Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies. However, the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression. Here, we propose a self-amplifying logic-gated gene editing strategy for gene/H2O2-mediated/starvation multimodal cancer therapy. In this approach, a hypoxia-degradable covalent-organic framework (COF) is synthesized to coat a-ZIF-8 in which glucose oxidase (GOx) and CRISPR system are packaged. To intensify intracellular redox dyshomeostasis, DNAzymes which can cleave catalase mRNA are loaded as well. When the nanosystem gets into the tumor, the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx, which amplifies intracellular H+ and hypoxia, accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target cells. These tandem reactions deplete glucose and oxygen, leading to logic-gated-triggered gene editing as well as synergistic gene/H2O2-mediated/starvation therapy. Overall, this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

Cronología / Chronology

Esta cronología es una idea del psicoanalista e investigador francés Théo Lucciardi y fue publicada originalmente en el número 3 de la revista LAPSUS NUMÉRIQUE. Su autor ha preparado esta versión actualizada a 2023 especialmente para este número de Aesthethica. La secuencia, que va desde la invención de la rueda hasta la IA generativa, permite detenernos en los grandes hitos del desarrollo científico tecnológico y a la vez advertir ve el grado de aceleración de la última década. Se pueden reconocer allí varios de los temas que integran la agenda contemporánea en materia de bioética y que están presentes en este número de la revista. Algunos de ellos son cruciales para la lectura ético-analítica que proponemos, como la vigencia de la lógica booleana, la actualización del Test de Turing o el porvenir de la IA y el Chat GPT

This chronology is an initiative of the French psychoanalyst and researcher Théo Lucciardi and was originally published in number 3 of the LAPSUS NUMÉRIQUE magazine. Its author has prepared this updated version to 2023 especially for this issue of Aesthethica. The sequence, which goes from the invention of the wheel to generative AI, allows us to stop at the great milestones of technological scientific development and at the same time notice the degree of acceleration of the last decade. Several of the issues that make up the contemporary agenda in bioethics and that are present in this issue of the magazine can be recognized there. Some of them are crucial for the ethical-analytical reading that we propose, such as the validity of Boolean logic, the updating of the Turing Test or the future of AI and Chat GPT

Aplicación de sistemas fuzzy para la toma de decisiones del Plan Paso a Paso: análisis de los indicadores para la comuna de Valdivia / Artificial intelligence fuzzy system for the design of confinements during quarantines

BACKGROUND: Different modalities of quarantines were one of the main measures implemented worldwide to avoid the spread of SARS-CoV2 virus. AIM: To analyze and compare retrospectively the implementation of the Step- to-Step plan devised by the Chilean Ministry of Health during the pandemic. To propose a decision-making path based on an artificial intelligence fuzzy system to determine confinements in specific territories. MATERIAL AND METHODS: The Step-to-Step Plan threshold values such hospital network capacity, epidemic spreading, testing and contact tracing capability were modeled using fuzzy numbers and fuzzy rule-based systems. RESULTS: Ministry of Health's decision-making opportuneness were unrelated with the Step-to-Step Plan indicators for deconfinement. Such disagreements undermined epidemiological indicators. CONCLUSIONS: Using an artificial intelligence system could improve decision-making transparency, emergency governance, and risk communication to the population.

Gait phase recognition in intelligent above-knee prosthesis based on fuzzy logic algorithm / 中国康复理论与实践

ObjectiveAiming at the need of control strategy switching of intelligent above-knee prosthetic, taking the plantar pressure of human walking as the research object, and based on fuzzy logic algorithm, a gait phase division method based on plantar pressure of prosthetic is proposed. MethodsThree flexible force sensors installed on the soles of the false feet were used to collect the plantar pressure information of the test object under three different walking modes (walking on the flat road, walking downhill and walking down the stairs). After data fusion processing, it was sent to the fuzzy logic controller, and the recognition results were output according to the IF-THEN rule, the scale and sensitivity factor. ResultsThrough the testing of five healthy people as substitute, the results showed that the accuracy of gait phase recognition for walking on the flat road, walking down the stairs and walking downhill were (95.3±2.4)%, (81.5±6.3)% and (90.7±3.5)%, respectively. ConclusionThe accuracy of recognition basically meets the requirements in this project. This method can be applied in the gait phase recognition of intelligent above-knee prosthetic.

