ABSTRACT
La mastopatía diabética es una lesión fibroinflamatoria de la mama muy infrecuente, que característicamente se presenta en mujeres premenopáusicas y está fuertemente asociada a diabetes mellitus tipo I. La patogénesis es desconocida, sin embargo, histopatológicamente se ha observado una reacción en el tejido conectivo similar al de algunas enfermedades autoinmunes. La clínica y exámenes complementarios pueden ser sugerentes de neoplasia, por lo que se requiere estudio histopatológico para establecer el diagnóstico definitivo.
Diabetic mastopathy is a very infrequent fibro-inflammatory lesion generally found in pre-menopausal women and is strongly associated with type 1 diabetes mellitus. Its pathogenesis is unknown; however its histopathology shows a connective tissue reaction similar to that of some auto-immune diseases. Its clinical presentation and complementary tests may suggest neoplasm, thus definitive diagnosis requires a histopathological study.
Subject(s)
Humans , Female , Middle Aged , Breast Diseases/diagnosis , Breast Diseases/etiology , Breast Diseases/therapy , Diabetes Mellitus, Type 1/complicationsABSTRACT
Antecedentes. La diabetes mellitus produce microvasculitis y alteración histoarquitectural de la mama. Se encuentra en el 1% de la mastopatía benigna. Sin embargo, la distorsión del parénquima produce sintomatología inflamatoria clínicamente similar a las mastopatías inflamatorias infecciosas. Su diagnóstico imagenológico es, a su vez, de gran dificultad interpretativa. Estos parámetros inespecíficos desembocan en tratamientos que no logran eficacia en la enfermedad, más aún si se ignora el contexto de la enfermedad de origen, la cual es sistémica. Objetivos. Destacar la importancia del diagnóstico diferencial de esta infrecuente entidad patológica. Material y Métodos. Se revisaron historias clínicas de un servicio de mastología por el término de seis meses a efectos de recabar información estadística. Población. Se estudiaron dos pacientes en un universo de más de cien historias clínicas abordadas. Resultados. Histológicamente, estas pacientes presentaron rasgos microscópicos que consisten en una lobulitis linfocitaria que afecta al epitelio y gran vasculitis edematosa. El diagnóstico histológico es crucial para llegar al tratamiento. Discusión y conclusiones. La mastopatía de las pacientes diabéticas insulinodependientes es la manifestación crónica de eventos sistémicos, producida en un porcentaje muy bajo de pacientes con la enfermedad. La correcta interpretación clínica y mamográfica, además de la sospecha semiológica, desembocan en el adecuado tratamiento de esta enfermedad inserta en un contexto sistémico.
Background. Diabetes mellitus occurs histoarquitectural microvasculitis and alteration of the breast. It is found in 1% of benign breast disease. However, distortion occurs parenchymal inflammatory symptoms clinically similar to infectious inflammatory breast disease. Its diagnostic imaging is in turn highly interpretive difficulty. These nonspecific parameters lead to effective treatments that fail in the disease, especially if the context of disease origin is unknown, which is systemic. Objectives. To highlight the importance of the differential diagnosis of this rare disease entity. Material and methods. Clinical histories mastology service for a period of six months for the purpose of collecting statistical data were reviewed. Population. Two patients were studied in a universe of more than one hundred medical records addressed. Results. Histologically, these patients had microscopic features consisting lobulitis lymphocytic affecting large edematous epithelium and vasculitis. Histological diagnosis is crucial to get the treatment. Discussion and conclusions. Diabetic mastopathy in insulin dependent patients is chronic manifestation of systemic events produced in a very low percentage of patients with the disease. The correct clinical and mammographic interpretation, in addition to lead to suspicion semiológica proper treatment of this disease, inserted in a systemic context.
Subject(s)
Humans , Female , Adult , Diabetes Complications , Breast Diseases/diagnosis , Diagnosis, Differential , Breast/pathology , Breast Neoplasms/diagnosisABSTRACT
A mastopatia linfocítica acomete mulheres jovens e de meia idade e está frequentemente associada a doenças autoimunes. Seu diagnóstico é feito associando achados clínicos (espessamento ou nódulo mamário endurecido), radiológicos (aumento da densidade mamária, nódulo e calcificações), ultrassonográficos (nódulo com sombra acústica posterior), histopatológicos (fibrose e infiltrado linfocítico) e imuno-histoquímicos. É uma entidade benigna que pode simular carcinoma. Neste artigo, relata-se um caso de paciente com mastopatia linfocítica.
