ABSTRACT
Objective To learn therapeutic effect of the combined treatment of mecobalamin and salvia milti-orrhiza ligustrazine on diabetic peripheral neuropathy.To provide effective and reliable operation method for the treat-ment of disease.Methods 163 cases with diabetic peripheral neuropathy were randomly divided into observation group(86 cases)and control group(77 cases).The observation group was treated with mecobalamin combined salvia miltiorrhiza ligustrazine,the control group was treated with mecobalamin.The sensory conduction velocity (SNCV) and motor conduction velocity (MNCV)were measured in the two groups before and after treatment.The therapeutic effects were evaluated after one course.Results The MNCV and SNCV of the two groups were higher than before treatment,the difference was statistically significant (t =24.298,25.546,18.737,15.733,14.284,14.886,9.337, 9.402,all P 0.05).Conclusion In the treatment of diabetic peripheral neuropathy,the com-bined treatment of mecobalamin and salvia miltiorrhiza ligustrazine has better curative effect and low incidence rate of adverse reaction,with good clinical application value.
ABSTRACT
Background: The present study was planned to evaluate the preventive effects of gamma linolenic acid (GLA) on STZ induced diabetic neuropathy Methods: Streptozotocin (STZ) induced diabetic neuropathy in rats was monitored by measuring blood sugar levels, body weight, motor nerve conduction velocity (MNCV) and nociception. Forty rats were divided into 4 groups of 10 each. Group 1: control (vehicle), Group 2: STZ (50 mg/kg, i.v., single injection), Group 3: Gamma linolenic acid (50 mg/ kg, p.o., daily + STZ), Group 4: STZ + Insulin (4 units/kg, s.c., bid). Similar protocol was used for other parameters also. Results: Gamma linolenic acid pretreatment failed to reduce blood sugar levels in diabetic rats but prevented deterioration of motor nerve conduction velocity as compared to STZ diabetic rats. A significant weight gain was observed in STZ diabetic rats pretreated with GLA as compared to rats received STZ alone. Hyperalgesia induced by STZ was antagonized by GLA Conclusions: Thus gamma linolenic acid prevents the development of neuropathic changes induced by STZ in rats.
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Objective:To study the clinical effect of Yang Supplementing Five Returning Decoction(YSFRD) on diabetic peripheral neuropathy. Methods: The curative effect of YSFRD on diabetic peripheral neuropathy and its influence on nerve conduction were comparatively studied. Results: YSFRD was superior to the control group in the curative effect on diabetic peripheral neuropathy ( P
ABSTRACT
Measurement of motor nerve conduction velocity(MNCV) of the median and peroneal nerves was performed in 79 normal fullterm newborn infants and children up through the age of 329 weeks. They were divided into eight groups by age. The following study was undertaken to obtain the mean +/- S.D. and the regression equation of Y (MNCV) on X (age). The MNCV values of each group were compared with those of normal adults.