ABSTRACT
Objective To improve the cliniciansˊ awareness of Kluver-bucy syndrome (KBS), we retrospectively analyzed 4 cases of KBS such as clinical manifestation, MRI feature, treatment and prognosis. Methods We performed a retrospective analysis on 4 cases of KBS including general clinical data, key clinical symptoms, findings from cerebrospinal fluid and Cranial MRI examination, treatment strategy and prognosis, and literature review. Results All four patients showed KBS in the course of primary disease. The clinical symptoms of KBS mainly presented as gentle, indiscriminate dietary behavior, hypersexuality, hypermetamorphosis, hyperorality and visual agnosia. MRI Showed primary disease-associated alterations in diverse brain regions including hippocampus, the temporal lobe, the insula, the frontal lobe, and the cingulate gyrus. Three cases achieved completely clinical remission after treatment with carbamazepine,fluoxetine and antipsychotic drugs. One patientˊs symptoms disappeared spontaneously and no recurrence of symptoms was observed in the following 6~12 months. Conclusion Bulimia is often the first symptom of KBS. Cranial MRI is the characteristic of the primary disease and has great diagnostic value. Treatment with antiepileptic and antipsychotics can achieve favorable prognosis.
ABSTRACT
[Objective]To discuss the syndrome differentiation and treatment of classical prescription of ZHANG Zhongjing.[Method]Listing relevant literature and quoting physicians' views on book and combining theory and practice to discuss and distill from the application of thinking methods of syndrome differentiation. [Results] "Treatise on Cold Pathogenic Diseases" fully reflects the syndrome differentiation thoughts, where can be concluded syndrome differentiation and treatment and the method of treatment.Catching the main syndrome means when facing with a specific syndrome can be used to catch the main character of method. And the correspondence between recipe and syndrome is the prescription consistent with the pathogenesis and symptoms of disease which is a prerequisite for syndrome differentiation and treatment.Meanwhile,syndrome differentiation and treatment is a principle of step by step treatment that according to the symptoms and signs of patients,sum up syndrome type,and then prescribe and select drugs at some stage in the disease.And it is also a thinking mode of classical prescription extended application by pathogenesis analysis. Those constitute the three main lines of the thinking method of differentiation.[Conclusion]Accurate differentiation and the prescription are consistented with the syndrome type of"Treatise on Cold Pathogenic Diseases"exert far-reaching influence on the use and perfect syndrome differentiation and treatment,which inspire future generations of doctors.Therefore, it deserves further study. Syndrome differentiation of application thought of classical prescriptions profoundly promotes the development of Chinese traditional medical thinking;the theory has profound significance for clinical practice.