ABSTRACT
Siddhars said about various diseases and the treatment methods with herbs, minerals and animal products. In Siddha literatures viral fevers can be compared to Vatha Kapha Suram and therefore decoction for this Suram is taken from classical Siddha text book and the ingredients are searched for pharmacological activity and toxicity study from 118 published journal papers from Pubmed, Scopus, Google Scholar, Research Gate and Science Direct. Collected data is entered in MS excel and analysed using RFC score. All together there are 51 pharmacological activities are published for these nine ingredients. In which Anti-inflammatory has RFC=1, other properties like antipyretic, anti-tussive, bronchodialator, anti-asthmatic, analgesic, neuro-regenerative, neuroprotective, anti-diarrhoeal, anti-emetic, neuroprotective, analgesic, sedative has more than 0.55 RFC score. More than this cardioprotective, renoprotective, hepatoprotective, and other protective properties are present in more than 50% of ingredients. In toxicity studies no toxic effects are seen in in vivo studies for the ingredients The Suvai, Thanmai, Pirivu, in Siddha aspect, of these ingredients can highly reduces Vatha and Kapha disorders. Therefore, the decoction shows significant pharmacological activity for the sign and symptoms of viral infections.
ABSTRACT
BackgroundCurrently, no vaccines or modern drugs are available for dengue and chikungunya and only symptomatic relief is provided to the patients. Siddha medicine, a traditional form of indigenous medical system uses specific polyherbal formulations for the treatment of such infections with considerable success. One such polyherbal formulation for the treatment of chikungunya and dengue is Nilavembu kudineer (NVK). The mechanistic details of this drug as an antiviral for chikungunya virus (CHIKV) and dengue virus (DENV) is poorly understood.ObjectivesThe current study was undertaken to study the efficacy of NVK as an antiviral formulation against CHIKV and DENV.Materials and methodsCytotoxicity assays (MTT) were performed to determine the role of NVK as an antiviral during chikungunya and dengue infections in the following conditions-i). post infection, ii). during active infections and iii) protective, not allowing virus infection.ResultsIt was observed that NVK provides protection against CHIKV and DENV-2 during active infection as well can help to prevent virus infection in the cells and it mainly depends on the cellular availability of drugs for maximum protection against both the infections.ConclusionOur study establishes that extraction protocols are important to ensure maximum efficacy of NVK along with the time of addition of the drug during CHIKV and DENV infections in the cells. This study provides insights to the possible mode of action of NVK in in vitro condition during CHIKV and DENV infection.
ABSTRACT
Autism is most common mental disabilities in childhood with unknown aetiology nowadays. In our Siddha paediatric text, the symptoms of Mantha sanni are nearly correlated with Autism Spectrum Disorder (ASD). Objectives: The Main objectives of the study is to evaluate the Siddha therapeutic management and to analyse the clinical assessment of Mantha sanni (Autism Spectrum Disorder) with Experimental formulations and procedures and the secondary objectives are to calibrate the resemblance and the equivalence of Mantha Sanni with Autism Spectrum Disorder and to explore the Siddha therapeutic management in Autism children. Methods: In preclinical studies of Physicochemical, Phytochemical activities and Pharmacological activities were done. In clinical studies, among 30 children were included in inclusion criteria and received Kuruver kudineer as internal twice a day and Sambrani thuvalai and Mysatchi pugai as external once in a day. The Experimental period was 90 days and the activities of ASD children were recorded 0th day followed by every 30th day. Results and Discussion: In this clinical study indicating that both internal and external medicine had superior action as far as improvement in ASD is considered. Since Kuruver Kudineer use is to enhance cognitive skills, enhance nerve impulse transmission, research has been focused on the mechanism behind this activity. Thuvalai with Sambrani ennai use to enhance the Sitting tolerance, invigorating feeling and can give comfort. Fumigation with Mysatchi pugai is one of the methods of treatment in ancient period. It has to enhancing the mind calming activity, reduced hyperactivity, induced sound sleep, reduced screaming and irritable cry. In Statistical analysis, there is significant difference between before and after treatment on clinical assessment parameter score i.e. 86% improvement in this score after treatment. Based on the results of this clinical study, it can be conclude that Kuruver kudineer as internal and Sambrani thuvalai and Mysatchi pugai as external. It has a definite action as well as clinical efficacy on symptoms in ASD children seen in regular OPD and IPD. The effects of Internal and external therapies may be due individual drugs multipronged action. Further study is required for scientific validation to prove its clinical efficacy in multicentre clinical study.