ABSTRACT
【Objective】 To investigate the main causes of blood donor deferral in domestic blood center. 【Methods】 The causes of donor deferral were classified into 12 categories as previous medical history, drug use, alcohol consumption, menstrual period, underweight, abnormal blood pressure, abnormal body temperature, abnormal hemoglobin (Hb), lipemic blood, positive hepatitis B surface antigen (HBsAg), elevated alanine aminotransferase (ALT) and others according to the comparison indicators of Asia-Pacific Blood Network (APBN) and the national standard Blood Donor Health Examination Requirements. The relevant data of the top 3 causes of donor deferral, voluntarily reported by the members of Practice Comparison Working Group of China’s Mainland Blood Collection and Supply Institutions from 2014 to 2019, were collected and a histogram was generated. 【Results】 The median donor deferral rate of 20 domestic blood centers from 2014 to 2019 was 12.14%, with the lowest at 0.18% and highest at 32.32%, respectively. The top three causes for donor deferral were elevated ALT, abnormal Hb and abnormal blood pressure in year 2014, 2015, 2018 and 2019; elevated ALT, lipemic blood and abnormal blood pressure in 2016; elevated ALT, abnormal Hb, and lipemic blood in 2017. 【Conclusion】 The main causes of donor deferral were elevated ALT, abnormal Hb, abnormal blood pressure and lipemic blood.
ABSTRACT
【Objective】 To analyze the causes and preventive measures of lipemic blood in voluntary blood donors. 【Methods】 Data of 12 000 voluntary blood donors donated at our blood station from January 2018 to June 2020 were retrospectively analyzed. The incidence, discarding rate and causes of lipemic blood were investigated, and preventive measures were formulated. 【Results】 384(3.20%) out of the 12 000 blood samples were lipemic blood, while mild, moderate and severe lipemic blood constituted 181, 148 and 55 cases, respectively. The incidence of lipoemia in males(4.22%) was higher than that in females(1.52%). The incidence of lipoemia in 26~45 and 36~45 age population was 4.75%, which was higher than that in 18~25 age group(0.62%). The incidence of lipoemia was the lowest in donors with mass index(kg/m2) <18.5, followed by 18.5~24.9 and >30 (P<0.05). The incidence of lipemic blood among first-time blood donors(4.38%) was higher than that in repeated donors(2.31%), higher in blood donation collected during 13: 00 to 17: 00(3.54%) than 9: 00 to 12: 00 a. m.(2.73%), also higher in group blood donors(4.01%) than street blood donors(1.56%)(P<0.05). The free Hb of red blood cells in moderate and severe group was higher than that in mild group immediate after preparation and 7 days after preparation (P<0.05). 【Conclusion】 There was a significant tendency for the incidence of lipemic blood in voluntary blood donors, which causes blood discarding. The publicity of blood donation, pre-donation consultation and advice on reasonable diet should be boosted to reduce the discarding rate of lipemic blood and improve the use of blood.
ABSTRACT
En el Banco de Sangre Provincial de Cienfuegos se incluye, además de las pruebas reguladas en Cuba para la selección de los donantes de sangre, la prueba de lipemia predonación. Un plasma con apariencia turbia es causa de exclusión transitoria del donante. A fin de evaluar la eficacia diagnóstica de esta prueba se realizaron dos estimaciones visuales del plasma en busca de turbidez, la primera antes de donar y la segunda en la unidad de plasma obtenida a partir de la sangre total colectada, esta última utilizada como prueba de referencia para este estudio. Ambas observaciones fueron realizadas por el mismo observador siguiendo un protocolo establecido. Como parte del estudio, la presencia de una prueba de lipemia positiva predonación no constituyó causa de exclusión de donantes. Se calculó la sensibilidad y especificidad diagnóstica, el valor predictivo positivo (VPP) y el valor predictivo negativo (VPN), además la eficiencia de la prueba dentro de un intervalo de confianza del 95 por ciento. Se obtuvo el 98,4 por ciento de especificidad, el 80 por ciento de sensibilidad, así como el 66,6 por ciento de valor predictivo positivo y el 99,0 por ciento de valor predictivo negativo, con el 95,7 por ciento de eficiencia diagnóstica. La prueba resulta útil en la selección de donantes de sangre y se recomienda su uso en todas las dependencias de colecta de sangre que cuenten con las condiciones técnicas para su realización...
