ABSTRACT
To better practice the Deepening Standardization Reform Plan,announced by the State Council,to promote the leadership of standard in healthy development of preventive medicine and public health,the Chinese Preventive Medicine Association (CPMA) established the Standardization Committee of Chinese Preventive Medicine Association (SC-CPMA).The SC-CPMA was responsible for the work of standardization developments of CPMA,including review of project's qualification and proposal,pre-qualification and qualification review of standard,publicity and training of standard,evaluation of standard implementation,review of standard,and public response monitoring of the standard.At December 13,2018,CPMA published two group standards,the Technical specification of data processing for large population-based cohort study (T/CPMA 001-2018) and Technical specification of data security for large population-based cohort study (T/CPMA 002-2018).This was the first time that a group standard was published by CPMA and produced for large cohort study's establishment and research.These two standards were the milestones for public health areas and the academic achievement of team,leading by Dr.Li Liming,after decade of research and practice.The two standards were developed based on the China Kadoorie Biobank Study and aimed to formulate professional standards and standardized operation procedures that met the nationals conditions,with strong operability and generality of population cohort establishments.The group standards were also aimed to guide the establishments for other population-based cohort studies to maximum support the decision making and practice for disease control and prevention.The increasing disease burden of non-communicable disease (NCD) became severe public health problem and the etiology for NCD is complex.Large cohort studies,which became more popular recently,played an important role in observation and explanation of NCD etiology and risk factors.Under the current situation with growing number of large cohort studies,it is necessary to have a standard,which could be shared and used to guide other professional as critical scientific protocols.CPMA was committed to promoting the development of group standards in the field of public health,and supporting the implementation of the Healthy China Strategy.
ABSTRACT
To better practice the Deepening Standardization Reform Plan,announced by the State Council,to promote the leadership of standard in healthy development of preventive medicine and public health,the Chinese Preventive Medicine Association (CPMA) established the Standardization Committee of Chinese Preventive Medicine Association (SC-CPMA).The SC-CPMA was responsible for the work of standardization developments of CPMA,including review of project's qualification and proposal,pre-qualification and qualification review of standard,publicity and training of standard,evaluation of standard implementation,review of standard,and public response monitoring of the standard.At December 13,2018,CPMA published two group standards,the Technical specification of data processing for large population-based cohort study (T/CPMA 001-2018) and Technical specification of data security for large population-based cohort study (T/CPMA 002-2018).This was the first time that a group standard was published by CPMA and produced for large cohort study's establishment and research.These two standards were the milestones for public health areas and the academic achievement of team,leading by Dr.Li Liming,after decade of research and practice.The two standards were developed based on the China Kadoorie Biobank Study and aimed to formulate professional standards and standardized operation procedures that met the nationals conditions,with strong operability and generality of population cohort establishments.The group standards were also aimed to guide the establishments for other population-based cohort studies to maximum support the decision making and practice for disease control and prevention.The increasing disease burden of non-communicable disease (NCD) became severe public health problem and the etiology for NCD is complex.Large cohort studies,which became more popular recently,played an important role in observation and explanation of NCD etiology and risk factors.Under the current situation with growing number of large cohort studies,it is necessary to have a standard,which could be shared and used to guide other professional as critical scientific protocols.CPMA was committed to promoting the development of group standards in the field of public health,and supporting the implementation of the Healthy China Strategy.
ABSTRACT
Long-term follow-up for end point is an extremely important and arduous task in large population-based cohort studies, which is also the key to the success of large cohort studies. Thus, the fundamental question of the achievements above is how to construct a large population- based cohort in a standardized way. The Chinese Preventive Medicine Association coordinated experienced researchers from Zhejiang Provincial Center for Disease Control and Prevention and other professional institutes to write up the group standard entitled Technical specification of long-term follow-up for end point in large population-based cohort study (T/CPMA 002-2019). The standard is drafted with principles of emphasizing the scientific, normative, applicability, and feasible nature. This group standard recommended the follow-up target population, time, content, methods, quality control, and indicators assessment. The standard aims to guide the large population-based cohorts that have been or intended to be established in China, including national cohorts, regional population cohorts, and special population cohorts, hence, to improve domestic scientific research level and the international influence, and to support decision-making and practice of disease prevention and control.
ABSTRACT
Large population-based cohort study is an important resource for population disease prevention and control, the results of which provide scientific basis for individualized treatment and precise prevention, and it is also the key strategic content of precision medicine. The Chinese Preventive Medicine Association coordinated experienced researchers from the Chinese Academy of Medical Sciences and other professional institutes to write up the group standard entitled Technical specification of management for field investigation in large population-based cohort study (T/CPMA 001-2019). Based on the research of large population-based cohort study in China and the principle of scientific, normative, applicable, and feasible, the standard proposed six aspects of management requirements including institutional arrangement, personnel composition, equipment, materials, documents and finance, as well as the basic requirements of the on-site investigation, the requirements of each position and the overall quality control requirements, etc.. The standard aims to guide the large population-based cohorts that have been or intended to be established in China, including national cohorts, regional population cohorts, and special population cohorts, hence to improve scientific research level, accelerate scientific research output and provide localization basis for disease prevention and control in China.
ABSTRACT
To unravel the genetic mechanisms of disease and physiological traits, it requires comprehensive sequencing analysis of large sample size in Chinese populations. Here, we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative (CASPMI) project launched by the Chinese Academy of Sciences, including the de novo assembly of a northern Han reference genome (NH1.0) and whole genome analyses of 597 healthy people coming from most areas in China. Given the two existing reference genomes for Han Chinese (YH and HX1) were both from the south, we constructed NH1.0, a new reference genome from a northern individual, by combining the sequencing strategies of PacBio, 10× Genomics, and Bionano mapping. Using this integrated approach, we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1. In order to generate a genomic variation map of Chinese populations, we performed the whole-genome sequencing of 597 participants and identified 24.85 million (M) single nucleotide variants (SNVs), 3.85 M small indels, and 106,382 structural variations. In the association analysis with collected phenotypes, we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males. Moreover, significant genetic diversity in MTHFR, TCN2, FADS1, and FADS2, which associate with circulating folate, vitamin B12, or lipid metabolism, was observed between northerners and southerners. Especially, for the homocysteine-increasing allele of rs1801133 (MTHFR 677T), we hypothesize that there exists a "comfort" zone for a high frequency of 677T between latitudes of 35-45 degree North. Taken together, our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine.