Relationship between expression of MMP-9, p53 and the clinicpathological in primary hepatocarcinoma / 中国基层医药

Objective To investigate the expression of MMP-9, p53 protein in primary hepatocarcinoma (PHC) and the relationship between the clinicpathological in PHC. Methods The expression of MMP-9 and p53 in 74 eases with PHC and microvessel density(MVD) were detected by immunohistochemistry,the clinical pathological parameters were also analyzed. Results In hepato-cellular carcinoma, the expression of MMP-9 and p53 were closely related to MVD, tumor size, aggressive behavior(vascular metastasis and tumor envelope) ( P < 0.05 ). The positive correlation was found between the expression of two factors in PHC. Conclusion MMP-9 and p53 might be impor-tant markers in the carcinogenesis,progression and prognosis of PHC.