In addition to the Cuban regulated tests for donor selection, the Cienfuegos provincial blood bank uses a predonation lipemia test. The present study evaluates the diagnostic efficacy of this test. Two visual estimates of plasma for turbidity were performed: the first before donation and the second one to the plasma unit obtained from the whole blood collected, this one used as a reference test for this study. Both observations were made by the same observer following an established protocol. As part of the study, the presence of a positive test predonation lipemia was not cause for excluding donors. Diagnostic sensitivity and specificity, positive predictive value (PPV) and negative predictive value (NPV) and efficiency of the test within a confidence interval of 95 percent were calculated. We obtained 98,4 percent specificity, 80 percent sensitivity and 66,6 percent positive predictive value and 99,0 percent negative predictive value, with 95,7 percent diagnostic accuracy. The test is useful for the selection of blood donors and we recommended its use in all blood collection services having technical conditions for its fulfillment...
Subject(s)
Humans , Blood Donors/ethics , Lipoprotein Lipase , Donor Selection/methods , Clinical Laboratory Techniques/methodsABSTRACT
Hypertriglyceridemia is an emerging risk factor for atherosclerosis, coronary heart disease and pancreatitis in the developing countries like India. It can be familial or acquired. Hypertriglyceridemia associated with hyperglycinemia and carnitine deficiency is rarely seen. We report a case of 3 months old infant with low birth weight admitted for failure to thrive and lower respiratory tract infection. He was screened for hypertriglyceridemia and inborn error of metabolism. Serum was lipemic with triglyceride level-1236 mg%, Cholesterol-220 mg%, Amino acid Glycine (789 umol/L) was elevated, Fatty acids like Acetylcarnitine (4.16 umol/L), Octadecanoyl carnitine (0.16 umol/L) were found to be decreased. There is no family history of hyperlipidaemia or consanguineous marriage. History, clinical examination and blood reports points towards transient infantile hypertriglyceridemia. Reasons for high glycine level and carnitine deficiency could not be established. Further investigations like mass spectrometry and mutational screening for genetic defects are necessary for confirmatory diagnosis. Meanwhile infant was treated with lipid lowering agents, medium chain fatty acids and carnitine supplements.
ABSTRACT
Fructooligosaccharide (FOS) is a prebiotic, becoming apparent for its therapeutic role for diseased conditions like CHD, hypertension, diabetes and obesity. CHD and hypertension are one of the most prevalent NCD’s encountered in diabetic adults. Present study aims to assess the effect of FOS supplementation in type 2 diabetic adults on their lipemic, biophysical parameters and gut microflora parameters. A cross-sectional study was designed with 65 adult type 2 diabetics enrolled from Health clinic of The M.S. University of Baroda, Gujarat. All the subjects were randomly divided into two groups control and experimental. The experimental group was given 10 g of fructooligosaccharide and compared with the controls for lipemic parameters, hypertension and fecal counts in terms of lactic acid bacteria, bifidobacteria and enteric pathogen. Eight week supplementation of FOS resulted in an appreciable reduction in serum TC, TG and LDL levels by 10%, 4.9% and 7.8% respectively. A significant reduction (p<0.05) in systolic blood pressure was also observed as a result of FOS supplementation in the experimental group. A decline was seen in TC/HDL, LDL/HDL and non-HDL by 10.4%, 7.6% and 6.6% respectively (p<0.05, p<0.001). Gut microbiota values exhibited a significant increment in fecal log10 counts of Lactic acid bacteria and bifidobacteria by 9.3% and 10.9% respectively (p<0.001) while a significant reduction by 4.8% (p<0.001) was observed for Enteric pathogen. These outcomes revealed an efficacy of FOS in reducing serum lipid parameters, systolic BP and improving the gut microbiota in type 2 diabetic adults.