ABSTRACT
With the younger onset of diabetes, the reproductive dysfunction caused by diabetes has received widespread attention. Hyperglycemia and insulin resistance, the main features of diabetes, are high-risk factors for male reproductive dysfunction. Obesity, the common co-morbidity of diabetes, may aggravate the progression of reproductive dysfunction. Glucagon-like peptide-1(GLP-1) and its receptor agonists improve the overall health status by lowering blood glucose, reducing body weight, and inhibiting inflammatory response, which indirectly exerts protective effects on the reproductive system. GLP-1 also protects reproductive function by regulating the neuroendocrine function, and directly acting on the supporting cells and interstitial cells of the testis. However, some studies did not find the protective effects. High-quality clinical studies are needed. GLP-1 receptor agonists may be a therapeutic option to improve reproductive dysfunction in diabetic men.
ABSTRACT
The epidemiology of inguinal hernia,the mesh's side effects on the spermatic cord,the spermatic cord blood vessels,the was deferens and the testicular in inguinal hernia hemiorrhaphy of tension-free were reviewed.The effects of the inguinal hernia herniorrhaphy and the mesh in clinical and animal experiments which affected on the male reproductive function such as the location.extent and pathological changeswere summarized,and the mechanism of the tension-free inguinal herniorrhaphy affecting the male reproducrive function were discussed.Improvingthe operation skills and the more appropriate choice of the mesh may protect the male reproductive function in tension-free inguinal hernia hemiorrhaphy.