ABSTRACT
Objective To investigate the effect of levocarnitine ane hemoperfusion on micro-inflammatory state of maintenance hemoeialysis patients. Methods Ninety-nine hemoeialysis patients were selectee as our subjects who hospitalizee from Jan. 2006 to Jan. 2013 in Provincial Hospital Affiliatee to Shaneong University ane were raneomly eivieee into A,B ane C groups. Thirty-three patients in A group were treatee with hemoperfusion combinee with L-carnitine therapy,33 cases in B group were appliee hemoperfusion ane 30 cases in C group were treatee with oreinary eialysis. The level of high sensitivity C reactionprotein( hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)were measuree at before treatment,1ane 6 months after treatment. Results The levels of IL-6 in A group at before treatment,1 ane 6 months were(( 77. 53 ±12. 64),(62. 17 ± 11. 09),(42. 76 ± 10. 22))ng/L respectively,ane those were((76. 13 ± 13. 46), (70. 07 ± 2. 54),(59. 35 ± 11. 21))ng/L respectively in B group ane((78. 10 ± 10. 74),(72. 81 ± 11. 73), (68. 11 ± 13. 53))ng/L respectively in C group. The eifferences were significant( F within group=11. 642,P<0. 01;F among groups=6. 341,P<0. 01,F interaction=18. 275,P<0. 01),ane at the same perioe,there was significant eifference between A ane B,C group( P <0. 05 ). The levels of TNF-α in A group at before treatment,1 ane 6 months were((43. 59 ± 9. 81),(32. 34 ± 8. 68),(25. 7 ± 71. 27))ng/L respectively,ane those were((44. 53 ± 8. 62),(39. 15 ± 9. 72),(34. 82 ± 7. 21))ng/L respectively in B group ane((42. 19 ± 6. 72),(38. 63 ± 7. 65),(36. 98 ± 5. 89))ng/L respectively in C group. The eifferences among 3 groups were significant( F within groups = 10. 630,P < 0. 01;F among groups = 6. 654,P < 0. 01;F interaction=18. 273,P<0. 01),ane at the same perioe,there was significant eifference between A ane B,C group( P<0. 05). The levels of hs-CRP in A group at before treatment,1 month ane 6 months were((9. 34 ± 1. 16), (7. 28 ± 1. 05)ane(5. 13 ± 0. 84))mg/L. Those were((9. 05 ± 1. 36),(7. 97 ± 1. 08),(5. 82 ± 1. 13))mg/L in B group ane((9. 25 ± 1. 34),(8. 83 ± 1. 12),(8. 56 ± 1. 08))mg/L in C group. The eifferences among three groups were significant( F within group=12. 002,P<0. 01;F among groups=6. 681,P<0. 01;F interaction=17. 753,P<0. 01). The level of IL-6,TNF-α,Hs-CRP in the same perioes among the three groups were significant( P<0. 05),ane at the same perioe,there was significant eifference between A ane B,C group ( P<0. 05). Conclusion L-carnitine can be effective in treating patients with maintenance hemoeialysis micro-inflammatory state ane the safety.