Statistical analysis logic and expression specifications of cohort and case-control studies / 中华麻醉学杂志

Cohort and case-control studies are important types of study design in clinical and epidemiological researches. Although they are both methods to study associations between an exposure and a disease, their core logic is completely different.In order to evaluate the association between an exposure and an outcome, cohort studies group the populations by the research factor (exposure or not), and compare the event rate of the outcome in exposure and control groups through follow-up. Cohort studies are sequential from cause to effect. On the contrary, case-control studies derive cause from effect. Case-control studies group the populations by the outcome (occurrence or not), and compare the distributions of the exposure in case and control groups through retrospective investigation or collection of exposure information from historical records. This paper declares the logic that should be followed in statistical analysis of these two types of studies, as well as the specifications that should be followed in formulating statistical analysis plans and reporting results. The aim of this paper is to enhance the scientific nature of the research and improve the readability of the literature.

Sports and health integration: logic, dilemma and alleviation / 中华行为医学与脑科学杂志

By combing out the historical development logic of sports and health integration and the current development achievement, the underlying logic of sports and health integration is described systematically in multiple dimensions, and the prominent dilemmas in development are analyzed as follows: lack of residents' health literacy, excessive dependence on medical treatment, low bridging of talent team construction, lack of the guidance of funds centralization, insufficient financial support, imperfect management system and mechanism, and unspecific departmental collaboration.The strategies for solving the problems are as follows: strengthening the integration of sports science and clinical medicine, consolidating the technical integration of sports prescription and clinical standardization process, further improving the business integration of exercise intervention and clinical treatment, and enhancing the industrial integration of sports products and medical treatment.

On the Formation Logic and World Significance of A Community of Common Health for Mankind / 中国医学伦理学

The concept of a community of common health for mankind profoundly expresses China’s important proposition of promoting the health and well-being of people in various countries and jointly maintaining global public health security, which has a distinct formation logic. The idea of a community of common health for mankind is rooted in the "real community" theory of Marxist, reflecting its value orientation in the field of global health, and highlighting the new era’s inherent requirements of "adhering to the people first". It is an organic unity of theoretical logic, value logic, and practical logic. The construction of a community of common health for mankind gathers broad consensus, highlights the distinct theme of world peace and development, responds to international concerns, and provides Chinese proposals and contributes Chinese strength for governing global public health, practicing multilateralism, and promoting the construction of new international relations.

Intrinsic "self-consistent" phenomenon based on holistic view of traditional Chinese medicine / 中国中药杂志

The fundamental principle of traditional Chinese medicine(TCM) is holism, and it is crucial for TCM to address the key issue of the "holistic view" of Chinese herbal medicine. While the overall regulatory effects of Chinese herbal medicine have been widely recognized, the holistic internal logic of individual ingredients of Chinese herbal medicines require further clarification. In order to comprehensively understand the mechanism of action of Chinese herbal medicine, this paper combined the holistic view of Chinese herbal medicine with differentiation thinking to explore the intrinsic logical relationships within Chinese herbal medicine. Starting from the perspective of the coexistence of multiple components in Chinese herbal medicine, this paper systematically examined the "self-consistent" phenomenon within single Chinese herbal medicine. This phenomenon refers to the consistent or opposing actions of various components in terms of their physical and chemical properties, pharmacokinetic effects, biological effects, flavors and properties, and TCM efficacy. The paper summarized various logical relationships of syndrome differentiation exhibited by the same Chinese herbal medicine, analyzed the underlying reasons, and focused on analyzing external factors affecting the "self-consistent" phenomenon in the efficacy of Chinese herbal medicine, aiming to better elucidate the theoretical basis of the pharmacological effects of Chinese herbal medicine, further enrich the scientific connotation of the holistic view of Chinese herbal medicine, and provide theoretical guidance for the preparation process, compatibility patterns, and formulation design of Chinese herbal medicine.

