ABSTRACT
A rare complication of chronic lymphedema is development of cutaneous malignant tumors particularly cutaneous lymphomas. We report a case of primary cutaneous diffuse large B-cell lymphoma, leg type, associated with chronic lymphedema of the lower limbs. A literature review identified 12 additional cases of primary cutaneous lymphomas associated with chronic lymphedema. Chronic lymphatic stasis may cause a local dysfunction of the immune system that predisposes to the induction of neoplasia, cutaneous lymphomas in particular.
ABSTRACT
Los linfomas cutáneos de células B son un grupo heterogéneo de linfomas que se presentan en piel sin evidencia de compromiso extracutáneo al momento del diagnóstico y corresponden entre 20% al 25% de los linfomas cutáneos primarios. Presentamos un caso de un linfoma primario cutáneo difuso de células B grandes, tipo pierna en una anciana, con mala respuesta al tratamiento (AU)
Primary cutaneous B-cell lymphomas are a heterogeneous group of lymphomas occurring in the skin without extracutaneous involvement at time of diagnosis and constitute about 20-25% of primary lymphomas. A case of primary cutaneous diffuse large B-cell lymphoma, leg type, in an elderly woman with a poor response to treatment is reported (AU)
Subject(s)
Humans , Female , Middle Aged , Skin Neoplasms/pathology , Lymphoma, Large B-Cell, Diffuse/diagnosis , Palliative Care , RadiotherapyABSTRACT
El linfoma de células B del tipo de la pierna, es una neoplasia rara y agresiva, con características clínicas, morfológicas e inmunofenotípicas distintivas. Está clasificada dentro del grupo de linfomas cutáneos primarios de células B y se presenta en edades avanzadas, con predominio en mujeres y altas tasas de recurrencia. Presentamos el caso de una mujer de 63 años de edad, con diagnóstico clínico e inmunofenotípico de linfoma cutáneo de células B del tipo de la pierna.
Primary cutaneous B−cell lymphoma, leg type, is an uncommon and aggressive neoplasm with unique clinical features, morphology and immunophenotype. It is classified as a primary B−cell cutaneous lymphoma and it occurs in advanced age and women with high rates of recurrences. We present the case of a 63−year−old woman, with clinical and immunophenotypic diagnosis of primary cutaneous B−cell lymphoma, leg type.
O linfoma de células B do tipo da perna é uma neoplasia rara e agressiva, com características clínicas, morfológicas e imunofenotípicas distintivas. Está classificado dentro do grupo de linfomas cutâneos primários de células B e se apresenta em idades avançadas, com predomínio em mulheres e altas taxas de recorrência. Apresentamos o caso de uma mulher de 63 anos de idade, com diagnóstico clínico e inmunofenotípico de linfoma cutâneo de células B do tipo da perna.
Subject(s)
Humans , Middle Aged , Lymphoma, Primary Cutaneous Anaplastic Large Cell , Lymphoma, Follicular , Lymphoma, Large B-Cell, DiffuseABSTRACT
In the WHO-EORTC (World Health Organization-European Organization for Research and Treatment of Cancer) classification, the primary cutaneous B-cell lymphomas were divided into 4 groups: primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicle center cell lymphoma, primary cutaneous diffuse large B-cell lymphoma, other, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT). PCLBCL LT is known to have more aggressive clinical behavior and a worse prognosis than the other groups of primary cutaneous B-cell lymphomas. We report here on a case of PCLBCL LT in a 55-year-old male who presented witha multiple erythematous nodules on the right leg. After chemotherapy, the skin lesions had almost cleared, but afterward the tumor was revealed to have metastasized to the brain during 1 year.