Drug-induced Sleep Endoscopy: Are there Predictors for Failure of Oral Appliance Treatment?

Abstract Introduction In the literature, evidence is lacking on the predictive value of druginduced sleep endoscopy (DISE) for oral appliance treatment (OAT). Objectives The aim of the present study is to evaluate whether DISE with concomitant mandibular advancement maneuver can predict failure of OAT. Methods An observational retrospective study including patients diagnosed with obstructive sleep apnea (OSA) who previously received OAT. Results of DISE were analyzed in a group with documented OAT failure (apnea-hypopnea index [AHI] >10 events/hour or < 50% reduction) and a group with OAT benefit (AHI <10 events/hour or >50% reduction). The upper airway was assessed using the velum, oropharynx, tongue base, epiglottis (VOTE) classification. Additionally, a mandibular advancement maneuver, manually protruding the mandible by performing a jaw thrust, was performed to mimic the effect of OAT. Results The present study included 50 patients with OAT failure and 20 patients with OAT benefit. A subgroup analysis of patients with OAT failure and an AHI <30events/hour included 26 patients. In the OAT failure group, 74% had a negative jaw thrust maneuver. In the subgroup with an AHI <30 events/hour, 76.9% had a negative jaw thrust maneuver. In the OAT benefit group, 25% had a negative jaw thrust maneuver (p< 0.001). Conclusions A negative jaw thrust maneuver during DISE can be a valuable predictor for OAT failure, independent of AHI. Drug-induced sleep endoscopy should be considered as a diagnostic evaluation tool before starting OAT.

Repercusiones del uso de Dispositivos de Avance Mandibular como Terapia para el Síndrome de Apnea Obstructiva del Sueño en el Complejo Temporomandibular. Revisión Narrativa / Repercussions of the use of Mandibular Advancement Devices as Therapy for Obstructive Sleep Apnea Syndrome in the Temporomandibular Complex. Narrative Review

RESUMEN: El objetivo de este trabajo fue escribir, según la literatura científica disponible más actual, los efectos que inducen el uso de dispositivos de avance mandibular, como terapia para el SAHOS, en el sistema temporomandibular de los pacientes. Se realizó una revisión de la literatura más actual (últimos 10 años; 2006-2016) a partir de la búsqueda electrónica en las bases de datos PubMed, TripData Base, Epistemonikos, The Cochrane Library y las revistas especializadas Journal of Clinical Sleep Medicine y SLEEP. Con el uso de las palabras clave: "Mandibular advancement device", "orthodonthic appliances", "sleep apnea syndroms", "sleep apnea obstructive", "Temporomandibular joints disorder", los operadores booleanos AND y OR. Se realizó un análisis crítico de la literatura evaluando nivel de evidencia, grado de recomendación y riesgo de sesgo de cada publicación. La búsqueda en las distintas bases de datos arrojó un total de 242 documentos, de los cuales 60 fueron seleccionados por título y abstract. Luego 8 estudios fueron descartados por estar repetidos. Se aplicaron los criterios de inclusión y exclusión quedando un total de 20 artículos; se eliminaron 8 por no responder a la pregunta de investigación y se añadió 1 título mediante la búsqueda manual. Finalmente, se analizaron 13 artículos; 2 revisiones sistemáticas, 2 ensayos clínicos aleatorizados y 6 series de casos. La mayoría de los documentos incluidos concuerda en que los efectos inducidos por los DAM, sobre el complejo temporomandibular son mínimos y reversibles, sin explicitar ningún diagnóstico de TTM en particular. Sin embargo, esta evidencia viene en su mayoría de estudios recomendables, pero no concluyentes. Se necesitan más y mejores estudios para realizar un análisis y abstraer conclusiones más certeras. Estos deben ser homogéneos a la hora de clasificar TTM y definir un protocolo óptimo de avance mandibular.

