Vulvar Vestibular Papillomatosis / 대한피부과학회지

Vulvar vestibular papillomatosis (VVP) is a benign condition that can be viewed as the female equivalent of male pearly penile papules. Clinically, VVP is quite often misdiagnosed as condyloma acuminatum. As opposed to condyloma, VVP lesions arise from a distinct mucosal base, match the color of the surrounding mucosa, show symmetrical distribution, and are limited to the inner aspect of the labia minora. Although VVP is quite well known in the gynecological field, this disease entity is not commonly recognized in dermatology settings. Furthermore, a literature search for VVP revealed only nine reports in dermatological journals including one report from Korea. Therefore, through our report we wish to create awareness among dermatologists regarding the occurrence of this frequent but often ignored entity. Recognizing and understanding that papillomatosis of the vulvar vestibule is a normal variant will help dermatologists to avoid incorrect diagnosis and repeated unnecessary treatment.

The Association of Relative Risk of High Risk HPV with Cervical Abnormalities in Bahrain.

Background: Th e study was conducted to see the association of cervical abnormalities in relation to high risk Human Papilloma Virus (HR-HPV) infection at King Hamad University Hospital, Bahrain. Materials and Methods: It was a retrospective cohort study completed in 3 years at King Hamad University Hospital, Department Pathology Lab and other private Hospitals of Bahrain. Patients of Obstetrics and Gynecology out patient’s clinic and other requesting private hospitals were included in this study.A non-probability purposive sampling technique was used for this retrospective review of 160pathology reports and HPV cervista reports. Data was collected from I-Seha and patients Al-care, and was transferred and assessed SPSS-version 22. Results: Th ere were 160 cases in total, who were examined for HPV–HR DNA using Cervista molecular testing. Th ere were 73 cases were Positive for HPV and 87 cases negative for HPV. Th e minimum age of patiesnt's was 20 years while the max was 70 years. Th e mean age was 42.5 years. HR-HPV was detected in (100%) all cervical HSIL cases and in 71% of LSIL cases. Cervical intraepithelial lesion CIN2/3+ was signifi cantly associated with HR-HPV positive cases. Compared to HPV positive cases, here was no cervical intraepithelial lesion (CIN) of any grade found in HR_HPV negative cases. Th ere were only four cases with LSIL found to be R-HPV positive, which may be associated with Low-risk HPV infection. Conclusion: Th ere was strongest association of cervical neoplastic lesions with high risk HPV to control.

Diagnostic Algorithm to Reflect Regressive Changes of Human Papilloma Virus in Tissue Biopsies

PURPOSE: Landmark indicators have not yet to be developed to detect the regression of cervical intraepithelial neoplasia (CIN). We propose that quantitative viral load and indicative histological criteria can be used to differentiate between atypical squamous cells of undetermined significance (ASCUS) and a CIN of grade 1. MATERIALS AND METHODS: We collected 115 tissue biopsies from women who tested positive for the human papilloma virus (HPV). Nine morphological parameters including nuclear size, perinuclear halo, hyperchromasia, typical koilocyte (TK), abortive koilocyte (AK), bi-/multi-nucleation, keratohyaline granules, inflammation, and dyskeratosis were examined for each case. Correlation analyses, cumulative logistic regression, and binary logistic regression were used to determine optimal cut-off values of HPV copy numbers. The parameters TK, perinuclear halo, multi-nucleation, and nuclear size were significantly correlated quantitatively to HPV copy number. RESULTS: An HPV loading number of 58.9 and AK number of 20 were optimal to discriminate between negative and subtle findings in biopsies. An HPV loading number of 271.49 and AK of 20 were optimal for discriminating between equivocal changes and obvious koilocytosis. CONCLUSION: We propose that a squamous epithelial lesion with AK of >20 and quantitative HPV copy number between 58.9-271.49 represents a new spectrum of subtle pathological findings, characterized by AK in ASCUS. This can be described as a distinct entity and called "regressing koilocytosis".

Detection of Human Papillomavirus in Recurrent Conjunctival Papilloma

The human papillomavirus(HPV) has been implicated in the pathogenesis of human conjunctival papilloma, becauses it has clinically viral nature and pathologically koilocytosis, typically found in other papilloma-induced tumors. To evaluate the association of HPV with conjunctival papilloma, 3 recurrent conjunctival papiloma were removed through cryo-excision and examined for the presence of human papillomavirus by polymerase chain reaction. All 3 cases were positive reactions to papillomavirus serotype 6/11, but koilocytosis was present in 2 cases.

Atypical Condyloma of Uterine Cervix: It's Cytological Similarity to Squamous Cell Carcinoma

Atypical condyloma is a variant of flat condyloma characterized by the presence of atypical koilocytes having large hyperchromatic, smudged and often bizarre nuclei. Atypical condyloma can be frequently misdiagnosed on cytologic smear and on tissue sections by its marked cellular atypia, as high grade dysplasia, in situ or even invasive squamous cell carcinoma. We described two cases of atypical condyloma of the female genital tract. The cytologic features and histologic changes were reminiscent of those of invasive squamous cell carcinoma and severe degree of dysplasia of the uterine cervix. The differential findings between atypical condyloma and squamous cell carcinoma were discussed in detail.