Analysis of physical health test results of college students using fuzzy logic as an evaluation method / Análise dos resultados nos testes de saúde física dos estudantes universitários utilizando lógica fuzzy como método de avaliação / Análisis de los resultados en las pruebas de salud física de los estudiantes universitarios utilizando lógica difusa como método de evaluación

ABSTRACT Objective: Based on the evaluation method with fuzzy integrals, this paper analyzes the results of physical health tests of college students. Methods: Principal component analysis was used to extract the psychological factors. The evaluation model was organized into three levels to evaluate the physical health of college students. Results: The physical health status of University Q students is below average. Most of the students' physical examination results are concentrated in the passing areas, and few students have an excellent to good ratio. Conclusion: The fitness assessment model of university students, based on an assessment with fuzzy integrals, has certain generalizability and applicability. The established index system and the comprehensive evaluation model are suitable for thoroughly evaluating each student and comprehensive fitness evaluation of all boys and girls in a class or college. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Objetivo: Com base no método de avaliação com integrais fuzzy, este documento analisa os resultados dos testes de saúde física dos estudantes universitários. Métodos: Foi utilizada a análise de componentes principais para extrair os fatores psicológicos. O modelo de avaliação foi organizado em três níveis para avaliar a saúde física dos estudantes universitários. Resultados: O estado de saúde física dos estudantes da Universidade Q está abaixo da média. A maioria dos resultados dos exames físicos dos estudantes está concentrada nas áreas de aprovação, e poucos estudantes têm uma proporção excelente e boa. Conclusão: O modelo de avaliação da aptidão física dos estudantes universitários, baseado em uma avaliação com integrais fuzzy, tem certa generalização e aplicabilidade. O sistema de índice estabelecido e o modelo de avaliação abrangente não só são adequados para avaliação abrangente de cada estudante, mas também para avaliação abrangente da aptidão física de todos os meninos e meninas de uma classe ou faculdade. Nível de evidência II; Estudos terapêuticos - investigação de resultados de tratamento.

Resumen Objetivo: Basándose en el método de evaluación con integrales difusas, este artículo analiza los resultados de las pruebas de salud física de los estudiantes universitarios. Métodos: Se utilizó el análisis de componentes principales para extraer los factores psicológicos. El modelo de evaluación se organizó en tres niveles para evaluar la salud física de los estudiantes universitarios. Resultados: El estado de salud física de los estudiantes de la Universidad Q está por debajo de la media. La mayoría de los resultados de los exámenes físicos de los estudiantes se concentran en las zonas de aprobado, y son pocos los que tienen una proporción excelente y buena. Conclusión: El modelo de evaluación de la aptitud física de los estudiantes universitarios basado en una evaluación con integrales difusas tiene cierta generalizabilidad y aplicabilidad. El sistema de índices establecido y el modelo de evaluación integral no sólo son adecuados para la evaluación integral de cada estudiante, sino también para la evaluación integral de la aptitud de todos los chicos y chicas de una clase o colegio. Nivel de evidencia II; Estudios terapéuticos - investigación de resultados de tratamiento.

Soul Seat- Realization of Spiritual Being

We are spiritual beings with human experience, but how can we realize that we are spiritual beings is a tedious task for which the whole world is trying for ages. Spiritual world starts from Kundalini, Chakras, 5 Tatva etc origin of all connects us with our spiritual self but it's very complicated and needs lot of hand holding from an enlightened Guru. We have created a structure where a simple analogy when connected to few breathing exercises and touching the point again and again with Beejmantra invokes the spiritual being inside. Thus the spiritual being outside the body can be identified and thus can be connected. While studying neuroscience several micro networks were observed in the human body by scientists, human health has deep connection with immunity, inner peace, justice and happiness. Behavior has become increasingly prominent in psychological theory of biological models, especially in neuro-imaging tools development. Thus one can realize that every particle bears intelligence and there is a cumulative intelligence which governs the course of action of one single particle, creator of Intelligence is the spiritual being who created the cosmos. This thought when applied time and again connected everyone on a divine knowledge path where everything starts connecting and the person becomes a master of all traits. Connecting soul seat increased conversion of air, fire & water to Pran, Tej & Oaj and reduced Vaat, Pitta & Kapha thus Bala increased and body attained strong immunity against diseases and longevity. Resistance against disease increased on physical, mental, emotional & spiritual level. Thus connecting with soul seat, its understanding and how and where it influences the society is the scope of the study.

