ABSTRACT
Objective To assess the diagnostic performance of Mainz ultrasound scoring system combined with 3D-power Doppler ultrasound(PDU) and CA125 in differentiating benign and malignant pelvic tumors.Methods The randomly selected patients were divided into two groups according to the pathological results,the benign group ( n =61) and malignant group ( n =79).Mainz scoring system was used to evaluate the tumor score of 150 pelvic masses,3D-PDU scan was performed to obtain vascular index (VI),blood flow index (FI),and vascular flow index (VFI) by two doctors with more than 5 years working experience in double-blind.The VI,FI,VFI and serum markers of two groups were compared to evaluate the value of Mainz scoring system and in combination with 3D-PDU and CA125 in the differential diagnosis of benign and malignant tumors. Results Compared with benign group,VI,FI and VFI increased significantly in malignant group(all P < 0.01). The Kappa indices of using Mainz ultrasound scoring system and using Mainz ultrasonic scoring system combined with 3D-PDU to distinguish benign and malignant pelvic masses were 0.79 and 0.83,respectively.The sensitivity,specificity and accuracy of Mainz score to evaluate benign and malignant pelvic tumors were 85.1%,78.2% and 82.0%,respectively,the sensitivity,specificity and accuracy were 89.2%,86.3% and 88.0% when combined with 3D-PDU. As compared with 3D-PDU and serum markers,the sensitivity was 96.4%,specificity was 90.9% and accuracy was 94.0%,respectively. Conclusions Mainz ultrasound scoring system has important clinical value in distinguishing benign and malignant pelvic masses,when combined with 3D-PDU its sensitivity,specificity can be improved significantly.The sensitivity and specificity are further improved after combining of clinical serological markers.