A case report of large cell undifferentiated carcinoma of the urinary bladder / 中华泌尿外科杂志

The clinical pathological data of a patient large cell undifferentiated bladder carcinoma was retrospectively analyzed and understand.The clinical and imaging findings of large cell undifferentiated bladder carcinoma was nonspecific.Diagnosis depended on the pathological and immuno-histochemical staining.The tumor is aggressive with high risk of recurrence.It is mainly treated with radical resection.

Survival of patients with non-small cell lung cancer in King Abdulaziz University Hospital, Jeddah, Saudi

Background: The improvement in the survival rate from cancer is increased due to advancement in the early detection, combined modality therapy and right therapeutic strategies. This study was aimed to assess the survival outcomes of patients diagnosed with non-small cell lung cancer (NSCLC) at King Abdulaziz University Hospital (KAUH).Methods: This retrospective cohort study included all patients aged 14 years and older with a diagnosis of NSCLC from 2007 to 2017 using electronic medical records at KAUH. Data analysis was performed by using Stata SE, version 15.0. Survival was defined as the time the patient lived in months from the date of pathological diagnosis to the date of last follow-up or death. All variables in a univariate and multivariate analysis were included.Results: Adenocarcinoma was the most common type of NSCLC observed in both genders, accounting for 43.70% of all cases. Of the patients diagnosed with NSCLC the overall median survival was 12.2 months (interval=16.9). And among all variables, surgical treatment was associated with a 71% relative reduction in risk of death (hazard ratio 0.29, p<0.014), and chemotherapy a 57% relative reduction in risk of death (hazard ratio 0.43, p<0.013).Conclusions: The median age of diagnosis of NSCLC in Kingdom of Saudi Arabia (KSA) was younger than United States of America, this could be due to many factors including smoking. The number of lung cancer cases among women was lower than men.

Clinicopathologic features, treatment, prognosis and prognostic factors of neuroendocrine carcinoma of the endometrium: a retrospective analysis of 42 cases from the Kansai Clinical Oncology Group/Intergroup study in Japan / 부인종양

OBJECTIVE: We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically analyze the prognosis of this disease. METHODS: At medical institutions participating in the Kansai Clinical Oncology Group/Intergroup, cases diagnosed at a central pathologic review as neuroendocrine carcinoma of the endometrium between 1995 and 2014 were enrolled. We retrospectively analyzed the clinicopathologic features, treatment, prognosis and prognostic factors of this disease. RESULTS: A total of 65 cases were registered from 18 medical institutions in Japan. Of these, 42 (64.6%) cases were diagnosed as neuroendocrine carcinoma of the endometrium based on the central pathological review and thus included in the study. Advanced International Federation of Gynecology and Obstetrics stages (stage III and IV) and pure type small cell neuroendocrine carcinoma cases had a significantly worse prognosis. Upon multivariate analysis, only histologic subtypes and surgery were significant prognostic factors. Pure type cases had a significantly worse prognosis compared to mixed type cases and complete surgery cases had a significantly better prognosis compared to cases with no or incomplete surgery. CONCLUSION: Our findings suggest that complete surgery improves the prognosis of neuroendocrine carcinoma of the endometrium. Even among cases with advanced disease stages, if complete surgery is expected to be achieved, clinicians should consider curative surgery to improve the prognosis of neuroendocrine carcinoma of the endometrium.

A Case of Primary Mediastinal Choriocarcinoma Mimicking Large Cell Carcinoma of the Lung in a Male Patient in His 50s / 대한내과학회지

Primary mediastinal choriocarcinoma is an extremely rare extragonadal germ cell malignancy. A 58-year-old male presented with a lung mass, which was incidentally discovered during a periodic medical checkup. Percutaneous needle biopsy showed poorly differentiated carcinoma with large pleomorphic morphology. After the patient underwent right upper lobectomy and lymphadenectomy, the final diagnosis was choriocarcinoma. The patient received four sequential cycles of BEP chemotherapy (bleomycin, etoposide, cisplatin). After completion of BEP chemotherapy, follow-up positron emission tomography (PET) showed a complete metabolic response. Although the mediastinum is one of the most common primary sites of extragonadal germ cell tumors, primary mediastinal choriocarcinoma is liable to be misdiagnosed as lung cancer or Hodgkin lymphoma. Notably, large cell carcinoma of the lung can be confused with choriocarcinoma even after percutaneous needle biopsy. We report a case of primary mediastinal choriocarcinoma mimicking large cell carcinoma of the lung in a male patient in his 50s.