Independent risk factors of type III acute acquired concomitant esotropia: A matched case–control study

Purpose: To investigate the risk factors and surgical design for type III acute acquired concomitant esotropia (AACE). Methods: In this retrospective, matched, case–control study, 51 patients developed type III AACE between March 2018 and September 2020, and the control group consisted of 60 patients matched by age and refractive power during the same period. A history of the duration of near work per day and the use of glasses were reviewed, and the refractive power of both eyes, deviation angles at both near and far vision, visual function, and treatment options were analyzed. Additionally, the distance from medial rectus insertion to the limbus was measured in surgical patients. The data were analyzed by logistic regression analysis. Results: We found that 99.96% of the patients and 91.67% of the controls had myopia. Of these, 60.8% and 20.0%, respectively, did not wear glasses for near work. Twelve patients were treated with a prism and 39 were treated surgically. The average time devoted to near work per day was 7.24 and 3.7 h by the patients and controls, respectively. Univariate logistic regression analysis showed that increased hours of near work per day and near work without the use of spectacles were associated with the incidence of type III AACE. Multiple logistic regression analysis revealed that increased hours of near work per day and near work without the use of glasses were independent risk factors for AACE. Conclusion: Increased hours of near work per day and uncorrected myopia in near work are independent risk factors for type III AACE

Racionalidad pugilistica y supremacismo médico-legal. Una controversia argumental sobre la violencia consensuada

Este artículo presenta una revisión crítica de algunos de los principales argumentos esgrimidos por detractores y defensores en el denominado debate sobre el boxeo. Se examinan las posturas planteadas por destacados representantes del activismo médico-legal a favor de la abolición total del boxeo y se confronta particularmente el mito de la naturaleza salvaje e irracional de dicho deporte. Se contrasta tal concepción con el abordaje etnográfico propuesto por Lois Wacquant y su mentor, Pierre Bourdieu, sobre la existencia de una racionalidad pugilística forjada en el habitus corporal del boxeador. Se recorren aspectos importantes del problema como es el hecho de que la Pedagogía, a través de la cual se enseña a boxear, dista de ser consciente, reflexiva, teorizadora e intelectualista (lo cual alimenta la apariencia de una supuesta ausencia de formación y cultivo de un saber que es eminentemente práctico). Asimismo, se muestra la dualidad de la argumentación médica al moverse sutilmente del plano epistémico al plano ético-moral y las implicaciones que tal opacidad arrastra. El objetivo del artículo no es cerrar la controversia en detrimento de las preocupaciones del sector médico-sanitario, sino mostrar la complejidad filosófica que le subyace.

Este artigo apresenta uma revisão crítica de alguns dos principais argumentos apresentados por adversários e apoiadores no chamado debate do boxe. Ela examina as posições apresentadas por destacados representantes do ativismo médico-legal em favor da abolição total do boxe e enfrenta em particular o mito da natureza selvagem e irracional do esporte. Esta concepção é contrastada com a abordagem etnográfica proposta por Lois Wacquant e seu mentor, Pierre Bourdieu, sobre a existência de uma racionalidade pugilística forjada no hábito corporal do boxeador. Aspectos importantes do problema são explorados, como o fato de que a pedagogia através da qual o boxe é ensinado está longe de ser consciente, reflexiva, teorizante e intelectual (o que alimenta a aparência de uma suposta ausência de treinamento e cultivo de um conhecimento que é eminentemente prático). Ela também mostra a dualidade da argumentação médica ao passar sutilmente do plano epistêmico para o plano ético-moral, e as implicações que tal opacidade implica. O objetivo do artigo não é fechar a controvérsia em detrimento das preocupações do setor médico-sanitário, mas mostrar a complexidade filosófica que lhe está subjacente.

This article presents a critical review of some of the main arguments put forward by detractors and defenders in the so-called boxing debate. It examines the positions put forward by prominent representatives of medico-legal activism in favor of the total abolition of boxing and particularly confronts the myth of the savage and irrational nature of the sport. This conception is contrasted with the ethnographic approach proposed by Lois Wacquant and his mentor, Pierre Bourdieu, on the existence of a pugilistic rationality forged in the boxer's bodily habitus. Important aspects of the problem are discussed, such as the fact that pedagogy, through which boxing is taught, is far from being conscious, reflective, theorizing and intellectualistic (which feeds the appearance of a supposed absence of training and cultivation of a knowledge that is eminently practical). It also shows the duality of medical argumentation by subtly moving from the epistemic plane to the ethical-moral plane and the implications that such opacity entails. The aim of the article is not to close the controversy to the detriment of the concerns of the medical-health sector, but to show the philosophical complexity that underlies it.

