst were retrospectively studied. The immunohistochemical expression of calretinin was assessed by using calretinin antibody. Results: Chi square test was used to compare categorical parameters between groups. Kruskal Wallis Test and Mann-Whitney U Test were carried out to compare quantitative parameters among the groups. Statistically, significant values were obtained when comparing the immunohistochemical expression of calretinin in various odontogenic lesions studied and it was highest in ameloblastoma followed by OKC. None of the cases of dentigerous cyst were immunopositive for calretinin. Conclusion: There was statistically significant variation in the expression of calretinin among ameloblastoma, OKC and dentig- erous cyst and it contributes to the aggressiveness of those lesions.

Odontogenic tumors: A histopathological overview

Introduction: Odontogenic tumors (OTs) are rare and account for around 1% of jaw lesions including tumor and tumor-like lesions. OTs are a diverse category of lesions, displaying different inductive interactions. Although some are hamartomas, others are benign and malignant neoplasms with varying degrees of aggressiveness. Materials and Methods: We plan to review the histopathological aspects of OTs because of their diverse properties. At a tertiary medical and dental institute in Pune, India, we studied 28 cases of OTs over 2 years, from 2013 to 2015. Results: The most common forms of OTs were ameloblastoma (42.86%) and odontogenic keratocyst (21.15%). The highest number of OTs was found in the 21–30-year-old age group, with an even gender distribution. Conclusion: Ameloblastoma is the most common OT, accounting for roughly one-quarter of all jaw tumors. The majority of OTs occurs in young people aged 20–40 years. Fortunately, malignant OTs are extremely rare.

Comparison of CD105 (Endoglin) Expression in Odontogenic Keratocyst and Dentigerous Cyst - An Immunohistochemistry Study

Introduction: Tumors like Odontogenic Keratocyst (OKC), Dentigerous Cyst (DC)and Pyogenic Granuloma are frequently oc- curring in the oral cavity with each of them having relation to angiogenesis. Higher angiogenesis may be associated with increased tissue metabolism, more aggressive biologic behaviour, and increased recurrence and growth rate. Tumor growth is dependent not only on a rise in the number of blood vessels, but also on factors such as protein molecules produced in en- dothelial cells. Microvessel density (MVD), Microvessel area (MVA), Microvessel perimeter (MVP) can predict the growth of the tumour, metastasis and patient’s survival and this value is related to the aggressiveness of the tumour. Aims: The aim of the present study was to determine the angiogenic potential of OKC and DCcompared with normal mucosa using CD 105 marker immunohistochemically. Materials and methods: Immunohistochemical staining was done on 70 paraffin embedded tissue samples. Histopathologi- cally diagnosed cases of OKC, DC and Pyogenic granuloma and healthy gingival tissue samples were retrieved for the study purpose. Results: There was no statistically significant difference in the mean MVD, MVA, MVP values of OKC, DC and pyogenic granu- loma groups. Conclusion: The angiogenic potential was determined in 3 different cases of OKC, Dentigerous Cyst and Pyogenic granuloma in terms of MVD, MVA and MVP and compared to normal mucosa using CD105 marker immunohistochemically.Though the mean values of MVA, MVD, MVP were statistically not significant but was estimated to be higher than the normal mucosa

Diagnóstico y tratamiento conservador del queratoquiste odontogénico

Resumen El queratoquiste odontogénico es una entidad potencialmente agresiva y de alta recurrencia, con características clínicas y radiográficas no definidas claramente. Se presenta en cualquier etapa de la vida. El 70 a 80% se ubican en la mandíbula, comúnmente en la región de tercer molar y ángulo mandibular desde donde progresan hacia la rama y cuerpo. Son lesiones en general asintomáticas que pueden alcanzar dimensiones notables. A menudo se encuentran en el examen radiográfico de rutina. El objetivo del presente artículo es reportar el caso de una mujer de 40 años de edad, con un queratoquiste odontogénico paraqueratinizado, evaluando sus características clínicas, radiográficas e histopatológicas que llevaron a un manejo y tratamiento conservador oportuno y adecuado con resultados satisfactorios. Concluyendo que la minuciosa elaboración de la historia clínica basado en hallazgos clínicos, radiográficos e histopatológicos conduce a un diagnóstico correcto, que permite la elaboración de un plan de tratamiento adecuado.

