ABSTRACT
[Abstract] Objective To study the therapeutic effect and responding time of low-flow oxygen combined with fosinopril on treatment of acute plateau heart disease. Methods Ninety young male officers and soldiers, diagnosed as acute plateau heart disease after rushing into the plateau (Ali region of Tibet, 4300 m) from the plain area and admitted to the Shiquanhe Medical Station in Ali Military Division from Sep. 2017 to Apr. 2018, were recruited in present study. All the subjects were randomly divided into 3 groups: group A were treated with low-flow oxygen (2 L/min, 60 min, twice a day), group B were treated with fosinopril (10 mg/d), and group C were treated with low-flow oxygen (2 L/min, 60 min, twice a day) combined with fosinopril (10 mg/d). Echocardiography was performed 2, 4 and 6 weeks after treatment to detect the pulmonary artery inner diameter (PAD), inner diameter of right outflow ventricular tract (ROVT), mean pulmonary arterial pressure (MPAP) and right ventricular Tei index (RV-Tei), the test results were then compared among the 3 groups to evaluate the therapeutic effect. Results Two weeks after treatment, the PAD, ROVT, MPAP and RV-Tei in group C [(21.66±3.49) mm, (25.81±2.33) mm, (22.37±2.78) mmHg and (0.24±0.05)] were significantly lower than in group A and group B [(28.37±3.75) mm and (27.29±2.91) mm; (31.25±5.27) mm and (30.34±5.66) mm; (28.25±4.17) mmHg and (27.11±4.94) mmHg; and (0.33±0.08) and (0.32±0.05)] with statistical differences (P0.05). Four weeks after treatment, the PAD, ROVT, MPAP and RV-Tei in group B and group C [(22.21±1.76) mm and (21.17±1.97) mm; (25.29±3.71) mm and (24.30±1.99) mm; (23.91±2.63) mmHg and (21.03±3.17) mmHg; and (0.23±0.06) and (0.23±0.05)] were significantly lower than in group A [(25.09±3.75) mm; (29.38±3.06) mm; (27.87±3.71) mmHg; and (0.29±0.05)] with statistical differences (P0.05). Six weeks after treatment, for PAD, ROVT, MPAP and RV-Tei no significant difference existed among group A, group B and group C [(22.71±2.86) mm, (21.29±2.56) mm, (20.39±2.03) mm; (24.08±3.51) mm, (23.15±3.08) mm, (23.02±2.31) mm; (23.42±1.79) mmHg, (22.88±2.77) mmHg, (21.72±2.49) mmHg; and (0.23±0.04), (0.22±0.06), (0.22±0.06)], and all the measured values reached normal level. Conclusion Low-flow oxygen combined with fosinopril therapy is more effective in curing acute plateau heart disease, and in preventing right heart failure caused by plateau heart disease.
ABSTRACT
PURPOSE: The purpose of this study was to provide a basis for non-humidified low flow oxygen by nasal cannula and to provide a guide for consistent care in nursing practice. METHODS: A methodological study on the development of guidelines with experts' opinions on collected items, framing PICO questions, evaluating and synthesizing texts which were searched with the key words (low flow oxygen, nasal cannula, humidification of oxygen, guideline) from web search engines. RESULTS: Of the 45 researched texts on the web, 9 texts relevant to the theme were synthesized and evaluated. All patients with humidified or non-humidified oxygen therapy reported that they had no discomfort. CONCLUSION: The results indicate that there are no tangible grounds for patients' perceived differences between the humidified and non-humidified oxygen under 4L/min supplied by nasal cannula. with oxygen. Therefore, non-humidification oxygen therapy is strongly advised when suppling under 4L/min oxygen by nasal cannula (recommended grade A).