Preliminary study on dicentric chromosome identification algorithm based on artificial intelligence technology / 中华放射医学与防护杂志

Objective:To explore artificial intelligence technology and propose an algorithm for automatic identification of dicentric chromosomes to realize fast and high-throughput biodosimetry. In order to solve the time-consuming and laborious problem of manual analysis of dicentric chromosomes.Methods:Combining artificial intelligence technology and image processing technology, based on MATLAB software, algorithms like image preprocessing, threshold segmentation algorithm, binarization processing, area identification algorithm, convolutional neural network algorithm and double centripetal recognition algorithm were applied. A fuzzy membership function was defined to describe the degree of each chromosome belonging to a dicentric chromosome, and the discrimination threshold was set to realize the automatic identification of dicentric chromosomes.Results:Through the test on 1 471 chromosome images, compared with manual recognition, the detection rate of dicentric chromosomes cells of this algorithm reached 70.7%.Conclusions:This algorithm method carries out a preliminary study on the automatic identification of dicentric chromosomes with good result.

A Review of Open Defecation (OD) In Indonesia and The Control with Logic Model

@#In 2015, Indonesia was ranked as the second-highest, with a percentage of 12.9%. Open Defecation Free (ODF) in Indonesia is still a problem, 33 out of 34 provinces in Indonesia are still not 100% verified as ODF. The purpose of this study is to make a management control of OD behaviour in Indonesia. This study’s literature was collected using Google Scholar and Pubmed search engines by entering keywords open defecation Indonesia, and buang air besar sembarangan. From review of published literature, it is found that several factors cause people to practice OD, namely environmental, socio-cultural, and economic factors. These factors become the basis for making OD model control with a logic model. The program was made with a button-up approach carried out through several activities, namely approaches to community leaders, youth, and local communities, monitoring potential areas for OD practice and cross-sector coordination, and making regional regulations.

Achieving successful aging through exercise: intrinsic logic and path selection / 中华老年医学杂志

Physical exercise helps promote successful aging, meaning that physical exercise can promote the physical health of the elderly and achieve healthy aging.It can also improve the mental health of the elderly and help achieve active aging.In addition, it can enhance social participation of the elderly and help achieve productive aging.To take advantage of the benefits of exercise for successful aging, the selection of paths should follow the principles of evidence-based exercise and scientifically proven exercise to avoid ineffective exercise or other negative effects of exercise, give priority to the natural environment to maximize exercise benefits, consider harmonious integration into social situations to improve the sense of social participation of the elderly, and formulate specific exercise plans to offer customized exercise prescriptions to realize the best results.

The Practical Dilemma and Solutions of Embedding the Red Doctor’s Spirit into the Cultivation Field of Medical Students’ Humanistic Quality / 中国医学伦理学

Embedding the red doctor’s spirit into the cultivation field of medical students’ humanistic quality is a win-win strategy for creating the excellent doctor 2.0 plan in the new era and inheriting the red genes. Based on the in-depth interpretation of the morphological logic of embedding the red doctor’s spirit into the field of cultivating medical students’ humanistic quality, from the three dimensions of beginning, presence and development, this paper clearly captured many barriers, conflicts and contradictions faced in the process of the red doctor’s spirit embedded in the cultivation field of medical students’ humanistic quality. It is also necessary to break through the practical dilemma by creating the entry card and carrier of the red doctor’s spirit, stabilizing the field of educating people with the red doctor’s spirit, and expanding the development space of educating people with the red doctor’s spirit, so as to win and unite medical students and promote the implementation of the Healthy China strategy.

Real-Time Energy Management System for Microgrids

Abstract: Microgrids (MD) is a new technology to improve efficiency, resilience, and reliability in the electricity sector. MD are most likely to have a clean energy generation, but the increase of microgrids with this kind of generation brings new challenges for energy management (EMS), especially concerning load uncertainties and variation of energy generation. In this context, this study has the main objective to propose a method of how to attend this matter, verifying the difference between the day before and real-time. The EMS proposed analyses the MD in real-time, calculating the deviation between dispatched and what was predicted to happen in the operation point in a three-dimensional analysis approach, considering renewable energy generation, battery State of Charge (SOC) and load curve. The system categorized the deviation in three possible quantities (small, medium, or high) and it acts accordingly. For the Next Operation Point predictor are used an artificial neural network (ANN) methodology. For the Decision Support System, it's used a fuzzy logic system to adjust the next operation point, and it uses a mixed-integer linear programming (MILP) approach when the deviation is too high, and the dispatched operation is unfeasible. Simulations with real data and information of a pilot project of MD are carried out to test and validate the proposed method. Results show that the methodology used to attend the matters of uncertainties and variation of energy generation. A reduction of operational cost is observed in the simulations.