Resumo O Queratocisto odontogênico potencialmente agressivo e de alta recorrência, com características clínicas e radiográficas não claramente definidas. Ocorre em qualquer estágio da vida. 70 a 80% estão localizados na mandíbula, geralmente na região do terceiro molar e no ângulo mandibular de onde progridem para o ramo e o corpo. São lesões geralmente assintomáticas que podem atingir dimensões notáveis. Eles são freqüentemente encontrados no exame radiográfico de rotina. O objetivo deste artigo é relatar o caso de uma mulher de 40 anos com um queratocisto odontogênico paraqueratinizado, avaliando suas características clínicas, radiográficas e histopatológicas que conducem ao manejo e tratamento conservador oportuno e adequado, com resultados satisfatórios. Concluindo que o cuidadoso preparo da história médica com base em achados clínicos, radiográficos e histopatológicos leva a um diagnóstico correto, o que permite o desenvolvimento de um plano de tratamento adequado.

Abstract Odontogenic keratocysts are potentially aggressive and have high recurrence rates. Their clinical and radiographic features are not clearly defined. They can occur at any stage of life. Seventy to 80% are located in the mandible, commonly in the area between the third molar and the mandibular angle, from where they grow towards the ramus and body. They are generally asymptomatic lesions that can grow considerably. They are often found on routine radiographs. This paper reports the case of a 40-year-old woman with a parakeratinized odontogenic keratocyst. After assessing the cyst's clinical, radiographic and histopathological features, we managed and treated the condition timely, conservatively, and with satisfactory results. We concluded that preparing the patient's dental history carefully and based on clinical, radiographic, and histopathological findings allowed us to make the correct diagnosis and develop the necessary treatment plan.

Is enucleation followed by peripheral ostectomy and Carnoy's solution application an adequate treatment for Odontogenic keratocyst? A case series with up to five years of follow up / A enucleação seguida da osteotomia periférica e a aplicação de solução de Carnoy é um tratamento adequado para o ceratocisto odontogênico? Uma série de casos com acompanhamento de até cinco anos

Objective: To evaluate the treatment outcome of enucleation and peripheral ostectomy with the use of Carnoy's solution for management of Odontogenic keratocyst. Material and Methods: 17 patients with OKC who reported from 2011 to 2015 were included. All the cases were treated by enucleation and peripheral ostectomy of 0.5mm followed by Carnoy's solution cauterization for 4 minutes. All patients were followed up for 4-5 years. Results: All the cases were followed-up by using serial panoramic radiography and clinical evaluation at regular intervals. No recurrence was reported in any of the cases. Conclusion: Treatment of Odontogenic keratocyst by enucleation and 0.5mm of peripheral ostectomy, followed by Carnoy's solution cauterization for 4 minutes is an effective treatment with zero recurrence rates for five years of follow-up (AU)

Objetivo: Avaliar o resultado do tratamento de enucleação e osteotomia periférica com o uso de solução de Carnoy para o manejo do ceratocisto odontogênico (OKC). Material e Métodos: 17 pacientes com OKC com acompanhamento de 2011 a 2015 foram incluídos. Todos os casos foram tratados através da enucleação e osteotomia periférica de 0,5 mm, seguido da cauterização com solução de Carnoy por 4 minutos. Todos os pacientes foram acompanhados por 4-5 anos. Resultados: Todos os casos foram acompanhados por meio de séries de radiografias panorâmicas e avaliação clínica em intervalos regulares. Nenhuma recorrência foi reportada em nenhum dos casos. Conclusão: O tratamento de ceratocisto odontogênico por meio da enucleação e osteotomia periférica de 0,5mm, seguido da cauterização com solução de Carnoy por 4 minutos é um tratamento efetivo com zero taxa de recorrência em um acompanhamento de 5 anos. (AU)

Manejo Quirúrgico del Queratoquiste Odontogénico con Invasión al Seno Maxilar: Reporte de Serie Casos y Revisión de la Literatura

RESUMEN: El queratoquiste odontogénico (QQO) es una quiste intraóseo poco frecuente que varía entre un 3 a 11% de todos los quistes odontogénicos, su ubicación en el maxilar es rara y la invasión al seno maxilar lo es aún más. El QQO es una patología benigna, localmente agresiva que tiene una alta tasa de recidiva. Se han descrito diversas técnicas quirúrgicas para su tratamiento, las cuales van desde lo más conservador como la enucleación a lo más radical como una resección. El uso de agentes coadyuvantes químicos o cauterizantes han logrado disminuir la tasa de recidiva en conjunto con tratamientos más conservadores, disminuyendo la morbilidad y secuelas asociada a una resección. El objetivo de este trabajo es presentar una serie de casos clínicos de QQO que invaden el seno maxilar, su tratamiento de manera conservadora y una revisión de la literatura comparando los diversos tratamientos y su tasa de recidiva.

