Protective Effect of Ligustrazine on Ischemia-Reperfusion Injury of Rat Liver / 中国普外基础与临床杂志

Objective To explore the protective effect of ligustrazine on the ischemia-reperfusion injury of rat liver. Methods Ninety-six healthy SD rats were divided randomly into three groups: sham operation group, ischemia-reperfusion group(I/R group) and ischemia plus ligustrazine reperfusion group(therapy group).The plasm ALT,AST and LDH were measured before operation,at thirty minutes,six hours and twenty-four hours after operation. One week survival and liver pathological change of every group were observed, and the hepatocyte apoptosis index was measured simultaneously.Results One week survival of therapy group was higher than that of I/R group ( P