ABSTRACT: The aim of this study was to describe, based on the most recent scientific literature available, the effects produced by the mandibular advance appliances (MAA) as a therapy for obstructive sleep apnea-hypopnea syndrome (OSAHS) in the temporomandibular system. We carried out a review of the most current literature published in the last 10 years, based on an electronic search in PubMed, TripData Base, Epistemonikos, The Cochrane Library and the specialized magazines Journal of Clinical Sleep Medicine and SLEEP. The key words used for each search were "MANDIBULAR ADVANCEMENT DEVICE", "ORTHODONTIC APPLIANCES", "SLEEP APNEA SYNDROMS", "SLEEP APNEA, OBSTRUCTIVE", and "TEMPOROMANDIBULAR JOINT DISORDERS" combined with boolean operators AND and OR. A critical analysis of the literature was evaluated based on the level of evidence, degree of recommendation and risk of bias of each publication. We obtained 242 articles and 60 of these were selected by title and abstract. Inclusion and exclusion criteria were applied, obtaining 20 articles of which 8 were excluded because they did not answer the investigation question. One article was obtained by manual search. Of this number, 13 articles, 2 systematic reviews, 2 randomized clinical trial and 6 cases series were analyzed. Most of the articles analyzed agreed that the effects produced by the MAA in the temporomandibular complex are minimal and reversible, and they did not specify any TMD diagnosis in particular. However, this evidence comes mostly from recommended but inconclusive studies. More and better designed studies are needed, with homogeneous classification of TMD diagnostic criteria that allows to define an optimal protocol for mandibular advancement as a therapy.

Effect of mandibular advancement device upon nuclear factor κB and tumor necrosis factor α, interleukin 6 in genioglossus of rabbit with obstructive sleep apnea hypopnea syndrome / 中华口腔医学杂志

Objective@#To investigate the effects of mandibular advancement device (MAD) upon nuclear factor κB (NF-κB), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in the genioglossus.@*Methods@#Eighteen New Zealand white rabbits (male, six months old), in accordance with the random number table, were equally divided into three groups, the control group, obstructive sleep apnea hypopnea syndrome (OSAHS) group and MAD group. All animals were induced to sleep in supine position for 2 hours every morning in the next 8 weeks. The specimens of genioglossus were prepared. The relative expression of NF-κB p65 was measured with Western blotting and the mass concentration of TNF-α and IL-6 was determined with enzyme-linked immunosorbent assay.@*Results@#The relative expressions of NF-κB p65 protein in genioglossus in the control group, OSAHS group and MAD group were 0.24±0.07, 0.44±0.08 and 0.30±0.09, respectively. The mass concentrations of TNF-α in genioglossus in the control group, OSAHS group and MAD group were (0.065±0.020), (0.097±0.018) and (0.071±0.020) μg/L, respectively. The mass concentrations of IL-6 in genioglossus in the control group, OSAHS group and MAD group were (0.063±0.013), (0.093±0.017), and (0.069±0.014) μg/L, respectively. For the above indicators, the data in OSAHS group were all significantly higher than that in MAD group and the control group (P<0.05). No significant difference was found between MAD group and the control group (P>0.05).@*Conclusions@#Treatment of OSAHS with MAD decreased the mass concentration of TNF-α and IL-6 leading to fatigue of genioglossus, reduced the activation of NF-κB and played a significant role in protecting genioglossus.

Analysis of Long-Term Complication on Patients with Obstructive Sleep Apnea Who Treated Mandibular Advancement Device / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Recently, mandibular advancement device (MAD) has been used widely used for the treatment of obstructive sleep apnea (OSA) because it can effectively reduce the collapsibility of upper airway during sleep. Although MAD is widely prescribed by otorhinolaryngologists, several studies described its complications arising from the anterior placement of the mandible with long-term use. However, there is still a lack of studies on long-term complications in Korean patients. SUBJECTS AND METHOD: Retrospectively, we included a total of 57 OSA patients in the study. In this study, all enrolled OSA patients had used MAD over two years with more than 4 hours/day. Dental consulting and cephalometric analysis were conducted to identify the change of dental and skeletal findings at two different times (baseline and after 2 year). RESULTS: The dental findings showed that the overbite and overjet were significantly decreased. Additionally, the proclination of the lower incisors were increased significantly, whereas there was no significant change on the retroclination of the upper incisors. Three patients showed a change of malocclusion type. On the analysis of skeletal findings, we found a significant increase in the sella turcica central point-nasion-supramental point angle and a decrease in the subspinal point-nasion-supramental point angle. Moreover, the anterior lower facial height and anterior facial height were significant increased. CONCLUSION: Consistent with Western studies, our findings suggest that the long-term use of MAD could induce changes in dental and skeletal morphologies in Korean OSA patients. Therefore, clinicians should thoroughly evaluate potential changes in dental and skeletal morphologies when they prescribe MAD to patients with OSA.