ABSTRACT: Odontogenic keratocyst (OC) is a rare intraosseous pathology that varies between 3 % and 11 % of all odontogenic cysts, its location in the maxilla is rare, and invasion of the maxillary sinus is even more so. OC is a benign, locally aggressive pathology that has a high recurrence rate. Various surgical techniques have been described for its treatment, ranging from the most conservative, such as enucleation, to the most radical, such as resection. The use of chemical or cauterizing adjuvant agents has managed to reduce the recurrence rate in conjunction with more conservative treatments, reducing the morbidity and sequelae associated with a resection. The objective of this work is to present a series of clinical cases of OC that invade the maxillary sinus, their treatment being carried out in a conservatively manner, and a review of the literature comparing the various treatments and their recurrence rate.

Queratoquistes odontogénicos maxilares en paciente con síndrome de Gorlin. Descripción de un caso y revisión de la literatura / Maxillary odontogenic keratocysts in a Gorlin síndrome patient: Case report and literatura review

Los queratoquistes maxilares son frecuentes en pacientes con síndrome de Gorlin. Su tratamiento es debatido por su alta tendencia a la recidiva. En los últimos años la cirugía endoscópica nasosinusal ha adquirido importancia en el manejo de esta patología. Exponemos en caso de un varón de 16 años afecto de este síndrome con queratoquistes maxilares donde se realiza un abordaje combinado, endonasal y transoral.

Maxillary keratocysts are frequent in Gorlin Syndrome patients. Its treatment is discussed due to the high tendency to recurrence. In the last years the sinonasal endoscopic surgery has become an important tool in the management of this pathology. We report a 16 years old boy with Gorlin Syndrome and maxillary keratocysts treated with a trans-nasal endoscopic and intra-oral combined approach.

Queratoquiste odontogénico: características diagnósticas y tratamiento quirúrgico conservador / Odontogenic keratocyst: diagnostic characteristics and coservative surgical treatment

El queratoquiste es una lesión odontogénica benigna de comportamiento agresivo, que deriva probablemente de la lámina dental. Se localiza frecuentemente en la parte posterior del hueso mandibular en la zona del tercer molar, ángulo mandibular y puede progresar hacia la rama y el cuerpo, presentando una asociación directa con órganos dentales retenidos. Existe una amplia variedad de técnicas para el tratamiento de esta lesión, como pueden ser descompresión, marsupialización, enucleación y la resección en bloque, así como también la combinación de estas con métodos coadyuvantes. El interés en esta lesión radica por su elevado índice de recidiva que se estima en un 20-30% en la población en general, sin embargo, en la actualidad se ha optado por el uso de tratamientos conservadores como la marsupialización y la descompresión que han demostrado una mayor efectividad y menor recidiva. Es por esto que tras el tratamiento de las lesiones es importante dar un seguimiento a largo plazo. El objetivo de la publicación es presentar el reporte de un caso clínico de un paciente masculino de 21 años con un diagnóstico de queratoquiste odontogénico tratado con una técnica de descompresión durante cinco meses para su posterior enucleación quirúrgica.Se ha comprobado que el tratamiento de descompresión seguido de enucleación y acompañado de métodos coadyuvantes resulta un manejo terapéutico adecuado para los queratoquistes por demostrar su menor tasa de recidiva y su comportamiento noble con estructuras vitales vecinas. Sin embargo, en todos los casos se debe realizar un seguimiento periódico para prevenir la recurrencia de la lesión.

Introduction: Keratocyst is a benign odontogenic lesion with aggressive behavior, probably derived from the dental lamina. It is frequently located in the posterior part of the mandibular bone in the area of the third molar, mandibular angle and can progress towards the ramus and the body, presenting a direct association with retained dental organs. There is a wide variety of techniques for the treatment of this lesion, such as decompression, marsupialization, enucleation, and en bloc resection, as well as the combination of these with adjuvant methods. The interest in this lesion stems from its high recurrence rate, which is estimated to be 20-30% in the general population, however, at present the use of conservative treatments such as marsupialization and decompression has been chosen. demonstrated greater effectiveness and less recurrence. This is why after treating the lesions it is important to give a long-term follow-up.The objective of the publication is to present the report of a clinical case of a 21-year-old male patient with a diagnosis of odontogenic keratocyst treated with a decompression technique for five months for subsequent surgical enucleation.Conclusion: It has been proven that decompression treatment followed by enucleation and accompanied by adjuvant methods is an adequate therapeutic management for keratocysts as it demonstrates its lower rate of recurrence and its noble behavior with neighboring vital structures. However, in all cases, regular monitoring should be carried out to prevent recurrence of the lesion

