ABSTRACT
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ABSTRACT
Malignant transformation of hidroacanthoma simplex into in situ porocarcinoma, also known as hidroacanthoma simplex with invasive growth, is very rare. Malignant hidroacanthoma simplex generally arises in the elderly and occurs most frequently on the lower extremities and trunk. The gross appearance of the tumor tends to vary, and there are nodular lesions or keratotic plaques with or without erosion and/or ulceration. In some cases, it clinically resembles Bowen's disease or seborrheic keratosis. Histopathologically, the tumor appears similar to hidroacanthoma simplex, but the cells are atypical with hyperchromatic nuclei, and many are in mitosis. Here we report an extremely rare case of malignant hidroacanthoma simplex that occurred on the right knee of an 84-year-old Korean woman.
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Bowen's Disease , Keratosis, Seborrheic , Knee , Lower Extremity , Mitosis , UlcerABSTRACT
PURPOSE: Hidroacanthoma simplex (HAS) is a rare benign neoplasm of the skin and known as intraepidermal poroma. Malignant transformation of HAS has been reported in the literature, but it is very rare. We experienced a case of malignant hidroacanthoma simplex (MHA) and performed the surgery of the neoplasm. METHODS: A 73-year-old patient visited our department for evaluation and treatment of the skin lesion (3.2 x 3.0 cm2) that occurred two years before on the right ankle area. The lesion was characterized by dark-brown, hyperkeratotic and protruding patch. The patient had no symptom, and any palpable lymph node was not found on physical examination. The result of laboratory was also nonspecific. The lesion was excised completely with a resection margin of 5 mm including subcutaneous tissue partially, followed by full-thickness skin graft for reconstruction. RESULTS: The result of biopsy was reported as malignant hidroacanthoma simplex. Histologically, the epidermis showed discrete aggregates of tumor cells which had round, hyperchromatic nuclei and pale or clear abundant cytoplasm. Cystic spaces were found within the tumor and mitosis were seen, frequently. No recurrence was found one month after surgery. CONCLUSION: The case of malignant hidroacanthoma simplex was treated with full-thickness skin graft following wide excision of the tumor.
Subject(s)
Aged , Animals , Humans , Ankle , Biopsy , Cytoplasm , Epidermis , Lymph Nodes , Methylmethacrylates , Mitosis , Physical Examination , Polystyrenes , Poroma , Recurrence , Skin , Subcutaneous Tissue , TransplantsABSTRACT
PURPOSE: Hidroacanthoma simplex (HAS) is a rare benign neoplasm of the skin and known as intraepidermal poroma. Malignant transformation of HAS has been reported in the literature, but it is very rare. We experienced a case of malignant hidroacanthoma simplex (MHA) and performed the surgery of the neoplasm. METHODS: A 73-year-old patient visited our department for evaluation and treatment of the skin lesion (3.2 x 3.0 cm2) that occurred two years before on the right ankle area. The lesion was characterized by dark-brown, hyperkeratotic and protruding patch. The patient had no symptom, and any palpable lymph node was not found on physical examination. The result of laboratory was also nonspecific. The lesion was excised completely with a resection margin of 5 mm including subcutaneous tissue partially, followed by full-thickness skin graft for reconstruction. RESULTS: The result of biopsy was reported as malignant hidroacanthoma simplex. Histologically, the epidermis showed discrete aggregates of tumor cells which had round, hyperchromatic nuclei and pale or clear abundant cytoplasm. Cystic spaces were found within the tumor and mitosis were seen, frequently. No recurrence was found one month after surgery. CONCLUSION: The case of malignant hidroacanthoma simplex was treated with full-thickness skin graft following wide excision of the tumor.
Subject(s)
Aged , Animals , Humans , Ankle , Biopsy , Cytoplasm , Epidermis , Lymph Nodes , Methylmethacrylates , Mitosis , Physical Examination , Polystyrenes , Poroma , Recurrence , Skin , Subcutaneous Tissue , TransplantsABSTRACT
Hidroacanthoma simplex is a benign tumor believed to arise from the uppermost segment of the intradermal eccrine duct and the acrosyringium, and histologically shows intraepidermal focal growth. A malignant counterpart to this tumor is rare and named malignant hidroacanthoma simplex or porocarcinoma in situ. We report a case of atypical hidroacanthoma simplex, which is considered to be a malignant transformation of benign hidroacanthoma simplex in a 83- year-old female.