A Case of Large Cell Neuroendocrine Carcinoma of the Parotid Gland / 대한이비인후과학회지

Large cell neuroendocrine carcinoma is a rare malignant tumor of the parotid gland and has poor prognosis due to its aggressive and rapid growth and easy metastasis. Large cell neuroendocrine carcinoma usually occurs in the lung and intestine. However, a few cases of large cell neuroendocrine carcinoma have been reported in other sites such as the uterine cervix, thymus, urinary bladder, ovary and the ampulla of vater. In large cell neuroendocrine carcinoma of the parotid gland, radical parotidectomy is the first therapeutic step and can be followed by local radiation therapy. We report one case of primary large cell neuroendocrine carcinoma occurring in the parotid gland, and discuss the literature.

Two Cases of Neuroendocrine Carcinomas of the Stomach: Large Cell Carcinoma and Small Cell Carcinoma / 대한소화기내시경학회지

Neuroendocrine carcinoma of the stomach is an uncommon cancer with a high grade malignant behavior and a poor prognosis. The classification of gastric neuroendocrine carcinomas and its biologic characteristics remain controversial. It can be subdivided into the large cell and small cell variants based on its morphological characteristics. The low incidence of this tumor has contributed to the limited knowledge regarding its treatment and prognosis. We report here on two cases of primary neuroendocrine carcinomas of stomach, large cell and small cell carcinomas, respectively, along with a review of the literature.

A Case of Undifferenciated Large Cell Carcinoma of Lung Associated with Neurofibromatosis / 대한내과학회지

Neurofibromatosis also referred to as von Recklinghausen`s disease, is an autosomal dominant disease, which is characterized by cutaneous neurofibromas, cafe-au-lait spot, and axillary freckles. Although neruofibromatosis is a congenital disorder, the pulmonary manifestation become evident in adulthood. Approximately 15percent of patients with cutaneous lesions have intrathoracic neurofibromas. In some patients with neurofibromatosis, the lungs are the seat of interstitial fibrosis, leiomyoma, and bullous lesion, meningocele or less commonly lung cancer. The association of neurofibromatosis and lung cancer is rare, A 47-year-old man, who was a heavy smoker, was admitted to our hospital because of hemoptysis. Since cafe-au-lait sopts, diffuse pigmentation and multiple neurofibromatosis were observed on the skin, he was considered to have von Recklinghausen`s disease. Chest X-ray film showd extensive hazy density affecting all of his lung field, and minimal peribronchial infiltratin in his left lower lung field. Chest CT showed that near total consolidative lesions were present of right middle lobe. Also, some patchy infiltration were present in his right lower lobe and some of left lower lobe. Histoathological examination of the percutaneous lung biopsy specimen demonstrated that he had undifferentiated large cell carcinoma. The Authors have experienced a case of neurofibromatosis combined with undifferntiated large cell carcinoma. A brief review of related literature was conducted.

Large Cell Carcinoma of the Lung: An analysis of clinical features and survival / 대한치료방사선과학회지

This is a retrospective review of 33 patients with large cell lung carcinoma treated at Yonsei University Cancer Center between Jan. 1985 and Dec. 1989. Of the thirty-three patients, twenty eight were men and five women. Median age was 59 years. Large cell undifferentiated carcinoma was the most common pathologic type, 78.8%. Twenty one of thirty three patients had far advanced diseases, stage IIIB-IV at the time of initial diagnosis. Pleural effusion was initially presented in 12 patients, and SVC syndrome appeared in 5 patients. As to location of the primary tumor, 19(57.6%) appeared in the right lung and 14 (42.4%) in the left. Patients with a centrally located primary tumor mass were nearly the same as those peripherally located (17 vs. 16). Fifteen of thirty three patients developed metastasis involving not only bone, brain, the opposite lung, adrenal gland but also soft tissue, skin, pancreas and appendix. Treatment was individualized with 19 treated radically and 14 palliatively. After treatment, only two patients showed a complete response. Long term survival was observed in 4 patients: 1 (24 mo.), 2 (41 mo.) and 1 (54 mo.). The overall 2 year survival rate was 14.3% while the median survival time was 6.0 months. Through the analysis of the various factors affecting survival, we observed that pleural effusion-absent group and complete response group had a statistical significant better survival rate (p<0.01).