Odontogenic Keratocyst: Eight-Year Follow-Up After Conservative Treatment

ABSTRACT: This study aimed to describe the conservative surgical management of odontogenic keratocyst, comparing with clinical and demographic findings in the literature, based on a literature review, using the quality criteria established in the literature for clinical cases and case series. We searched for cases of keratocysts published in four databases. We selected cases of patients followed up at least one year after sugical treatment. We described the case of a patient who was asymptomatic, and the lesion was detected by routine radiographic examination. At the same surgical time, we enucleated the lesion, followed by curettage and drain installation. Currently, there are no signs of disease recurrence. We followed the CARE guidelines (Case Report Guidelines), in this report. Literature review disclosed 27 cases. Keratocyst was frequent in male-adult patients, and the mean follow-up time after surgery was 46.7 ± 28.1 months. The main clinical findings such as association with teeth, location, extension of lesion, and radiographic pattern corroborate the classic pattern of described cases reported by literature with a low general rate of recurrences. In conclusion, conservative treatment was successful for the clinical case described, over an eight-year follow-up. Most of the described studies did not show lesion recurrence after using the conservative surgical treatment. However, we draw attention to the importance of the long follow up period of our case.

RESUMEN: El objetivo de este estudio fue describir el tratamiento quirúrgico conservador del queratoquiste odontogénico, obedeciendo las pautas de CARE (Case Report Guidelines). Los hallazgos clínicos y demográficos en la literatura se compararon basándose en una revisión desarrollada a través de los Criterios de calidad establecidos en la literatura para casos clínicos y series de casos, donde se consultaron cuatro bases de datos para la investigación en salud. La lesión encontrada en el paciente del presente estudio fue detectada en un examen radiográfico de rutina, sin manifestaciones clínicas siendo tratada quirúrgicamente con abordaje conservador. El tratamiento con enucleación, curetaje e instalación de drenaje se instituyó al mismo tiempo quirúrgico y, actualmente, no muestra signos de recurrencia de la enfermedad. De los 27 casos utilizados en la revisión, la lesión predominó en pacientes hombres adultos,con un seguimiento medio de 46,7 ± 28,1 después de la cirugía. Los principales hallazgos clínicos como asociación con dientes, localización, patrón radiográfico y lesión extensa, corroboran el patrón clásico de presentación de la enfermedad descrito en el caso reportado. En conclusión, el tratamiento conservador fue exitoso para el caso clínico descrito, durante un seguimiento de ocho años. La mayoría de los estudios revisados no mostraron recurrencias con el tratamiento quirúrgico conservador empleado, sin embargo, se aconseja realizar un seguimiento a largo plazo.

Odontogenic Keratocyst of the Posterior Maxilla: Report of an Unusual Case

ABSTRACT The odontogenic keratocyst is a developmental odontogenic cyst. It can occur anywhere in the jaws, but it is commonly seen in the posterior part of the mandible. Lesions have a propensity to grow along the internal aspect of the jaws, and clinically observable expansion of bone occurs late. These lesions have a different mechanism of growth as compared with other cysts, and may show varying radiographic appearances. This paper reports a distinctive case of an odontogenic keratocyst in a 33-year-old female patient. The cyst has an unusual radiographic presentation of two unilocular radiolucencies overlapping each other in the left maxillary premolar-molar region. The study also presents a literature review.

Peripheral odontogenic keratocysts in buccal soft tissues: two cases report / 华西口腔医学杂志

Peripheral odontogenic keratocysts are rarely observed, and cases of odontogenic keratocysts of buccal soft tissues are even rarer. This study was performed to present two rare cases of odontogenic keratocysts in buccal soft tissues and review related literature.

Basal cell nevus syndrome with Duchenne muscular dystrophy: a case report / 华西口腔医学杂志

Basal cell nevus syndrome (BCNS), also known as Gorlin-Goltz syndrome, is a rare autosomal dominant genetic disease. It is thought to be caused by a mutation in the PTCH1 gene, and its incidence is 1/57 000 to 1/256 000. The case of a 7-year-old patient with BCNS and Duchenne muscular dystrophy was reported in this paper.

