Chemical Constituents from Barks of Lannea coromandelica / 中草药·英文版

Objective: To study the chemical constituents from the barks of Lannea coromandelica. Methods: The chemical constituents were isolated and purified by column chromatography on silica gel column. NMR spectra were used for structural identification. Results: Thirteen compounds were isolated and identified as quercetin (1), (2. S,3. S,4. R,10. E)-2-[(2'. R)-2'-hydroxytetracosanoyl amino]-10-octadecene-1,3,4-triol (2), aralia cerebroside (3), 5,5'-dibuthoxy-2,2'-bifuran (4), β-sitosteryl-3β-glucopyranoside-6'-. O-palmitate (5), β-sitosterol palmitate (6), myricadiol (7), protocatechuic acid (8), p-hydroxybenzoic acidethyl ester (9), isovanillin (10), trans-cinnamic acid (11), palmitic acid (12), and stearic acid (13). Conclusion: Compounds 2-13 are isolated from this plant for the first time. © 2014 Tianjin Press of Chinese Herbal Medicines.

Protective effect of Lannea coromandelica Houtt. Merrill. against three common pathogens.

Background: Ayurvedic text reports suggested Lannea coromandelica is used in various microbial origin disorders like dysentery, sore eyes and leprosy, genital wounds. Objective: The present study was designed to investigate the antimicrobial effect of L. coromandelica Houtt. Merrill. (Anacardiaceae) on microbes which cause female reproductive tract infection. Materials and Methods: Ethanolic and aqueous bark extract (Ext.) of L. coromandelica were screened against strains of Streptococcus pyogens, Staphylococcus aureus, and Candida albicans. Antimicrobial assay had been done with agar well diffusion method. Results: Ethanolic extracts [100% (16 mg), 75% (12 mg) and 50% (8 mg)] of L. coromandelica exhibited zone of inhibition (ZI) 19.21 mm, 18.45 mm, 16.41 mm and 18.12 mm, 17.35 mm, 16.35 mm against S. aureus and S. pyogens, respectively. However, only 100% and 75% ethanolic extract showed (ZI-19.18 mm, 16.29 mm) activity against C. albicans. Nevertheless, aqueous extract (100%) showed higher antifungal activity (ZI-16.97 mm). Ciprofl oxacin and amphotericin B were used as a standard drugs in the present study. Conclusion: The results demonstrated that L. coromandelica Houtt. Merrill. have antibacterial activity against S. pyogens, S. aureus and antifungal property against C. albicans. Our fi ndings corroborate the ethnobotanical use of L. coromandelica in traditional medicine system (Ayurveda) of India.