Improving effect of Tujia Medicine Tianzhusan on learning and memory impairment caused by cerebral ischemia / 中草药

Objective: To investigate the therapeutic effects of Tianzhusan (TZS) on the related indexes of learning and memory impairment of rats with vascular dementia (VD) caused by cerebral ischemia. Methods: The rats' models were prepared by a permanent ligation of the bilateral common carotid arteries. After ig administration for 63 d, the learning and memory abilities of rats were observed with Morris water maze, the pathological changes in hippocampus were detected with HE staining and Nissl staining, and the expression levels of microtubule associated protein-2 (MAP-2) and synaptophysin-1 (SYN-1) in hippocampus were evaluated by immunohistochemistry. Results: The latent period of rats in the model group was longer than that in the control group obviously (P < 0.05). However, the latent period of rats in Nimodipine and TZS groups was shortened after ig administration by different degrees. HE staining showed that the neuronal cells appeared necrosis and deformation in CA1 and CA3 areas of hippocampus of rats in the model group, while Nimodipine and TZS could reduce these injuries. Nissl staining showed that TZS could increase the number of Nissl bodies in CA1 and CA3 areas of hippocampus. Nimodipine and TZS could improve the expression level of MAP-2 in hippocampus. The rats in the model group had a high expression of SYN-1 in CA1 and dentate gyrus areas, but a low expression in CA3 area. Nevertheless, TZS could increase the expression of SYN-1 in CA3 area. Conclusion: TZS could improve the learning and memory abilities of VD rats by relieving the damage of neuronal cell, promoting the synthesis of neurotransmitters, and regulating the expression levels of MAP-2 and SYN-1.

Observation of Anti-epileptic Behavior on Catgut Implantation at Acupoint in Epilepsy Rats Induced by Penicilin / 中国中医药信息杂志

Objective To study the effects of catgut implantation at acupoint on epileptic attack behavior in experimental epilepsy rats. Methods 40 rats were randomly divided into model group, catgut implantation group, western medicine group and acupuncture group. Making the acute epilepsy model by intraperitoneal injection of penicilin in rats after pretreatment, observed the latent period and the performance of epilepsy seizures within 70 minutes after intraperitoneal injection of penicilin. Results The latent period of catgut implantation, western medicine and acupuncture groups was prolonger than model group (P 0.05). The times of epileptic attack behavior in catgut implantation group including nodding/tail-flick, beard shaking, anterior/hind limb tic, systemic tic and jump was less than the model group respectively (P

Effect of Pingchuang Capsule on Sensitized Guinea Pigs' Asthma Latent Period and Lung Function / 浙江中医药大学学报

[Objective]Explore the asthma-relieving of Pingchuang Capsule on asthma guinea pigs, its mechanism as well. [Method] Observe the sensitized guinea pigs' changes on latent period of asthma and liver function. [Result] Pingchuang Capsule can markedly prolong the latent period of guinea pigs(P

Outcome of Primary Total Hip Arthroplasty in Patients with Osteonecrosis of the Acetabulum after Previous Pelvic Irradiation / 대한정형외과학회잡지

PURPOSE: To describe the results of Total Hip Artroplasty (THA) treatment, and to analyze the risk factors related to the early failure of acetabular components in irradiated hips. MATERIALS AND METHODS: Between January 1990 and January 2000, eighteen primary total hip arthroplasties in twelve patients were treated at our hospital. The mean follow-up period was fifty-eight months. The acetabular components were of hemispherical design with an ingrowth surface in fourteen cases and roof rings in four cases. The risk factors analyzed: age, total radiation dose, onset of symptoms after irradiation (4 years), and the risk of failure of acetabular components after THA. RESULTS: The latent period was significantly related to the survival rate with a cutoff point of four years (p=0.03). Adjusting for age, total radiation dose, and component type, the risk of failure was fifteen times higher (95% confidence interval: 1.03-227.44) in patients with a disease onset latency of > or => or =4 years than in those with a latent period of <4 years. CONCLUSION: It is suggested that any arthroplasty might be unwise if the portal of irradiation includes the acetabulum and the latent period of disease onset after irradiation exceeds four years.

