ABSTRACT
Objective: To use the liquid phase coprecipitation method for preparing gemcitabine magnetic nanoparticles to the pouch, and explore the preparation process in a number of conditions. Methods: The effect of different stirring speeds, Fe3+/ Fe2+ ratio, pH, temperature of Fe3O4 powder and emulsification condition, ultrasonic time, curing temperature on the preparation of targeted magnetic nanoparticles were observed. Results: The preparation of Fe3O4 nanoparticles was as follows: 800 r / min of stirring speed, 1.7: 1 Fe3+/Fe2+ ratio, pH=9, the reaction temperature of 60 °C, and the 5: 40 water / oil compared, ultrasonic time of 10 min, 100 °C curing temperature. Conclusion: Fe3O4 powder with small particle size, high purity, and no agglomeration are prepared, the stability of the gemcitabine magnetic nanoparticles capsule is good.
ABSTRACT
Objective To use the liquid phase coprecipitation method for preparing gemcitabine magnetic nanoparticles to the pouch,and explore the preparation process in a number of conditions. Methods The effect of different stirring speeds,Fe3+/Fe2+ratio,pH,temperature of Fe3O4 powder and emulsification condition,ultrasonic time,curing temperature on the preparation of target?ed magnetic nanoparticles were observed. Results The preparation of Fe3O4 nanoparticles was as follows:800 r/ min of stirring speed,1.7∶1 Fe3+/Fe2+ratio,pH=9,the reaction temperature of 60℃,and the 5∶40 water/oil compared,ultrasonic time of 10 min, 100℃curing temperature. Conclusion Fe3O4 powder with small particle size,high purity,and no agglomeration are prepared,the stability of the gemcitabine magnetic nanoparticles capsule is good.