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Objective To determine the association of asymptomatic sexually transmitted infections (STIs) with high-risk human papillomavirus (hrHPV) in cervical squamous intraepithelial lesions and neoplasms. Methods From July 2017 to July 2018, 320 hrHPV-positive and 160 hrHPV-negative women in The First Affiliated Hospital of Xi'an Jiaotong University were divided into normal+low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL)+ invasive cervical cancer (ICC) subgroups, respectively, based on their pathological cervical lesion grades. Cervical brush specimens including Ureaplasma urealyticum (UU) and its serotypes, Mycoplasma hominis (MH), Mycoplasma genitalium (MG), Chlamydia trachomatis (CT), and hrHPV were amplified and hybridized using PCR kits (Hybribio Biochemistry Co., Ltd.). The differences between groups were examined by the chi-squared test, continuity correction and Logistic regression. Results The overall infection (at least one of the non-hrHPV pathogens was positive) rates of the two groups were 62.5% and 59.4%, which were not significantly different. The prevalence of UU was the highest. The prevalence of UU serotype 14 (Uup14) and MH was associated with hrHPV (P=0.003, P=0.005, respectively), but not with certain hrHPV genotypes or with single or multiple genotypes. Compared with cases of normal+LSIL, cases of HSIL+ICC had significantly different Uup14 infection rates (OR: 12.579, 95% CI: 3.638-43.497, P<0.001) in the positive group. In hrHPV-negative cases, there were obvious differences in Uuu and Uup1 infections based on different cervical lesion types (OR: 11.646, 95% CI: 1.493-90.850, P=0.019; OR: 7.474, 95% CI: 1.140-49.015, P=0.036). Conclusion Asymptomatic STIs in female lower reproductive tract are widespread. Uup14 may increase the risk of HSIL+ICC when hrHPV is positive. Uuu and Uup1 cause an increased risk of HSIL+ICC without hrHPV.
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Objective To investigate the rate of lower reproductive tract infection during pregnancy and the its impact on pregnancy outcome.Methods Five hundred and twenty pregnant women were enrolled in the study who were hospitalized for delivery from Jan.2010 to Jan.2012 at Hebei Port Group Company Limited Harbor hospital.All pregnant women were performed the bacteria detection in vagina before delivery,including candida albicans,bacterial vaginosis,trichomonas,mycoplasma,trachomatis and Neisseria gonorrhoeae,group B hemolytic streptococci GBS.The pregnant outcomes were followed.According to the results of bacteria detection,107 patients (20.58％) were with varying degrees of vaginitis and they were served as positive group.Other 403 patients were served as negative group.Results (1) Of 107 vaginitis women,48 cases (44.86％) were infected with candida albicans,and 22 cases (20.56％) were with bacterial vaginosis.The infection by mycoplasma,chlamydia,group B streptococcal infections were majority,while the trichomonas vaginalis,Neisseria gonorrhoeae infection were minority.(2) Compared with the negative group,incidence of premature rupture of membranes,preterm birth,puerperal infection and fetal distress in positive group were higher and the differences were significant(15.89％ vs.5.08％,12.15％ vs.3.15％,8.41％ vs.1.94％,5.61％ vs.1.21％ ; x2 =14.642,14.498,11.264,7.934; P ＜ 0.01).Conclusion The incidence of genital tract infection is higher during the pregnancy.Bacteria infection detection should be performed and treated as early as possible in order to reduce the occurrence of adverse pregnancy outcome.
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Objective To determine the prevalence and determinants of the most commonly seen lower reproductive tract infections among women aged 25-54 years in Beijing.Methods The study population consisted of 6339 women aged 25-54 years in 137 communities of Beijing.Focus of this study was to understand the prevalence of the following diseases as:bacterial vaginosis,trichomoniasis and vulvovaginal candidiasis.In addition to their prevalence rates,a generalized equation for estimation was used to analyze those infection-associated factors.Results The overall infection prevalence in the lower reproductive tract was 11.4%,including bacterial vaginitis as 8.7%,trichomonads as 1.0% and vulvovaginal candidiasis as 1.7%.Factors which were found to be significantly associated with lower reproductive tract infections in women were age,profession,family income,number of sex partners and frequency of condom use during sexual contacts.In patients with bacterial vaginitis,both prevalence rates of cervical intraepithelial neoplasia and infection of human papillomavirus were high.Conclusion The prevalence of the most commonly seen lower reproductive tract infections among women aged 25-54 years in Beijing was lower than other areas in China.Lower reproductive tract infections seemed to be related to 30-49 years of age,nongovernmental employee,poverty,higher number of sex partners and not using condoms during sexual contacts.