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Objective:To explore the impact of cognitive function and childhood trauma in individuals with clinical high risk of psychosis (CHR).Methods:From June 2017 to September 2022, a total of 62 individuals with CHR(CHR group) were screened by structured interviews with psychiatric risk syndrome (SIPS) at Beijing Anding Hospital, and 61 healthy controls(healthy control group) matched in gender, age, and educational years were recruited. All participants were evaluated by the childhood trauma questionnaire (CTQ) and the Chinese version of the MATRICS consensus cognitive test battery (MCCB). Differences in cognitive function and childhood trauma between the two groups were compared by R4.1.1 software, and the correlation between cognitive function and childhood trauma in the CHR group was analyzed.Results:The scores of MCCB composite score (41.46±6.97), information processing speed (40.20±8.40), attention vigilance (40.92±11.00), working memory (41.09±9.97), verbal learning, and visual learning of CHR group were significantly lower than those of healthy controls(MCCB composite score(46.26±7.64), information processing speed(45.83±8.36), attention vigilance(46.30±9.57), working memory(46.18±8.49)), and with statistically significant differences ( t=-3.73--2.03, P<0.05). The total CTQ score, emotional abuse, physical abuse, and physical neglect factor scores of the CHR group (40.0 (36.0, 50.8), 7.5 (6.0, 10.0), 5.0 (5.0, 7.0), 9.0 (7.0, 11.0)) were significantly higher than those of the healthy control group (34.0 (31.0, 40.0), 6.0 (5.0, 8.0), 5.0 (5.0, 6.0), 9.0 (6.0, 10.0) ) ( Z=-4.07--2.06, P<0.05). In the CHR group, the total score of childhood trauma and the score of physical abuse factors were negatively correlated with working memory ( r=-0.29, -0.28, P<0.05), and the total score of cognitive function, attention vigilance, and word learning were negatively correlated with physical neglect ( r=-0.28, -0.26, -0.31, P<0.05). After partial correlation analysis using gender, age, years of education, and total SIPS score as covariates, the aforementioned correlation remained significant. Conclusion:CHR individuals have multiple cognitive deficits, and childhood trauma is more serious. Childhood trauma, especially physical trauma, may affect the cognitive function of CHR individuals.
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ObjectiveTo investigate the psychometric features of MATRICS Consensus Cognitive Battery （MCCB） in adolescents with bipolar disorder， so as to evaluate its appropriateness for the measurement of cognitive deficits in adolescents with bipolar disorder. MethodsAdolescents with bipolar disorder （n=38）， adolescents with major depressive episode （n=40） and healthy controls （n=41） matched on age， sex and educational background were enrolled. Adolescents with bipolar disorder were assessed using Montreal Cognitive Assessment Scale （MoCA） and MCCB at baseline and 2 weeks later， while the rest were only assessed using MCCB at baseline. Thereafter， the psychometric features of MCCB such as internal consistency， test-retest reliability and criterion-related validity， discriminant validity and structural validity were evaluated using Cronbach's α coefficient， Pearson correlation analysis， analysis of covariance and confirmatory factor analysis. Results①The Cronbach's α coefficient of MCCB in adolescents with bipolar disorder was 0.784 at baseline and 0.773 at two weeks later， respectively. ②Among adolescents with bipolar disorder， the test-retest reliability over a two-week interval of each dimension in MCCB ranged from 0.630 to 0.812 （P<0.01）. ③ The criterion-related validity denoted that the score of short-term memory domain in MoCA was positively correlated with the speed of processing， verbal learning and working memory in MCCB （r=0.487， 0.522， P<0.05 or 0.01）. ④ Discriminant validity analysis implied that the scores of the processing speed， attention/vigilance， working memory， verbal learning and memory， visual learning and memory， reasoning and problem solving in MCCB yielded statistical differences among adolescents with bipolar disorder， adolescents with major depressive episode and healthy controls （F=3.790~7.243， P<0.01）. ⑤ Exploratory factor analysis showed that cumulative total variance contribution rate of MCCB amounted to 71.65% of four factors， and the confirmatory factor analysis indicated that the ideal 7-factor model had poor structural validity. ConclusionMCCB has good internal consistency， retest reliability and acceptable validity in adolescents with bipolar disorder.
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Objective To investigate the effect of computerized cognitive remediation therapy (CCRT) on cognitive function in female schizophrenia patients in remission. Methods This study included 42 female schizophrenia patients in remission who were treated at Shenyang Mental Health Center between September 2016 and September 2017. Patients were randomly divided into combined therapy and simple drug treatment groups. Patients in the combined therapy group were treated with oral olanzapine plus CCRT, which was used as cognitive therapy for 12 weeks. Those in the simple drug treatment group only received oral olanzapine for 12 weeks. The MATRICS consensus cognitive battery (MCCB) was used to evaluate cognitive function before treatment and 6 and 12 weeks after treatment. Results At12 weeks after treatment, significant differences were observed in symbol coding, digital sequence, spatial span, semantic fluency, continuous operation, speech memory, visual memory, maze, and total scores in the combined therapy group, while significant differences in symbol coding, semantic fluency, spatial span, speech memory, visual memory, and total scores were observed in the simple drug treatment group (all P ＜ 0.05). The MCCB scores in the combined therapy group were higher than those in the simple drug treatment group at 12 weeks after treatment, with statistically significant differences in continuous operation, digital sequence, speech memory, visual memory, maze, and total scores (P ＜ 0.05). Conclusion CCRT can significantly improve cognitive function in female schizophrenia patients in remission.
