ABSTRACT
OBJECTIVE:To provide reference for rational application of Levofloxacin hydrochloride injection in the clinic. METHODS:With reference to the package insert of Levofloxacin hydrochloride injection,the guiding principles of clinical use of antibiotics,by reviewing related literatures,based on the weighted TOPSIS methods,detailed rules for drug utilization review (DUR) of Levofloxacin hydrochloride injection were made. And then 100 archived medical records of Levofloxacin hydrochloride injection in the first half of 2014 were evaluated in respect of medication rationality based on these rules. RESULTS:Among 100 cases,relative proximity of 51 cases was more than 70%(51.0%);that of 37 was between 50%-70%(37.0%);that of 12 cases was between 30%-50%(12.0%). CONCLUSIONS:Established DUR method of Levofloxacin hydrochloride injection on the basis of weighted TOPSIS methods can be used to evaluate the rationality of drug use and promote more rational evaluation behavior. And the results indicate that unreasonable use of Levofloxacin hydrochloride injection is still common in the hospital.
ABSTRACT
OBJECTIVE:To study the compatible stability of Levofloxacin hydrochloride injection with Inosine in sodium chloride injection. METHODS:Levofloxacin hydrochloride injection was mixed with Inosine in sodium chloride. Then UV spectrophotometry was applied to detect the change of content at 20 ℃ within 6 hours. The change of appearance,pH value,content of mixture,insoluble particle were also observed. RESULTS:The change of appearance,pH value,content of mixture,insoluble particle in mixture was not found out. CONCLUSION:Levofloxacin hydrochloride injection mixing with Inosine in sodium chloride injection is suitable for clinical use within 6 h.
ABSTRACT
OBJECTIVE: To study the photostability of the levofloxacin hydrochloride injection. METHODS: The content of levofloxacin hydrochloride was determined and its UV spectra changes were observed after being lighted by three different light sources-the UV light, the sunlight and the natural light for different periods of time. Whether there is any decomposed product or not was determined by TLC. RESULTS: There were decompositions of levofloxacin hydrochloride injection subjected to illumination from three light resources, with that under the sunlight decomposed faster; Rf value under TLC of the decomposed product was found to be 0.72. CONCLUSION: Levofloxacin hydrochloride injection should be kept away from UV light, the sunlight and the natural light.