The importance of logical thinking for clinical nursing care / La importancia del pensamiento lógico para el cuidado de enfermería clínica / A importância do pensamento lógico para o cuidado clínico de enfermagem

ABSTRACT Objective To present a reflection on the importance of logical thinking for clinical nursing care. Method Reflection paper Reflection The exercise of an effective clinical care brings with it the need for logical thinking and adequate reasoning for safe and effective nursing practices. Therefore, training based on philosophical principles that encourage the increase of logical and critical thinking is considered unquestionable, ensuring professionals the systematization of assistance with the application of the nursing process based on scientific understanding and strong arguments supported by the path of truthfulness, morality, ethics and critical self-reflection in order to value clinical practices. Final considerations The importance of logical thinking for nursing care is ratified here, supporting nursing care systematization and the nursing process stages. Thus, nurses can use clinical reasoning skills to deliver a humane, ethical, and effective professional performance.

RESUMEN Objetivo Presentar una reflexión sobre la importancia del pensamiento lógico para el cuidado de enfermería. Método Estudio de reflexión. Reflexión El ejercicio de un cuidado clínico efectivo trae consigo la necesidad de un pensamiento lógico y un razonamiento adecuado para prácticas de enfermería seguras y efectivas. Por tanto, se considera incuestionable la formación basada en principios filosóficos que propicien el pensamiento lógico y crítico, asegurando la sistematización de la asistencia y el proceso de enfermería basados en la comprensión científica y argumentos sólidos sustentados en el camino de la verdad, moral, ética. y autocrítica, con el fin de favorecer la valorización de prácticas clínicas. Consideraciones finales Se confirma la importancia del pensamiento lógico para el cuidado de enfermería, apoyando la sistematización del cuidado y las etapas del proceso de enfermería. De esta manera, las enfermeras pueden utilizar las habilidades de razonamiento clínico, proporcionando un desempeño profesional humano, ético y eficaz.

RESUMO Objetivo Apresentar uma reflexão sobre a importância do pensamento lógico para o cuidado clínico de enfermagem. Método Estudo de reflexão. Reflexão Pensar em exercer o cuidado clínico eficaz remete à necessidade de um pensamento lógico e raciocínio adequado para a realização de práticas de enfermagem seguras e eficazes. Para tanto, considera-se inquestionável a formação baseada nos princípios filosóficos que estimulem o incremento do pensamento lógico e crítico, assegurando aos profissionais a sistematização da assistência com aplicação do processo de enfermagem a partir do entendimento científico e argumentos sólidos abalizados pelo caminho da verdade, moral, ética e autocrítica, de forma a favorecer a valorização das práticas clínicas. Considerações finais Ratifica-se a importância do pensamento lógico para o cuidado de enfermagem fundamentando a Sistematização da Assistência de Enfermagem e as etapas do Processo de Enfermagem. Desta forma, o enfermeiro pode fazer uso do raciocínio clínico propiciando uma atuação profissional humana, ética e eficaz.

O senso de pertencimento na cocriação de valor nos serviços esportivos: evidências do fitness business / El sentido de pertenencia en la cocreación de valor en los servicios deportivos: evidencias del fitness business / The sense of belonging in the value co-creation in sports services: evidence from the fitness business

A jornada de experiências do cliente de fitness é observada nesta pesquisa exploratória, na qual 15 consumidores de duas academias orientadas para serviço, não membros de redes, sendo uma em Alphaville (Barueri/SP) e a outra na Savassi (Belo Horizonte/MG), participaram de entrevistas semiestruturadas. Das mais de três horas de gravação e uma centena de páginas de transcrição, foi possível propor um modelo conceitual de como o entrelaçamento das dimensões tangível, atendimento técnico e pertencimento permitem ao cliente a cocriação de valor na experiência de uso da academia. Concluiu-se que 1) os serviços também têm uma dimensão tangível; 2) apesar de toda a preparação acadêmico-tecnicista da equipe, os usuários querem coproduzir suas experiências; 3) o sentimento de pertencimento, além de engajar na cocriação de valor, é uma dimensão que pode aliviar qualquer desconforto advindo das experiências nas outras dimensões. A importância do pertencimento pode ser moderada pela autoeficácia do usuário.(AU)

