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OBJECTIVE: To explore the correlation between obstructive sleep apnea-hypopnea syndrome (OSAHA) and elderly (≥80 year-old) hypertension (HP), and the effects of levamlodipine on antihypertensive effect of elderly patients with HP complicated with OSAHA. METHODS: A total of 90 elderly HP patients were analyzed retrospectively and divided into HP group (30 cases) and HP+OSAHA group (60 cases) according to whether accompanied by OSAHA or not. The latter was divided into HP complicated with mild OSAHA group (20 cases, HP+OSAHA1 group), hypertension complicated with medium OSAHA group (21 cases, HP + OSAHA2 group), HP complicated with severe OSAHA group (19 cases, HP + OSAHA3 group) according the severity of OSAHA. All patients were given Levamlodipine besylate tablet 2. 5 mg taken at a draught, qd, in the morning, for 4 weeks, while continuous positive pressure veritilation was given to treat the obstructive apnea in OSAHA patients. Neck circumference, BMI, apnea hypoventilation index (AHI), Sa02, SBP and DBP (daytime, evening and 24 h) were observed in each group 4 weeks later. The correlation of AHI and Sa02 with SBP and DBP was analyzed by Spearman rank correlation. RESULTS: Neck circumference, BMI, AHI, daytime SBP, evening and 24 h SBP and DBP of HP + OSAHA group were significantly higher than those of HP, while SaO2 of HP + OSAHA group was significantly lower than that of HP group. Neck circumference and BMI of HP+OSAHA2 group and HP+OSAHA3 group were significantly higher than those of HP group; the HP+ OSAHA3 group were higher than the HP+OSAHA2 group. SaO2 of HP+OSAHA2 group and HP+OSAHA3 group were significantly lower than that of HP group; the HP+OSAHA3 group was lower than the HP+OSAHA2 group. AHI, evening and 24 h SBP and DBP of HP+OSAHA group were significantly higher than 6those of HP group; the descending order was as follows: HP+OSAHA3 group>HP+OSAHA2 group>HP+OSAHA1 group. Daytime SBP of HP+OSAHA3 group was significantly higher than that of HP group, with statistical significance (P<0. 001); there was no statistical significance in daytime DBP among those groups (P>0. 05). Results of Spearman rank correlation analysis showed that evening and 24 h SBP and DBP were positively correlated with AHI (P<0. 001) and negatively correlated with SaO2 (P<0. 001). CONCLUSIONS: OSAHA can induce the significant increase of blood pressure in elderly HP patients. Levamlodipine has different influences antihypertensive effect of elderly patients with HP complicated with OSAHA. The drug should be adjusted according to the patient's condition.
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OBJECTIVE:To observe the clinical efficacy and safety of atorvastatin combined with levamlodipine besylate in the treatment of elderly patients with hypertension combined with carotid plaque. METHODS:160 elderly patients with hyperten-sion combined with carotid plaque were randomly divided into control group(80 cases)and observation group(80 cases). Control group orally received Atorvastatin tablet 3 mg,qd+compound reserpine tablets 2 tablets,tid;observation group was received Atorv-astatin tablet(the same dosage and usage with control group)+Levamlodipine besylate tablet 2.5 mg,qd. They were treated for 8 months. Antihypertensive efficacy,blood pressure,and carotid intima-media thickness (IMT) before and after treatment,and the incidence of adverse reactions in 2 groups were observed and recorded. RESULTS:The antihypertensive effective rate in observa-tion group was significantly higher than control group,with statistical significance(P0.05). After treatment,blood pressure and IMT levels in 2 groups were significantly lower than before,and observation group was lower than control group,with statistical significance(P0.05). CONCLUSIONS:Atorv-astatin combined with levamlodipine besylate shows good efficacy in the treatment of elderly patients with hypertension combined with carotid plaque,which can not only effectively control patients'blood pressure,but also improve atherosclerosis,reversing plaques and does not increase the incidence of adverse veactions.
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Objective To investigate the clinical effect of amlodipine combined with Telmisartan Capsules in the treatment of hypertension.MethodsThe patients with primary hypertension in 87 cases in the second hospital affiliated to Tianjin Medical University were divided into two groups.43 patients in control group were treated with amlodipine 2.5~5mg/d orally, 44 patients in the experimental group on the basis of combined with Telmisartan Capsules 40~80mg/d orally, the total course of treatment was eight weeks.The changes of blood pressure levels were compared before and after treatment, the effective rate of the treatment and adverse reactions after treatment, to evaluate the clinical efficacy of amlodipine combined with Telmisartan Capsules in the treatment of hypertension.ResultsAfter treatment, two groups of three blood pressure index were significantly decreased (P<0.05), compared with the control group, the experimental group of patients with treatment After treatment the blood pressure level is low(P<0.05).After eight weeks of treatment, the total efficiency of control group was 72.09%, the total efficiency of experimental group was 95.45%, the experimental group was higher than that in the control group (P<0.05) after treatment, patients in the control group with two cases of headache (4.65%), two cases of lower extremity edema (4.65%);the experimental group of two cases of vertigo (4.55%), three cases of joint pain (6.82%), there was no significant difference in total adverse reaction rate between the two groups.Conclusion Amlodipine combined with Telmisartan Capsules in the treatment of hypertension has good clinical effect.