Therapeutic efficacy of a hybrid mandibular advancement device in the management of obstructive sleep apnea assessed with acoustic reflection technique.

Obstructive sleep apnea (OSA) is one of the most common forms of sleep‑disordered breathing. Various treatment modalities include behavior modification therapy, nasal continuous positive airway pressure (CPAP), oral appliance therapy, and various surgical modalities. Oral appliances are noninvasive and recommended treatment modality for snoring, mild to moderate OSA cases and severe OSA cases when patient is not compliant to CPAP therapy and unwilling for surgery. Acoustic reflection technique (ART) is a relatively new modality for three‑dimensional assessment of airway caliber in various clinical situations. The accuracy and reproducibility of acoustic rhinometry and acoustic pharyngometry assessment are comparable to computerized tomography and magnetic resonance imaging. This case report highlights the therapeutic efficacy of an innovative customized acrylic hybrid mandibular advancement device in the management of polysomnography diagnosed OSA cases, and the treatment results were assessed by ART.

Dental Considerations For Upper Airway Sleep Disorder Patients.

Sleep disorders are becoming a common medical problem. Multiple treatment options have been advocated including the use of dental devices. Dental practitioners becoming a part of the treatment team is again a problem because of the wide variety of dental devices available and the rapid advancement in the understanding of the disease. This article reviews the anatomy, physiology, etiopathogenesis of obstructive sleep apnea (OSA) and various medical and dental treatment options.

Assessment of Treatment Outcome after Using Temporary Mandibular Advancement Devices in Obstructive Sleep Apnea Patients

50% Apnea-Hypopnea Index (AHI) reduction plus post-MAD AHI <10, and the non-response group was defined as <50% AHI reduction. The lateral cephalogram was analysed including SNA, SNB, UL, MPH, PAS, PASU, and PAST using V-ceph(TM) (Cybermed, USA).RESULTS: The responsers were 23 patients, and non-responsers were 5 patients. The AHI was significantly reduced with temporary MAD (8.08+/-7.93) compared with baseline (28.51+/-20.56) in the response group (n=23). No significant difference was observed between pre MAD and post MAD except SNB on cephalometric analysis. Among 11 patients successfully treated with the temporary device, 9 patients said that using permanent device brings better effect too.CONCLUSION: These results indicate that the Temporary MAD could not be the only effective tools on OSA but also be used to predict patient's reactivity about permanent appliance treatment. Further studies are warranted to evaluate the relations between temporary MAD and permanent MAD.

The Influence of the Amount of Mandibular Advancement in the Application of Mandibular Advancement Device for Obstructive Sleep Apnea Patients / 수면정신생리

OBJECTIVES: The purposes of this study were to estimate the effect of mandibular advancement device (MAD) and to evaluate the influence of the advancement amount of mandible in the application of MAD for obstructive sleep apnea (OSA) patients. METHODS: From the patients who were diagnosed as OSA by polysomnographic study at Seoul National University Bundang Hospital from January 2007 to February 2009, the patients who chose MAD as treatment option were included in this study. All the patients' data including clinical records and polysomnographic studies (both pre- and post-treatment) were reviewed and analyzed. RESULTS: Successful results were obtained in 65 patients of 86 patients (75.6%). In the follow-up period, mild discomfort of anterior teeth or temporomandibular joint (TMJ) were described in 28 patients, especially in the cases the amount of mandibular advancement were more than 7.0 mm. There was no direct relationship between the amount of mandibular advancement and clinical outcome. CONCLUSION: MAD was effective treatment option for the OSA patients regardless of severity. For the prevention of potential dental complications, the amount of mandibular advancement should be considered at the time of MAD treatment.

