ABSTRACT
Objective:To compare the clinical effect of domestic and imported omeprazole injection in the treatment of peptic ulcer bleeding.Methods:According to the random sequence generated by the computer,118 patients who were treated in digestive department of our hospital from April 2013 to May 2015 were randomly divided into 2 groups,59 cases in each group.The control group was given treatment of imported drug losec,while the study group was given treatment of domestic drug aoxikang,and two groups were treated continuously for 7 days.The incidences of gastrointestinal reactions,dizziness and palpitations,the average treatment time,and clinical therapeutic effects were compared,in addition,the costs of treatment in the two groups were analyzed.Results:There were no significant differences in the incidences of gastrointestinal reactions,dizziness and palpitations and the average treatment time between the study group and the control group (P＞0.05).There was no significant difference between the two groups in the treatment effect after rank sum test (P＞0.05).The total effective rates (96.61％ vs 94.91％) were equivalent,the differences were not statistically significant (P＞0.05),but the costs of using domestic drugs were lower than that of imported drugs.Conclusion:The clinical curative effects of domestic aoxikang and imported losec in treatment of peptic ulcer bleeding have no significant difference,which can have a good therapeutic effect,but the economy of aoxikang is more better.
ABSTRACT
OBJECTIVE:To evaluate the therapeutic effect of triple therapy of clarithromycin,losec plus amoxicillin on eradiation of Hp METHODS:65 patients with duodenal ulcer and Helicobacter pylori infection were divided into two groups:Therapy group(n=32) receiving triple therapy (clarithromycin 500mg,losec 20mg and amoxicillin 1 000mg b i d )for one week with prolongation of use of losec for one week more;Control group(n=33) receiving losec 20mg and amoxicillin 1 000mg in the same manner of administration as therapeutic group The Hp was detected with rapid urease test and immunohistochemical method before and 4 wks after treatment RESULTS:The eradiation rate in therapy group(90 6%)was significantly higher than that in control group(69 7%) Side-effects were rarely found in both groups CONCLUSION:Triple therapy of clarithromycin,losec and amoxicillin is effective,safe and tolerable in eradiating Hp