A Retrospective Study of Mean Computed Tomography Value to Predict the Tumor Invasiveness in AAH and Clinical Stage Ia Lung Cancer / 中国肺癌杂志

BACKGROUND@#Recently, the detectable rate of ground-glass opacity (GGO ) was significantly increased, a appropriate diagnosis before clinic treatment tends to be important for patients with GGO lesions. The aim of this study is to validate the ability of the mean computed tomography (m-CT) value to predict tumor invasiveness, and compared with other measurements such as Max CT value, GGO size, solid size of GGO and C/T ratio (consolid/tumor ratio, C/T) to find out the best measurement to predict tumor invasiveness.@*METHODS@#A retrospective study was conducted of 129 patients who recieved lobectomy and were pathological confirmed as atypical adenomatous pyperplasia (AAH) or clinical stage Ia lung cance in our center between January 2012 and December 2013. Of those 129 patients, the number of patients of AAH, AIS, AIS and invasive adenocarcinoma were 43, 26, 17 and 43, respectively. We defined AAH and AIS as noninvasive cancer (NC), MIA and invasive adenocarcinoma were categorized as invasive cancer(IC). We used receiver operating characteristic (ROC) curve analysis to compare the ability to predict tumor invasiveness between m-CT value, consolidation/tumor ratio, tumor size and solid size of tumor. Multiple logistic regression analyses were performed to determine the independent variables for prediction of pathologic more invasive lung cancer.@*RESULTS@#129 patients were enrolled in our study (59 male and 70 female), the patients were a median age of (62.0±8.6) years (range, 44 to 82 years). The two groups were similar in terms of age, sex, differentiation (P>0.05). ROC curve analysis was performed to determine the appropriate cutoff value and area under the cure (AUC). The cutoff value of solid tumor size, tumor size, C/T ratio, m-CT value and Max CT value were 9.4 mm, 15.3 mm, 47.5%, -469.0 HU and -35.0 HU, respectively. The AUC of those variate were 0.89, 0.79, 0.82, 0.90, 0.85, respectively. When compared the clinical and radiologic data between two groups, we found the IC group was strongly associated with a high m-CT value, high Max CT value, high C/T ratio and large tumor size. Gender, solid tumor size, tumor size, C/T ratio, m-CT value and MaxCT value were selected factor for multivariate analysis, when using the preoperatively determined variables to predict the tumor invasiveness, revealed that tumor size, C/T ratio, m-CT value and Max CT value were independent predictive factors of IC.@*CONCLUSIONS@#The musurements of Max CT value, GGO size, solid size of GGO and C/T ratio were significantly correlated with tumor invasiveness, and the evaluation of m-CT value is most useful musurement in predicting more invasive lung cancer.

Associations of manganese superoxide dismutase genetic polymorphism with the susceptibilities of prostate, esophageal and lung cancers: A meta-analysis / 肿瘤

Objective: To evaluate the associations of manganese superoxide dismutase (MnSOD) genetic polymorphism with the susceptibilities of prostate, esophageal and lung cancers. Methods: Studies were identified by searching computerized databases (Cochrane Library, PubMed, etc.), accompanied by manual search. The case-control studies were selected according to defined inclusion and exclusion criteria. After quality evaluation and data abstraction, a meta-analysis was performed by using STATA 11.0 software. Results: A total of 22 case-control studies were eligible for this analysis, including 8 181 cases and 11 844 healthy controls. For prostate cancer, 12 case-control studies included 4 182 cases and 6 885 healthy controls. Meta-analysis showed that MnSOD polymorphism could significantly increase the risk of prostate cancer [heterozygote genotype: odds ratio (OR)=1.11, 95% confidence interval (CI)=1.01-1.22; homozygote genotype: OR=1.25, 95%CI=1.03-1.51); dominant genotype: OR=1.15, 95%CI=1.01-1.31)]. For esophageal cancer, 4 case-control studies contained 620 cases and 909 healthy controls. Meta-analysis showed that MnSOD polymorphism could significantly increase the risk of esophageal cancer [heterozygote genotype: OR=1.58, 95%CI=1.22-2.04; homozygote genotype: OR=2.25, 95%CI=1.61-3.15); recessive genotype: OR=1.69, 95%CI=1.07-2.67); dominant genotype: OR=1.74, 95%CI=1.36-2.22)]. For lung cancer, 6 case-control studies contained 3 375 cases and 4 050 healthy controls. Meta-analysis showed that MnSOD polymorphism could significantly decrease the risk of lung cancer [homozygote genotype: OR=0.68, 95%CI=0.59-0.78); recessive genotype: OR=0.71, 95%CI=0.54-0.93); dominant genotype: OR=0.83, 95%CI=0.75-0.92)]. Conclusion: MnSOD polymorphism is associated with elevated risks of prostate and esophageal cancers, but decreased risk of lung cancer. Copyright© 2011 by Tumor.

Two cases of small cell lung cancer with bony metastases diagnosed with FDG - PET despite a normal planar bone scan / 대한내과학회지

Bone scintigraphy is a very sensitive and cost-effective diagnostic method for detecting bony metastases of malignant neoplasm. However it has been reported that bone scan is less sensitive for early bony metastases, especially vertebral metastases. PET is a non-invasive clinical imaging methodology that can be used to assess such biochemical disturbance in tissue in vivo quantitatively with high resolution.We experienced two cases of small cell lung cancer with multiple bony metastases which were detected on PET imaging but not on planar bone scan. This case report suggests that FDG-PET will be a very effective diagnostic tool for bony metastases especially in clinically suspected case despite a normal planar bone scan.