ABSTRACT
BACKGROUND: Long-acting antimicrobial material Is a new polymer activator of organoslllcon quaternary ammonium salt and has obvious advantages In anti-Infection. OBJECTIVE: To investigate the effects of Jieyoushen, a long-acting antimicrobial material, on pathogenic distribution and serum inflammatory factors in patients with indwelling catheters. METHODS: A total of 200 male patients with indwelling catheter who received treatment during January 2014 to January 2018 in Hainan West Central Hospital, China were Included In this study. These patients were aged 35-55 years and were randomly divided Into two groups: A control group (n=100) and an observation group (n=100). Patients In the control group were given routine urethral orifice nursing. Patients in the observation group were sprayed with long-acting antimicrobial material “Jieyoushen” on the urethral orifice, catheter and catheter bag interface. Infection was detected at 1, 3, 5 and 7 days after catheterization. The changes of pathogenic bacteria and serum inflammatory factors in two groups were analyzed at 7 days after catheterization. This study was approved by the Medical Ethics Committee, Hainan West Central Hospital, China (approval No. 2013120602). RESULTS AND CONCLUSION: Compared with the control group, the Infection rates of the patients In the observation group decreased significantly at 1, 3, 5 and 7 days after catheterization (P < 0.05). Twenty pathogenic bacteria were Isolated In patients of the control group, Including 13 Gram-positive bacteria (65.0%) and 7 Gram-negative bacteria (35.0%). Seven pathogenic bacteria were Isolated In patients of the observation group, including 5 Gram-positive bacteria (71.4%) and 2 Gram-negative bacteria (28.6%). Compared with before indwelling catheter, serum levels of interleukin-1ß, interleukln-2, homocysteine, and procalcltonin Increased significantly in each group after catheterization (P < 0.05). After catheterization, serum levels of above-mentioned factors in the control group were significantly higher than those In the observation group (P < 0.05). These results suggest that long-acting antimicrobial material “Jieyoushen” can effectively reduce the Infection rate of pathogenic bacteria and lower serum levels of Inflammatory factors In patients with Indwelling catheter.
ABSTRACT
Objective The prevention effect of CAUTI by long-acting antibacterial material JUC was evaluated by meta analysis.Methods China digital hospital library full-text database,Chinese biomedical literature CD database,China hosptial knowledge database (CHKD) in China national knowledge internet (CNKI),VIP information Chinese science and technology periodical database were retrieved to fully collect the literature from 1995 to 2012 regarding JUC's prevention effect of CAUTI.The inclusion and exclusion standard of literature was made,and the effect index was made from the literature.Two researchers collected the literatures independently,and the included literatures were meta-analyzed by Review Manager 4.2 software,and the risk difference of infection rate and 95％ CI were calculated in both the treatment group and control group.Those literatures which could not be meta-analyzed were performed descriptive analysis to evaluate the efficacy of JUC objectively.Results 20 related articles were retrieved,including 1 multicenter randomized control study,18 monocentric randomized control studies,and 1 uncontrolled study.3172 cases were included with 1526 cases in control group (usual care) and 1646 cases in treatment group (usual care with JUC).The difference between the two groups is significant (RD =-0.15,95％ CI:-0.18 ～-0.13,P ＜ 0.05).Conclusions Long-acting antibacterial material JUC can diminish the incidence of CAUTI significantly.
ABSTRACT
0.05).Conclusion:Compared with traditional dressing,JUC has similar effects on circumcisions in the aspects of isolating operative incisions,long-acting antisepsis and preventing infection of incisional wound.