Comparison of the Latent Period of Symptomatic Epilepsy after the Onset of Etiologic Brain Lesions in Children / 대한소아신경학회지

PURPOSE: The common etiologies of most symptomatic epileptic children are congenital brain malformation, hypoxic injury, CNS infection and traumatic brain injury, etc. These brain lesions are often followed by a latent period of variable durations before the appearance of epilepsy. This research was designed to study the latent period of each etiology. METHODS: Subjects were 125 children with epilepsy who visited the Department of Pediatrics, Pusan National University Hospital between March 1993 and July 2002. We divided these patients into five groups according to etiologic brain lesions - congenital brain malformation(group 1), hypoxic brain injury(group 2), CNS infection(group 3), traumatic brain injury(group 4) and metabolic disorders or intoxication(group 5) - and compared the latent period of each patient group. RESULTS: The latent period of each patient group was as follows; 1.5 years(group 1), 1.7 years(group 2), 0.4 years(group 3), 2.9 years(group 4) and 0.4 years(group 5). There were significantly statistical differences in the latent periods among group 3, 4 and 5, between group 1 and 3, group 1 and 5, group 2 and 3, and group 2 and 5. CONCLUSION: The onset of epilepsy tends to appear relatively later after traumatic brain injury, while CNS infection and metabolic disorders cause the onset of epilepsy usually within 6 months.

Correction of Craniosynostosis Using Distraction Osteogenesis by Gradual Distraction

Craniosynostosis is the term that designates premature fusion of one or more sutures in either cranial vault or cranial base. Strip craniectomy had been recorded in the literature before the turn of the century, and remarkable improvements in the correction of the craniosynostosis have taken place. Various surgical methods including frontal bone advancement and cranial vault remodeling have been developed in an effort to correct craniosynostosis. However, the standardized surgical method has not yet been established. Distraction osteogenesis had been developed by Ilizarov to elongate bones without bone graft and the technique was developed so as to lengthen the long bones. Karp and McCarthy reported successful membranous bone lengthening with external devices and noted that cortical bone formed in the expanded area of the mandible. In the field of cranial vault, the technique has been successfully used by Sugawara and many efforts are made to improve cranial vault deformities. There are two possible modes of bone regeneration in case of patients for whom gradual distraction of cranial vault is performed. Bone regeneration of cranial vault may occur from the cut edges of calvaria(distraction osteogenesis) or from islands within the dura mater. We have experienced four patients with craniosynostosis who had undergone surgical correction using distraction device. Because we believed that latent period was not an important factor, we could early initiate distraction schedule. All patients obtained satisfactory results and no relapse was observed during the follow-up period. In conclusion, we believe that latent period would not be an important factor in distraction osteogenesis of cranial vault and the distraction osteogenesis by gradual distraction is useful for the correction of craniosynostosis.

Maternal and perinatal outcome of preterm premature rupture of the membranes at perinatal center, Philippine Children's Medical Center (A three-year retrospective study)

A retrospective study of seventy four patients with preterm premature rupture of the membranes admitted at Perinatal Center, Philippine Childrens Medical Center, was done. The mean gestational age at diagnosis of preterm premature rupture of the membranes was 31 weeks. The interval from rupture to delivery ranged from three days to sixty one days with a mean of 4.1 days. There was no correlation between gestational age at the time of rupture and latency period. Twenty patients received steroids and twenty received tocolytics. Twenty nine of the seventy four patients received antibiotics. There was no reported maternal mortality. The mean gestational age at the time of delivery was 32.48 weeks +/-2.3 weeks. The 74 patients resulted to 76 births. There were 3 neonatal deaths and 1 stillbirth. In patients 32 weeks, the perinatal survival rates was 25% while it was 94% with gestational age 32 weeks (p 0.05). There was no significant difference in the perinatal outcome among steroid and non-steroid groups and among antibiotic and non-antibiotic groups.