Mesenquimoma pélvico maligno. Informe de caso

Se presentó un enfermo de 73 años en el Hospital Clínico Quirúrgico Docente "Amalia Simoni" de la ciudad de Camagüey, Cuba, que fue intervenido quirúrgicamente hace cinco años y cuyo resultado fue desconocido. En aquel entonces presentó dolor y limitación funcional del miembro inferior derecho, lo que motivó la resección de un tumor en el fémur ipsilateral; cinco años después recidiva, esta vez con invasión de la pelvis ósea y del recto, evidenciándose trastornos miccionales y constipación. La radiografía de pelvis ósea, tomografía computarizada y resonancia magnética de dicha región evidenciaron una imagen tumoral mixta con lesiones líticas que invadió y desplazó los órganos de la cavidad pélvica. El paciente fue sometido a exéresis del tumor, el cual fue de 173×156 mm, con un peso de aproximadamente 1 380 g. El análisis histopatológico de la pieza quirúrgica evidenció un mesenquimoma pélvico maligno.

It was reported a case of a 73 years old patient with a history of an unknown outcomes surgical procedure 5 years ago at the Hospital Clínico Quirúrgico Docente "Amalia Simoni" in Camaguey, Cuba. He presented pain and functional limitation of the right lower limb, which led to the resection of a tumor in the ipsilateral femur; five years later the tumor present signs of recurrence, this time with invasion of the bony pelvis and rectum and resulting in urinary disorders and constipation. Pelvis bone radiology, computed tomography scan and magnetic resonance imaging of the pelvis showed a mixed tumor with lytic lesions that invaded and displaced the organs in the pelvic cavity. The patient underwent excision of the tumor, which was 173×156 mm, weighing approximately 1.380 g. Histopathological analysis of the surgical resection specimen revealed a pelvic malignant mesenchymoma.

Apresentou-se um paciente de 73 anos, operado há 5 anos no Hospital Provincial Amalia Simoni, na cidade de Camagüey, Cuba, cujo resultado era desconhecido. Na época, apresentava dor e limitação funcional do membro inferior direito, o que levou à ressecção de tumoração no fêmur ipsilateral; cinco anos depois, recidiva, desta vez com invasão de pelve óssea e reto, evidenciando distúrbios miccionais e constipação. A radiografia óssea da pelve, a tomografia computadorizada e a ressonância magnética da referida região revelaram uma imagem tumoral mista com lesões líticas que invadiam e deslocavam os órgãos da cavidade pélvica. A paciente foi submetida à exérese do tumor, que media 173×156 mm, com peso aproximado de 1380 g. A análise histopatológica da peça cirúrgica revelou um mesenquimoma pélvico maligno.

Malignant mesenchymoma of vulvar in youth:A case report and literature review / 实用肿瘤学杂志

Malignant mesenchymoma is composed by two or more unrelated mesenchymal elements ,it is rare in clinic.Both domestic and abroad have few case reports ,it tends to occur in older people and the incidence of mesenchymoma is higher in males than in females .The malignant tumor in young female genital is more rare . Malignant mesenchymoma often appears in limbs ,it is difficult to be diagnosed before surgical operation .It is con-firmed by pathological examination .The degree of this malignant is higher and the recurrence rate is high .There is no specificity in clinic .The imaging characteristics are so less that it can not be taken seriously .We report a case of malignant mesenchymoma in vulva which is confirmed by pathology .

Retroperitoneal Malignant Mesenchymoma: A Case of Mesenchymal Mixed Tumor with Osteosarcoma, Leiomyosarcoma, Liposarcoma and Fibrosarcoma

Malignant mesenchymoma is an interesting but very rare tumor in which malignant differentiation has occurred twice or more. We report a case of retroperitoneal malignant mesenchymoma consisting of osteosarcoma, leiomyosarcoma, liposarcoma and fibrosarcoma. Abdominal CT showed a large retroperitoneal mass with two separate and distinct parts, namely an area of prominent calcification and one of clearly enhancing solid components. The mass contained histologically distinct tumorous components with no histologic admixure at the interfaces. The densely calcified nodule corresponded to osteosarcoma, and the noncalcified clearly enhancing nodules to leiomyosarcoma, liposarcoma and fibrosarcoma.

A Case of Malignant Mesenchymoma of the Heart

Malignant mesenchymomas by definition are composed of two or more cellular types that would ordinarily derive from primitive mesenchyme. They grow rapidly, recur frequently, metastasize, and can be found in a wide variety of locations. Malignant mesenchymomas as primary cardiac tumor are extremely rare with poor prognosis. Only 15 cases of cardiac malignant mesenchymoma were reported in worldwide literature in 1961-1992. We report a case of primary cardiac malignant mesenchymoma in 58 year-old female patient admitted due to hemoptysis and mild exertional dyspnea.

Primary Sarcomas of the Liver

Primary hepatic sarcomas are uncommon, representing less than 1% of the primary malignant lesions of the liver. Three patients underwent resection for primary hepatic sarcoma at the Department of Surgery, Inje University Paik Hospital, Seoul: a 6 year-old girl with malignant mesenchmoma, a 74 year-old man with malignant fibrous histiocytoma and a 53 year-old man with rhabdomyosarcoma. Abdominal mass, fever with chills, and abdominal pain were the presenting symptoms, respectively. The patient with rhabdomyosarcoma was positive for HBsAg and had chronic active hepatitis. AFP level was elevated in this patient. CA 19-9 level was elevated in the patient with malignant fibrous histiocytoma. CEA levels were normal in all cases. All these tumors were hypodense on computed tomography. Malignant mesenchymoma was hypovascular and rhabdomyosarcoma was hypervascular on angiography. Immunohistochemical stains of the tumors were positive for vimentin but negative for epithelial markers, differentiating these lesions from other hepatic tumors. Electron microscopic examination was helpful in the diagnosis of the specific type of primary hepatic sarcoma. None had postoperative adjuvant chemotherapy or radiotherapy. The patient with malignant mesenchymoma, who underwent right hepatic trisegmentectomy, was disease free at 32 months. The patient with malignant fibrous histiocytoma, who underwent non-curative excision, died of the tumor at 2 months. The patient with rhabdomyosarcoma, who underwent posterior segmentectomy, was alive at 4 months. Resection of primary hepatic sarcoma should be executed if feasible, with potential survival measured in years, in view of the lack of other effective treatment modalities.

A Case of Malignant Mesenchymoma in Inguinal Region / 대한비뇨기과학회지

Malignant mesenchymoma is a rare soft tissue neoplasm showing two or more separate and distinct types of malignant mesenchymal differentiation in addition to an undifferentiated sarcomatous component. Occasional cases of malignant mesenchymoma have been reported in the spermatic cord and paratesticular area. However, documented reports have been seldom found in Korea. We report a case in which there was evidence of lipo-, rhabdomyo-, osteosarcomatous differentiation in the same neoplasm with brief review of the literatures.