ABSTRACT
La cirrosis determina un importante problema de salud en el mundo y forma parte de las 10 primeras causas de muerte. Cerca de 2.500 personas fallecieron en Ecuador en el 2016 a consecuencia de cirrosis hepática, es la séptima causa de muerte en nuestro país, según datos del 2016 del Instituto Nacional de Estadísticas y Censos. Las principales causas de cirrosis descritas en el mundo son la infección crónica por virus hepatitis C, virus hepatitis B, alcohol, enfermedades biliares y enfermedad hepática grasa no alcohólica. La cirrosis se caracteriza patológicamente por distorsión de la arquitectura hepática debido a fibrosis hepática extensa y regeneración nodular. Existen diversos criterios de imagen para el diagnóstico de cirrosis, que incluyen: cambios morfológicos hepáticos y signos de hipertensión portal. En el hospital Carlos Andrade Marín, el 6 de mayo del 2016, se realizó el primer trasplante hepático. Hasta septiembre del 2018, se han realizado 54 trasplantes hepáticos de donante cadavérico (31 hombres, 23 mujeres)
Cirrhosis determines an important health problem in the world, and is one of the top 10 causes of death. About 2,500 people died in Ecuador in 2016 as a result of liver cirrhosis, is the seventh cause of death in our country, according to 2016 data from the National Institute of Statistics and Census. The main causes of cirrhosis described in the world are chronic infection with hepatitis C virus, hepatitis B virus, alcohol, biliary diseases and non-alcoholic fatty liver disease. Cirrhosis is pathologically characterized by distortion of the hepatic architecture due to extensive liver fibrosis and nodular regeneration. There are several image criteria for the diagnosis of cirrhosis, which include: Morphological Changes in the Liver and Signs of Portal Hypertension. In the hospital Carlos Andrade Marín, on May 6, 2016, the first liver transplant was performed, until September 2018, 54 liver transplants from cadaveric donor (31 men, 23 women) were performed.
Subject(s)
Humans , Male , Female , Tomography, X-Ray Computed , Liver , Liver Cirrhosis , Diagnosis , Elasticity Imaging TechniquesABSTRACT
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.