La jornada de experiencias del cliente de fitness se observa en esta investigación exploratoria, donde 15 consumidores de dos gimnasios orientados al servicio, que no forman parte de cadenas, uno en Alphaville (Barueri/SP) y otro en Savassi (Belo Horizonte/MG), participaron en entrevistas semiestructuradas. Las más de tres horas de grabación y cien páginas de transcripción, se logró proponer un modelo conceptual de cómo el entrelazamiento de las dimensiones tangibles, servicio técnico y pertenencia permiten al cliente la cocreación de valor en la experiencia de uso del gimnasio. Se concluyó que 1) los servicios también tienen dimensión tangible; 2) a pesar de toda la experiencia académico-técnica del equipo, los usuarios quieren coproducir sus experiencias; 3) el sentimiento de pertenencia, además de involucrar en la cocreación de valor, es una dimensión que puede aliviar cualquier malestar proveniente de las experiencias en las otras dimensiones. La importancia de la pertenencia puede ser moderada por la autoeficacia del usuario.(AU)

The fitness customer experience journey is observed in this exploratory research, in which 15 consumers from two service-oriented gyms, not members of chains, one in Alphaville (Barueri/SP) and the other in Savassi (Belo Horizonte/MG), participated in semi-structured interviews. From more than 3 hours of recording and a hundred pages of transcription, it was possible to propose a conceptual model of how the tangible, technical service and belonging dimensions intertwine each other, allowing the gym customer to co-create value in their experience of usage. It was concluded that 1) services also have a tangible dimension; 2) despite all the academic-technical staff preparation, users want to co-produce their experiences; 3) the feeling of belonging, in addition to engaging in the value co-creation, is a dimension that can alleviate any discomfort arising from experiences in the other dimensions. The user's self-efficacy can moderate the importance of belonging.(AU)

Integración de la filosofía de Charles Peirce en la Ciencia de la Información / Integration of Charles Peirce's philosophy into information science

Este artículo tuvo como objetivo comprender la integración de la filosofía de Charles Peirce en la Ciencia de la Información. Desde el punto de vista metodológico, se trata de una investigación cualitativa y cuantitativa con el uso de técnicas bibliométricas. Los datos bibliográficos se recopilaron de cuatro bases de datos, dos específicas de Ciencias de la Información: Bibliotecas y Resúmenes de Ciencias de la Información de ProQuest - LISA y la base de datos de referencia de artículos de revistas en Ciencias de la Información; y dos multidisciplinarias: Scopus y Web of Science. Los resultados muestran que la filosofía Peirceana se está consolidando como una contribución teórica importante en las investigaciones y publicaciones de Ciencias de la Información, considerando el número relativamente significativo (114) de publicaciones recuperadas de las bases de datos antes mencionadas. Estos trabajos abordan el pragmatismo en estudios sobre gestión del conocimiento, sistemas de información, filosofía de la información, así como en la organización del conocimiento, especialmente relacionados con la comprensión o el proceso inferencial de indexación en sistemas de información. El artículo concluye que existe un interés creciente entre la comunidad científica de las Ciencias de la Información por desarrollar la filosofía de Peirce de una manera holística, no limitada al primer nivel de la semiótica peirceana, la gramática especulativa, ya que también incluye estudios que profundizan en la inferencia, proceso vinculado a la Lógica Pura(AU)

The purpose of the study was to understand the integration of Charles Peirce's philosophy into information science. From a methodological point of view, it is a qualitative and quantitative study based on bibliometric techniques. The bibliographic data were obtained from four databases, two specifically related to information sciences: ProQuest - LISA Information Sciences Libraries and Abstracts, and the reference database for articles from information sciences journals; and two multidisciplinary databases: Scopus and Web of Science. Results show that Peircean philosophy is gradually consolidating as an important theoretical contribution in information sciences studies and publications, considering the relatively significant number (114) of publications retrieved from the aforementioned databases. These studies address pragmatism in research about knowledge management, information systems, information philosophy and knowledge organization, particularly as related to understanding or the inferential indexing process in information systems. The article concludes that there is a growing interest by the information sciences scientific community to develop Peirce's philosophy in a holistic manner, not limited to the first level of Peircean semiotics and speculative grammar, for it also includes studies dealing with inference, a process related to pure logic(AU)