ABSTRACT
ABSTRACT: Tumors affecting Bartholin's gland are considered rare in human medicine; there are few reports in the veterinary literature, with descriptions occurring only in cows. This article described the clinical and pathological findings associated with Bartholin's gland adenoma in a goat. Clinically, a 7-year-old pregnant Saanen goat presented bilateral enlargement of the vulva that did not regress spontaneously after parturition. Grossly, these vulvar masses were multilobulated, contained cystic areas from which oozed a whitish fluid. Histopathology revealed an adenoma characterized by the proliferation of irregularly shaped neoplastic epithelial cells that formed tubular to glandular-like structures. These neoplastic cells demonstrated moderate anisokaryosis and evident nucleoli. The intratumoral proliferation index (PI) was estimated by immunoreactivity with the protein ki-67. Further, the glandular-like structures produced a Periodic Acid-Schiff positive secretion. A diagnosis of Bartholin's gland adenoma was established due to the anatomic location of the neoplastic growths, the histopathological features, and the PI of the tumor.
RESUMO: Tumores que afetam a glândula de Bartholin são considerados raros em humanos e há poucos relatos na medicina veterinária, sendo descrito somente em vacas. Este artigo descreve os achados clínicos e patológicos associados ao adenoma na glândula de Bartholin em uma cabra. O animal da raça Saanen, com sete anos de idade e gestante apresentava aumento de volume bilateral na região da vulva, que não regrediu após o parto. Macroscopicamente, a massa era multilobulada, com presença de vários cistos preenchidos por uma secreção esbranquiçada. A histopatologia revelou um adenoma, caracterizado por proliferação de células epiteliais de formato irregular que formavam estruturas tubulares semelhantes à glândulas. Estas células neoplásicas apresentavam anisocariose moderada e nucléolos evidentes. O índice de proliferação celular intratumoral (PI) foi estimado por imunorreatividade à proteína ki-67. Além disso, a secreção produzida por essas estruturas do tipo glandular, foi positiva na coloração do Ácido Periódico-Schiff. O diagnóstico de adenoma da glândula de Bartholin foi estabelecido pela localização anatômica dos tumores neoplásicos, características histopatológicas e à PI do tumor.
ABSTRACT
Los quistes de la glándula de Bartholin son problemas comunes en mujeres en edad reproductiva. Los abscesos son tres veces más comunes que los quistes. En general, los quistes de las glándulas de Bartholin alcanzan diámetros de 1 a 4 cm, y suelen ser asintomáticos. Se reporta de una paciente femenina de 27 años de edad, con quiste gigante, que mide 11 x 9 x 5,6 cm. Presenta aumento de volumen de región vulvovaginal, molestias durante el coito, acompañado de dolor ligero. Fue operada en el Hospital General Docente "Héroes del Baire", Nueva Gerona, Isla de la Juventud donde presentó una complicación posquirúrgica inmediata, hematoma del sitio operatorio, pero finalmente, su evolución fue satisfactoria. La motivación del presente reporte es por lo infrecuente de su aparición y la existencia en Cuba de pocos reportes. El papel que desempeña la atención primaria de salud y lo común de esta enfermedad hace que se le reste valor e importancia; sin embargo, el necesario ejercicio de diagnóstico diferencial de esta enfermedad enfatiza la importancia de este reporte de caso(AU)
Bartholin's cysts are common problems in women at reproductive age. Abscesses are three times more common than cysts. Most Bartholin's cysts reach a diameter from 1 to 4 cm, and are usually asymptomatic. A 27-year-old female patient is reported with a giant cyst measuring 11 x 9 x 5.6 cm. She is presented with volume increase in the vulvovaginal region, discomfort during intercourse, accompanied by mild pain. She was operated at Heroes del Baire General Teaching Hospital in Nueva Gerona, Isla de la Juventud, where she presented an immediate postoperative complication, a hematoma to the operative site, but finally she has a satisfactory evolution. The motivation for this report is its infrequent onset and the existence in Cuba of a few reports only. The role of primary health care and the common onset of this disease make it lose value and importance; however, the necessary practice of differential diagnosis for this disease emphasizes the importance of this case report(AU)