ABSTRACT
Abstract Objective Few studies analyzed the safety of salvage nipple-sparing mastectomy (NSM) for local relapse treatment. We evaluated the outcomes of patients with indications for mastectomy who chose to undergo NSM for ipsilateral breast tumor recurrence (IBTR). Methods Between January 2001 and December 2018, we evaluated 24 women who underwent NSM for local relapse after conservative surgery. Results Thepatientswere followedupfor amean time of132months since thefirst surgery. After the NSM, 5 (20.8%) patients were diagnosed with local recurrence and only 1 (4.2%) patient died. The patients presented 4.8% (2) of partial and 2.4% (1) of total nipple necrosis. Conclusion In this long-term follow-up since the first surgery, we observed low rates of complication and good survival, although associated with high local recurrence in patients diagnosed with IBTR undergoing NSM as salvage surgery.We demonstrated that NSMmay be considered after IBTR for patients who did not want to undergo total mastectomy.
Resumo Objetivo Há poucos estudos sobre a segurança de se realizar adenomastectomia (nipple-sparing mastectomy, NSM, em inglês) para tratamento de recidiva local. O objetivo deste estudo foi avaliar os resultados de pacientes com indicação para mastectomia que optaram por se submeter a NSM para o tratamento de recorrência local. Métodos Foram analisadas 24 pacientes submetidas a NSM para tratamento de recidiva local após tratamento conservador entre janeiro de 2001 e dezembro de 2018. Resultados As pacientes foramacompanhadas por um períodomédio de 132meses a partir da primeira cirurgia. Após a NSM, 5 (20,8%) pacientes foram diagnosticadas com recorrência local, e apenas 1 paciente foi a óbito. As pacientes apresentaram 4,8% de necrose parcial e 2,4% de necrose total do mamilo. Conclusão Em um longo período de acompanhamento desde a primeira cirurgia, foram observadas baixas taxas de complicação pós-operatória e boa sobrevida, porém, associadas comuma alta taxa de recorrência local em pacientes submetidas a NSM para tratamento de recidiva local após cirurgia conservadora. Neste estudo, demonstrou-se que a NSM pode ser considerada uma opção cirúrgica para pacientes que não querem se submeter a mastectomia total.
Subject(s)
Humans , Female , Mastectomy, Segmental , Mastectomy, Subcutaneous , Neoplasm Recurrence, LocalABSTRACT
Breast cancer is a health problem at international scale which has increased in the last years the morbility and mortality rates, it is thinks about that every 15 minutes a woman dies for this cause. Objectives: To value the results of the conservative and radical surgery in early stages of breast cancer. Method: A retrospective of case and control study was carried out, the sample was constituted by 30 patients, to those were applied conservative surgery and the same number with radical surgery in a five year-old period. Results: The survival for both groups to the 5 years was of 100 percent and the interval free of the disease behaved in a similar way in the conservative surgery and in the radical with 70,5 percent and 79,35 percent respectively. The perception of the corporal image as well as the sexual intercourses and couple, it presented bigger satisfaction in the conservatives. The radical surgery limits in more quantity the physical activity and the labor sphere that those that preserve their breast.Conclusions: We concluded that the conservative surgery is a favorable surgical option with similar interval free of the disease and global survival to the 5 years regarding to the radical surgery and a better quality of life.
El cáncer de mama es un problema de salud a escala internacional la cual ha aumentado en los últimos años las tasas de morbilidad y mortalidad, se plantea que cada quince minutos fallece una mujer por esta causa. Objetivo: Valorar los resultados de la cirugía conservadora y radical en estadíos tempranos del cáncer de mama. Método: Se realizó un estudio retrospectivo de casos y controles, la muestra estuvo constituida por treinta pacientes, a las que se le aplicó cirugía conservadora e igual número con cirugía radical en un período de cinco años. Resultados: La supervivencia para ambos grupos a los cinco años fue de un 100 por ciento y el intervalo libre de enfermedad se comportó de forma similar en la cirugía conservadora y en la radical con un 70,5 por ciento y un 79,35 por ciento respectivamente. La percepción de la imagen corporal así como las relaciones sexuales y de pareja, presentó mayor satisfacción en las conservadoras. La cirugía radical limita en mayor cuantía la actividad física y la esfera laboral que las que preservan la mama. Conclusiones: Se concluyó que la cirugía conservadora es una opción quirúrgica favorable con similar intervalo libre de enfermedad y supervivencia global a los cinco años con respecto a la cirugía radical y una mejor calidad de vida.
Subject(s)
Humans , Female , Breast Neoplasms , General SurgeryABSTRACT
En países en vías de desarrollo, el cáncer de mama se presenta en estados localmente avanzados en la mitad de los casos. El manejo de estas pacientes se hace a partir de la combinación de quimioterapia, cirugía y radioterapia. La quimioterapia neoadyuvante posibilita la cirugía conservadora con relativa frecuencia, aunque esta aproximación terapéutica no se considera todavía una práctica estándar. No hay recomendaciones claras acerca del uso del refuerzo con radioterapia en este escenario. Se realizó una búsqueda de literatura relevante en Medline. La mayoría de artículos correspondieron a series de casos. La supervivencia libre de recaída loco-regional entre pacientes tratadas con quimioterapia neoadyuvante, cirugía conservadora y radioterapia sobre campos tangenciales asociada a un refuerzo localizado sobre el lecho tumoral es buena. El refuerzo se administró de manera sistemática a todas las pacientes sin considerar factores pronósticos diferentes del estado localmente avanzado. Aunque la evidencia no es de primer nivel, permite recomendar el uso sistemático del refuerzo en pacientes con tumores localmente avanzados de mama tratados con cirugía conservadora.
Nearly half of breast cancer patients in developing countries present with a locally advanced cancer. Treatment is centered on a multimodal approach based on chemotherapy, surgery and radiotherapy. The growing use of neoadjuvant chemotherapy has led to a more conservative surgical approach; nonetheless, it is not yet considered as a standard. There are no clear recommendations on the use of a radiotherapy boost in such situation. A Medline search was developed. Most articles are retrospective series. Survival free of locoregional relapse in patients treated with neoadjuvant chemotherapy, breast conserving surgery and radiotherapy is good. All articles described a boost administered to nearly all patients without regard to their prognostic factors, given that a locally advanced tumor is already considered as a poor prognostic factor. Even tough the poor level of evidence, a recommendation can be made: radiotherapy boost should be administered to all patients with locally advanced breast cancer treated with neoadjuvant chemotherapy and breast conserving surgery.