ABSTRACT
OBJECTIVE:To compare the quality control index between Jinzhen Suanzao teabag and decoction,and explore the alternative supplement of teabag to decoction. METHODS:The test sample solutions of Jinzhen Suanzao teabag and decoction were prepared by hot-maceration method and water-decoction method. The contents of water soluble extract and total flavonoids were de-termined and compared between 2 kinds of preparation. The leaching rates of teabag were investigated at different soak time(0,5, 10,15,20,25,30 min) to optimize soaking time. RESULTS:The average content of water soluble extract were 50.56% and 44.45%(P<0.05) respectively for the teabag and decoction. The total flavonoids content were 0.64 mg/g and 0.69 mg/g (P<0.05). The dissolution amount of teabag were increasing and leaching rate increased within first 20 min,and reached balance gradu-ally 25 min later. CONCLUSIONS:According to the convenience of use and results of each index,the difference in quality control index is not great between 2 kinds of preparation. Teabag can be as the supplement of decoction.
ABSTRACT
Objective: To prepare the pH-dependent astragalus polvsaccharides colon-specific spray drying powder, with the intention of controlling drug release in the colon. Methods: Eudragit S100 water dispersion was used as a carrier to prepare astragalus polvsaccharides colon-specific spray drying powder by spray drying method and the in vitro dissolution of spray drying powder was performed. The structure characteristics of spray drying powder was analyzed by SEM. Results: When the ratio of drug to Eudragit S100 was 1:10, the drug in simulated gastric fluid did not release nearly and the accumulative drug-release percent in vitro at 4 h was less than 30.0%; But in the simulated colonic fluid, the accumulated drug release percent reached 90.0% within 1 h. Conclusion: The astragalus polysaccharides colon-specific spray drying powder had the characteristics as a colon-specific delivery system. The preparation process is simple and feasible.