ABSTRACT
Objective To evaluate the efficacy and safety of Liqifuwei oral liquid for prophylaxis of chemotherapy induced-constipation through a randomized controlled trial.Methods Cancer patients who met the inclusion criterias were randomly assigned to the treatment group and the control group by random number table.Liqifuwei oral liquid was prescribed 20 ml per tid from the first day of chemotherapy in the treatment group,the control group accepted the conventional treatment.Incidence and degree of chemotherapy inducedconstipation,degree and duration time of abdominal distension,anorexia and diarrhea were compared by criteria of NCI-CTC 3.0.Results A total of 100 patients were eligible,including 50 patients in the treatment group and 50 patients in the control group respectively.Incidence rate of chemotherapy induced-constipation was 48 ％ (24/50) and 98 ％ (49/50) (P ＜ 0.000 1),all patients were grade 1-3 constipation,no grade 4 and grade 5 constipation (P =0.036).Incidence rate of abdominal distension was 36 ％ (18/50) and 70 ％ (35/50)(P =0.001 3),abdominal distension degree (P =0.033),duration time of abdominal distension was (2.22±1.48)days and (3.43±1.60) days (P =0.01).Incidence rate of anorexia was 56 ％ (28/50) and 90 ％ (45/50)(P ＜ 0.000 1),there was no significance different of anorexia degree (P =0.818).One patient in treatment group underwent mild diarrhea.Conclusion The prophylaxis of Liqifuwei oral liquid for chemotherapy induced-constipation and abdominal distension is effective,which deserves large-sample studies and clinic application.
ABSTRACT
OBJECTIVE:To establish a RP-HPLC method for content determination of costunolide in Liqifuwei oral liquid.METHODS:The assay was performed on a Luna C 18 column by UV detector at the wavelength of225nm with methanol-water(72∶28)as the mobile phase at the flow rate of1.0ml/min.RESULTS:The amount of costunolide was linear with its area over the range from0.2?g～2.0?g(r=0.9996),the average recovery was98.4%(RSD=0.85%).CONCLUSION:The present method is convenient,sensitive and accurate with good reproducibility and can be used for the quality control of Liqifuwei oral liquid.