Aparelho de avanço mandibular aumenta o volume da via aérea superior de pacientes com apneia do sono / Increase in upper airway volume in patients with obstructive sleep apnea using a mandibular advancement device

INTRODUÇÃO: o diagnóstico, o tratamento e o acompanhamento de pacientes portadores da síndrome da apneia obstrutiva do sono (SAOS) são essenciais, por se tratar de um distúrbio que pode causar alterações sistêmicas. A efetividade do tratamento da SAOS com aparelhos intrabucais foi demonstrada através de estudos cefalométricos. OBJETIVO: o objetivo deste estudo foi avaliar o efeito do aparelho de avanço mandibular (Twin Block, TB) no volume das vias aéreas superiores, por meio de tomografia computadorizada Cone-Beam (CBCT). Dezesseis pacientes (6 homens e 10 mulheres) portadores de SAOS leve a moderada, idade média de 47,06 anos, utilizaram um aparelho de avanço mandibular e foram acompanhados por 7 meses, em média. MÉTODOS: foram feitas duas CBCT, sendo uma sem e outra com o aparelho em posição. A segmentação e a obtenção dos volumes das vias aéreas superiores foram realizadas e utilizado o teste t de Student pareado para análise estatística, com 5 por cento de significância. RESULTADOS: houve aumento do volume da via aérea superior com TB quando comparado com o volume sem TB (p<0,05). CONCLUSÃO: pode-se concluir que o aumento de volume da via aérea superior observado foi associado ao aparelho de avanço mandibular.

INTRODUCTION: Diagnosis, treatment and monitoring of patients with obstructive sleep apnea syndrome (OSAS) are crucial because this disorder can cause systemic changes. The effectiveness of OSAS treatment with intraoral devices has been demonstrated through cephalometric studies. OBJECTIVE: The purpose of this study was to evaluate the effect of a mandibular advancement device (Twin Block, TB) on the volume of the upper airways by means of Cone-Beam Computed Tomography (CBCT). Sixteen patients (6 men and 10 women) with mild to moderate OSAS, mean age 47.06 years, wore a mandibular advancement device and were followed up for seven months on average. METHODS: Two CBCT scans were obtained: one with and one without the device in place. Upper airway volumes were segmented and obtained using Student's paired t-tests for statistical analysis with 5 percent significance level. RESULTS: TB use increased the volume of the upper airways when compared with the volume attained without TB (p<0.05). CONCLUSION: It can be concluded that this increased upper airway volume is associated with the use of the TB mandibular advancement device.

Treatment of OSAHS with the mandibular advancement devices / 实用口腔医学杂志

The obstructive sleep apnoea/hypopnoea syndrome (OSAHS) affects approximately 2%-4% of the middle-aged population. It is characterized by obstruction of the upper airway during sleep, resulting in repetitive breathing pauses accompanied by oxygen desaturation. It has been recognized as an independent risk factor for disorders such as hypertension, cardiovascular diseases and sleepiness-related accidents. Treatment modalities for OSAHS at the present time include nasal continuous positive airway pressure( CPAP) , surgery option and oral appliances. However many patients refuse or cannot tolerate CPAP and surgery treatment and randomized trials report patient preference for o-ral appliances. Today, the most commonly used oral appliances are the mandibular advancement devices (MADs). This article provides an overview of OSAHS: its epidemiology, clinical features, diagnosis and clinical application on treatment of OSAHS with MADs.

