ABSTRACT
AIM To study the chemical constituents from Magnolia grandiflora L..METHODS The ethyl acetate fracion of 70％ acetone extract from M.grandiflora leaves was isolated and purified by silica,Sephadex LH-20 and MCI column,then the structures of obtained compounds were identified by spectral data.RESULTS Twelve compounds were isolated and identified as 10α-methoxyalloaromadendra-4β-ol (1),spathulenol (2),aromadendra-4β,10β-diol (3),aromadendra-4β,10α-diol (4),9-oxonerolidol (5),9-hydroxynerolidol (6),3,7-dimethylocta-1,5E-diene-3,7-diol (7),phytol (8),α-tocopherol (9),elemicin (10),syringaresinol (11),yangambin (12).CONCLUSION Compounds 1,3-6,8 are isolated from genus Magnolia for the first time,compounds 7,9,10,12 are first isolated from this plant.
ABSTRACT
Objective To study the chemical constituents from the leaves of Magnolia grandiflora. Methods The chemical constituents were isolated and purified by various column chromatographic techniques, including silica gel and Sephadex LH-20, and the structures were identified by spectroscopic analyses. Results Eight sesquiterpenoids were isolated from 70% aq. acetone extract of M. grandiflora and the structures were identified as 12,13-diacetoxy-eudesma-4α,6α,11-triol (1), 12,13-diacetoxy-5αH-guaia-1 (10)-en-4α,6α,11-triol (2), 11,13-dehydrocompressanolide (3), compressanolide (4), α-santonin (5), 1β-hydroxyl-11βH-eudesma-3- en-12,6α-olide (6), β-dictyopterol (7), and 12α-methoxy-germacran-1(10), 4,11(13)-trien-12,6α-acetal (8). Conclusion Compounds 1 and 2 are new compounds named as magnogranol A and B, and compounds 4-8 are isolated from this plant for the first time.