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OBJECTIVE:To investigate therapeutic efficacy and safety of levamlodipine and telmisartan combined with hydro-chlorothiazide in the treatment of anti-dipper hypertension. METHODS:Totally 150 patients with anti-dipper hypertension were ran-domly divided into group A,B,C,with 50 cases in each group. Group A was given Telmisartan tablet 40 mg+Hydrochlorothiazide tablet 10 mg,once a day,in the morning. Group B was given Levamlodipine tablet 5 mg,once a day,in the night. Group C was given Telmisartan tablet(usage and dosage same as group A)+Hydrochlorothiazide tablet(usage and dosage same as group A)+Le-vamlodipine tablet(usage and dosage same as group B). Treatment courses of 3 groups lasted for 8 weeks. The changes of electro-lyte and 24 h ambulatory blood pressure were observed and compared among 3 groups before and after treatment. The incidence of adverse reactions was recorded. RESULTS:There was no statistical significance in the electrolyte indexes in 3 groups before and af-ter treatment(P>0.05). Before treatment,there was no statistical significance in 24 h blood pressure among 3 groups(P>0.05). Af-ter treatment,the 24 h blood pressure of the patients in the 3 groups after treatment was lower than before treatment,and group C was lower than that of the group A and group B(P0.05). CONCLUSIONS:Levamlodipine and telmisartan combined with hydrochlorothiazide show good therapeutic efficacy for anti-dipper hypertension,and can reduce 24 h blood pressure and effectively reverse anti-dipper rhythm with good safety.
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OBJECTIVE:To observe the clinical efficacy and safety of Ligustrazine injection,α-ketoacid combined with levam-lodipine in the treatment of chronic renal failure. METHODS:92 patients with chronic renal failure were randomly divided into ob-servation group(46 cases)and control group(46 cases). All patients received electrolyte,vitamins and essential amino acid,low salt,low fat,hypoglycemic and hypolipemic,anti-infection,correcting anemia and other conventional symptomatic treatment. Based on it,control group received 8 Compound α-ketoacid tablets,3 times a day + 1 Benzenesulfonic acid levamlodipine tablet, once a day. Observation group additionally received 150 mg Ligustrazine hydrochloride injection,adding into 250 ml 5% Glucose injection,intravenous infusion,once a day. The treatment course for both groups was 3 months. Clinical efficacy,and urea nitro-gen (BUN),serum creatinine (Scr),serum cystatin (CysC),low-density lipoprotein cholesterol (LDL-C),total cholesterol (TC),triglyceride (TG) levels before and after treatment and the incidence of adverse reactions in 2 groups were observed. RE-SULTS:The total effective rate in observation group was significantly higher than control group,the difference was statistically sig-nificant(P0.05). After treatment,BUN,Scr,LDL-C,TC and TG in 2 groups were significantly lower than before,and obser-vation group was lower than control group,CysC was significantly higher than before,and observation group was higher than con-trol group,the differences were statistically significant (P0.05). CONCLUSIONS:Based on conventional treatment,Ligustrazine injection,α-ketoacid combined with le-vamlodipine show obvious efficacy in the treatment of chronic renal failure,they can improve the renal functions,with good safety.
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OBJECTIVE:To observe the efficacy of levoamlodipine besylate combined with piracetam for vascular dementia(VD).METHODS:66 patients with VD were enrolled:33(treatment group) were assigned to receive Levoamlodipine besylate 2.5～5 mg q.d plus piracetam 0.8 g tid for 3 months,and another 33(control group) to receive piracetam 0.8 g tid plus basic treatment based on patients' blood glucose,blood pressure and blood lipid levels.The patients were given 3-month follow-up.Mini-Mental State Examination(MMSE),Activity of Daily Living Scale(ADL),Hasegawa Dementia Scale(HDS) and Wechsler Memory Scale(WMS) were used to evaluate the patient's cognitional function and mental state before and after treatment.RESULTS:MMSE,ADL,HDS,and WMS scores after treatment were(22.48?3.25),(25.16?8.96),(23.14?2.91),(71.14?19.01),respectively in treatment group versus(20.56?3.18),(29.74?13.01),(20.41?6.25),(60.35?20.60),respectively in control group.The treatment had a better improvement in symptoms than control group did and there was statistical difference between groups(P