Bite force and sleep quality in patients with bruxism before and after using a mandibular advancement device / Força de mordida e qualidade do sono em pacientes bruxômanos antes e após o uso de placa de avanço mandibular

Purpose: This study aimed to compare bite force and sleep quality in patients with bruxism before and after using a soft mandibular advancement device. Methods: Eighteen patients with bruxism attending the Occlusion Clinics of the PUCRS Dental School were selected according to the study eligibility criteria, examined according to the RDC/DTM protocol, and treated with a soft mandibular advancement device. Before the treatment and after 30 days the subjects were tested for: maximal bite force with a cross-arch force transducer placed in the first molar region, sleep quality assessed by means of the University of Toronto Sleep Assessment Questionnaire (SAQ), and number of masseter muscle contractions during sleep measured with the adhesive BiteStrip®. Data were analyzed by Student t tests, Wilcoxon tests, and McNemar tests at a significance level of 0.05. Results: After 30 days using the mandibular advancement device there was a significant decrease in some bruxism parameters, bite force, and total SAQ score (P < 0.05). Conclusions: The results suggest that the use of a soft mandibular advancement device for one month reduced bite force and bruxism and improved sleep quality in this sample.

Objetivo: Comparar a força de mordida e a qualidade do sono em pacientes com bruxismo antes e depois do uso de uma placa de avanço mandibular resiliente. Metodologia: Dezoito pacientes com bruxismo em atendimento na Clínica de Oclusão da Faculdade de Odontologia da PUCRS foram selecionados de acordo com os critérios de eligibilidade do estudo, examinados segundo o protocolo RDC/DTM e tratados com uma placa de avanço mandibular resiliente. Antes e após 30 dias de uso da placa de avanço mandibular os sujeitos foram submetidos a testes de força máxima de mordida com um transdutor de força compressiva de arco cruzado posicionado na região de primeiro molar; de qualidade do sono, de acordo com o questionário QAS da Universidade de Toronto; e de contagem do número de contrações do músculo masseter durante o sono usando-se o adesivo BiteStrip®. Os dados foram analisados por teste t de Student, teste de Wilcoxon e teste de McNemar ao nível de significância de 0,05. Resultados: Houve diminuição significativa (P < 0,05) dos parâmetros de bruxismo, de força de mordida e do escore total do QAS após o uso da placa de avanço mandibular por 30 dias. Conclusão: Os resultados sugerem que o uso da placa de avanço mandibular resiliente por um mês reduziu a força de mordida e o bruxismo e melhorou a qualidade do sono nesta amostra.

Therapeutic Effect of Mandibular Advancement Device in Sleep-Related Breathing Disorders

BACKGROUND: The Mandibular advancement device (MAD) was known to be one of the effective treatments for the broad spectrum of sleep related breathing disorders. The aim of the present study was to evaluate the therapeutic effects and the determinants of success or failure of MAD in patients with sleep-related breathing disorders (SRBD). METHODS: We enrolled 20 patients with SRBD confirmed by overnight polysomnography. All patients were fitted with temporary MAD. Apnea-hypopnea index (AHI) and risk index (RI) were measured by a portable respiratory- monitoring device (MESAM IV) before and after temporary MAD use. RESULTS: Overall, MAD significantly reduced AHI (18.9+/-11.6/hr to 13.8+/-11.9/hr, p=0.029), but Epworth sleepiness scale was not improved (10.9+/-3.9 to 9.8+/-3.9, p=0.086). More than 50% of reduction in AHI was observed in 6 patients (30%, 6/20). When subjects were divided into patients who were satisfied with the temporary MAD and decided to keep wearing permanent MAD during the night (good response, GR, N=12) and patients who refuse to wear permanent MAD because they could not get accustomed to the temporary MAD (poor response, PR, N=8), There were no differences in age, body mass index, and pre-treatment AHI during the overnight polysomnography between both groups. There were significant reductions in AHI, and ESS were observed in GR, not in PR. Seven patients in GR group decided to apply the permanent MAD (two-piece Herbst type). CONCLUSIONS: These findings suggested that having good response to MAD determined the improvement of SRBD and daytime sleepiness. However, it is uncertain whether other factors affected the patients' compliance to MAD.