Enucleación secundaria a descompresión o marsupialización para pacientes con queratoquiste / Secondary enucleation to decompression/marsupialization for keratocystic odontogenic tumors

RESUMEN: Introducción: El queratoquiste o tumor odontogénico queratoquístico es una de las neoplasias odontogénicas "benignas" más frecuentes. Existen múltiples opciones de tratamiento, pero no existe consenso sobre ellas. Este resumen busca evaluar la efectividad de la enucleación secundaria a descompresión o marsupialización. Métodos: Realizamos una búsqueda en Epistemonikos, la mayor base de datos de revisiones sistemáticas en salud, la cual es mantenida mediante el cribado de múltiples fuentes de información, incluyendo MEDLINE, EMBASE, Cochrane, entre otras. Extrajimos los datos desde las revisiones identificadas, analizamos los datos de los estudios primarios, realizamos un metaanálisis y preparamos una tabla de resumen de los resultados utilizando el método GRADE. Resultados y conclusiones: Identificamos cuatro revisiones sistemáticas que en conjunto incluyeron cinco estudios primarios, los cuales corresponden a estudios observacionales. Concluimos que no es posible establecer con claridad si la enucleación secundaria a descompresión o marsupialización disminuye la recidiva de queratoquiste. Otros desenlaces como dolor postoperatorio, infección y fractura patológica no fueron reportados.

ABSTRACT: Introduction: Keratocystic odontogenic tumor is one of the most common odontogenic neoplasms. Many treatment modalities have been recommended for the treatment of keratocystic , but there is no consensus regarding the optimal treatment. This summary seeks to evaluate the effectiveness of enucleation secondary to decompression or marsupialization. Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. Results and conclusions: We identified 4 systematic reviews including 5 studies overall, all corresponding to observational studies. There is uncertainty whether secondary enucleation to decompression/marsupialization reduces recurrence rate as the certainty of the evidence has been assessed as very low. No studies were found that looked at postoperative pain, infection and pathologic fracture.

Inflamación mixta severa con pérdida del techo del canal mandibular: una variación de las infecciones odontogénicas asociada a pericoronaritis / Severe mixed inflammation with loss of the mandibular canal roof: a variation in odontogenic infections associated with pericoronaritis

Las infecciones cuando pasan a ser crónicas y recurrentes como puede ser el caso de una pericoronaritis medicada, mas no tratada una y otra vez, traen como consecuencia resistencia y proliferación bacteriana. Se da el caso de formaciones de tejidos patológicos e imágenes radiográficas que orientan a posibles diagnósticos, que hasta no ser tratadas por medio de diferentes técnicas como la marsupialización o enucleación, con el complemento de la biopsia insicional o exicional que determina el tipo de patología presente. Esto lleva al objetivo general: determinar el tipo de lesión patológica presente en el ángulo y cuerpo mandibular asociado a la ud: 48 Objetivos específicos: Identificar la lesión patológica presente en Angulo y parte del cuerpo mandibular asociada a la ud: 48. Muestra: paciente de 30 años de edad, masculino, caso clínico de una inflamación mixta severa, la clínica y sus hallazgos radiográficos, se sospechaba de un posible queratoquiste, quiste dentígeros o quiste odontogénico ortoqueratinizado, extracción dental ud: 48, retiro y legrado del tejido circundante, toma de biopsia exicional, exámenes de laboratorio, ortopantomografia, tomografía, fotografías clínicas. Metodología: paradigma positivista, enfoque cuantitativo, diseño no experimental. Modalidad de campo, tipo estudio de caso. La entrevista, el instrumento guión de las preguntas para la historia clínica fueron la técnica y el instrumento. Resultados: inflamación mixta severa, lo cual procede de una infección asociada a pericoronaritis recurrente, esto mediante resultado histopatológico. Conclusiones: el estudio histopatológico es quien determina el diagnóstico final a pesar que la clínica induzca a posibles diagnósticos diferenciales(AU)

When infections become chronic and recurrent, such as a medicated pericoronitis, but not treated repeatedly, they result in resistance and bacterial proliferation. There is the case of pathological tissue formations and radiographic images that guide possible diagnoses, which until they are not treated by means of different techniques such as marsupialization or enucleation, with the complement of the incitional or exicional biopsy that determines the type of pathology present. This leads to the general objective: to determine the type of pathological lesion present in the mandibular angle and body associated with ud: 48. Specific objectives: Identify the pathological lesion present in Angle and part of the mandibular body associated with ud: 48. Sample: 30-year-old male patient, clinical case of severe mixed inflammation, clinical symptoms and radiographic findings, suspected of a possible keratocyst, dentigerous cyst or orthokeratinized odontogenic cyst, tooth extraction ud: 48, removal and curettage of the surrounding tissue, exicional biopsy, laboratory tests, orthopantomography, tomography, clinical photographs. Methodology: positivist paradigm, quantitative approach, non-experimental design. Field modality, case study type. The interview, the instrument script the questions for the clinical history were the technique and the instrument. Results: severe mixed inflammation, which comes from an infection associated with recurrent pericoronitis, this through histopathological result. Conclusions: the histopathological study is the one who determines the final diagnosis, despite the fact that the symptoms lead to possible differential diagnoses(AU)