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@#【Objective】To explore the characteristics of social cognitive impairment in patients with stable schizophrenia ，and to analyze the influencing factors to provide a clinical coping strategy for improving the social cognitive function of patients with schizophrenia.【Methods】Firstly，both 158 stable schizophrenia patients and 40 healthy controls took the test of MATRICS Consensus Cognitive Battery （MCCB） and the Brief Psychiatric Rating Scale （BPRS）. General demographic information and clinical data of subjects were collected using questionnaire. Then ，the overall cognitive function and social cognitive function between schizophrenia patients and healthy controls were compared to explore the related factors affecting the social cognitive function of patients with schizophrenia.【Results】①Overall MCCB score and Mayer-Salovey-Caruso Emotional Intelligence Test（MSCEIT）factor score of schizophrenia patients with stable period were significantly lower than those of healthy control group（P < 0.05）；②The social cognitive function of schizophrenia patients was significantly correlated with gender，age，hostile suspicion，continuous performance and category fluency （P < 0.05）. 【Conclusions】 Compared with the healthy control group ，schizophrenia patients with stable period have impairment of social cognitive function ，and significant impairment of overall cognitive function. The social cognitive function of schizophrenia patients with stable period is significantly affected by gender ，age ，hostility suspicion ，and neurocognitive function（attention and information processing speed）.
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CONTEXTO: Diversos déficits neuropsicológicos têm sido detectados em indivíduos com risco ultra-alto de desenvolver psicose, mas o melhor instrumento neuropsicológico para detectar esses déficits está ainda para ser determinado. OBJETIVOS: Avaliar o perfil neuropsicológico de indivíduos em risco ultra-alto de psicose (UHRP) usando a bateria MATRICS, em comparação com controles combinados por idade, gênero e quociente de inteligência. MÉTODO: O funcionamento neuropsicológico foi medido em 27 pacientes em UHRP e 38 controles usando a bateria MATRICS. UHRP foi diagnosticado usando a escala para Avaliação Cognitiva de Estados Mentais em Risco (CAARMS), e tanto o funcionamento social como o global também foram avaliados. As comparações entre grupos foram estabelecidas usando ANOVA, ANCOVA e correlação de Pearson. RESULTADOS: Os sujeitos em UHRP marcaram 0,5 a 1,7 desvios-padrão abaixo dos controles na memória de trabalho, aprendizagem verbal e visual e cognição social. CONCLUSÃO: Indivíduos em UHRP apresentam déficits seletivos no funcionamento neurocognitivo quando comparados com controles, que podem ser detectados com MATRICS. Esse instrumento parece ser útil para a detecção temporã de estados de UHRP.
BACKGROUND: Several neuropsychological deficits have been detected in subjects at ultra high risk of developing psychosis, but the best neuropsychological instruments to detect these deficits are yet to be determined. OBJECTIVES: Assess neuropsychological profile of subjects at ultra high risk of psychosis (UHRP) using MATRICS battery (Measurement and Treatment Research to Improve Cognition in Schizophrenia) compared with age, gender and Intelligence Quotient matched controls. METHOD: Neuropsychological functioning was measured in 27 UHRP patients and 38 controls using MATRICS battery. UHRP was diagnosed using the Cognitive Assessment of at Risk Mental States (CAARMS) scale, and both social and global functioning was assessed as well. Comparisons between groups were established using ANOVA, ANCOVA and Pearson correlation. RESULTS: UHRP subjects scored 0.5 to 1.7 SD below controls in working memory, verbal and visual learning and social cognition. DISCUSSION: UHRP subjects exhibit selective deficits in neuro-cognitive functioning when compared with controls, which can be detected with MATRICS. This instrument seems to be helpful for early detection of UHRP states.
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Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Cognition , Schizophrenia/epidemiology , Neuropsychological Tests , Psychotic Disorders/epidemiology , Risk AssessmentABSTRACT
Antipsychotic drugs have focused on treatment of positive and negative symptoms of schizophrenia. While these drugs resulted in improvements of these symptoms, they did not yield the expected recovery to pre-morbid level of functioning. Recently, a growing number of publications have shown that the cognitive deficits are a core feature of schizophrenia and they are critical determinants of poor functional outcome. Measurement And Treatment Research to Improve Cognition in Schizophrenia (MATRICS) is a NIMH initiative that is designed to stimulate development of drugs to improve cognition in schizophrenia. MATRICS has four main goals: 1) to promote development of novel compounds to enhance cognition in schizophrenia, 2) to increase acceptance of cognition in schizophrenia as a valid target for drug approval from the US Food and Drug Administration, 3) to help focus the economic research power of industry on this important, but neglected, clinical target, and 4) to identify promising compounds and support proof of concept trials for cognition-enhancers in schizophrenia. In this article, we reviewed the contents of MATRICS and its progress.