ABSTRACT
S OBJECTIVE:To study the effect of roxithromycin on cellular immune function and to study its anti-in-flammatory and immunoregulation effects beside its antibacterial effect.METHODS:The mice were randomized into negative control group,roxithromycin(high,medium,low dosage group)groups and dexamethasone group,the splenic lymphocyte conversion ratio of each group was determined by in vivo method and in vitro method respectively after14days of intragastric administration of drugs.RESULTS:Compared with the negative control group,roxithromycin(high,medium,low dosage)groups could significantly reduce splenic lymphocyte conversion ratio of mice(P
ABSTRACT
Objective To study the effect of Zhuang'er Granules(ZG) on cellular immune function of mice.Methods The immunodepression mice models were induced by injection of hydrocortisone.Then the lymphocyte transformation rate was examined by morphological test and phagocyte phagocytosis by in vitro method after 7-day intragastric administration of the drugs.Results Compared with the negative control group,ZG could significantly improve the lymphocyte transformation rate and phagocyte phagocytosis in the normal mice and immunodepression mice(P