ABSTRACT
Objective To study the effects of lovastatin in the therapy of primary hypercholesterolemia on insulin sensitivity,vascular endothelial function and microcirculation in patients with coronary heart disease.Methods Forty-five patients,diagnosed as coronary heart disease and primary hypercholesterolemia,were treated by lovastatin for 8 weeks.Serum lipids,fasting plasma glucose (FPG),fasting insulin(FINS),nitric oxide(NO),endothelin(ET),6-keto-prostacyclin F 1?(6-keto-PGF 1?),thromboxane B 2(TXB 2) and nail-fold microcirculation (NFM) were measured and the score value of NFM and insulin sensitivity(IS) index were calculated in treatment group before and after 4-week and 8-week treatment with lovastatin.Forty healthy persons were taken as control.Results In treatment group,ET,TXB 2,and the score value of NFM were higher and NO,6-keto-PGF 1? and IS index were lower than those in control group.After 4-week lovastatin treatment,compared with baseline value,ET,TXB 2,and the score value of NFM significantly decreased,which were 63.19?18.72 vs 53.16?15.23 (P