Lymphocytic mastopathy affects both young and middle-aged women and is frequently associated with autoimmune diseases. Diagnosis is done by associating clinical (breast tissue thickening or hardened breast lump), radiological (increased breast density, presence of mass and calcifications), sonographic (nodule with posterior acoustic shadowing), histopathological (fibrosis and lymphocytic infiltrate) and immunohistochemical findings. Lymphocytic mastopathy is a benign entity that may mimic carcinoma. The authors report the case of a patient with lymphocytic mastopathy.
ABSTRACT
Diabetic mastopathy is an unusual fibroinflammatory breast lesion that is characteristically presented in premenopausal women with long-standing diabetes with multiple microvascular complications. This patient was a 49-year-old postmenopausal woman with diabetic nephropathy, neuropathy, and retinopathy. Although palpable mass was detected on the left breast, an ultrasonography could not distinguish it from breast cancer. Excisional biopsy was conducted. Histological findings indicated diabetic mastopathy with keloid-like fibrosis, perivascular lymphocytic infiltration, and lymphocytic lobulitis without evidence of malignancy. After excision, there has been no recurrence until now.
Subject(s)
Female , Humans , Middle Aged , Biopsy , Breast , Breast Neoplasms , Diabetic Nephropathies , Fibrosis , RecurrenceABSTRACT
Objective: To retrospectively analyze the clinical records and imaging data of patients with diabetic mastopathy according to pathological findings of samples obtained by histological puncture with ultrasound guidance. Methods: Between 2002 and 2007, six patients were diagnosed with diabetic mastopathy, and their medical records and MR images were assessed. All patients underwent both mammography and ultrasound examination. One of them was additionally submitted to MRI. Results: The patients' mean age was 36.6 years. Mammograms showed asymmetric tissue densifications without micro calcifications, while ultrasound examination evidenced ill-defined solid nodular or pseudonodular areas greater than 2 cm, with posterior sonic attenuation. Magnetic resonance imaging revealed a nodular area with poorly defined contours with enhancement similar to normal breast tissue. By performing eco-guided biopsy, it was possible to establish the differential histological diagnosis of breast carcinoma and to confirm diabetic mastopathy. Conclusion: Diabetic mastopathy presents mammographic and ultrasound imaging features indistinguishable from breast cancer. Since MRI does not reveal pathological stromal enhancement it can be helpful for a differential diagnosis. The echo-guided biopsy allows the diagnosis of this condition.
Objetivo: Analizar retrospectivamente las historias clínicas e imágenes de pacientes conmastopatía diabética, según hallazgos en anatomía patológica de muestras obtenidas por punción histológica con guía ecográfica. Material y Métodos: Entre los años 2002 y 2007, se diagnosticaron 6 pacientes con mastopatía diabética, evaluándose sus historias clínicas e imágenes. A todas las pacientes se le efectuó mamografía y ecografía; a una paciente se realizó además resonancia magnética. Resultados: La edad promedio de las pacientes fue de 36,6 años. Las mamografías mostraron densificaciones tisulares asimétricas sin microcalcificaciones; las ecografías evidenciaron áreas sólidas nodulares o seudonodulares mal definidas, mayores a 2 cm, con atenuación sónica posterior y la resonancia magnética: un área nodular de contornos mal delimitados con realce similar al tejido mamario normal. La punción biopsia ecoguiada pudo establecer el diagnóstico histológico diferencial con carcinoma mamario y confirmar mastopatía diabética. Conclusión: La mastopatía diabética presenta características imaginológicas en mamografía y ecografía que pueden ser similares al carcinoma. La resonancia magnética, al no presentar realce patológico estromal, puede colaborar en el diagnostico diferencial. La biopsia eco-guiada permite el diagnóstico de esta patología.
Subject(s)
Humans , Carcinoma/diagnosis , Diabetes Mellitus, Type 1/complications , Fibrocystic Breast Disease/diagnosis , Breast Neoplasms/diagnosis , Biopsy, Needle , Carcinoma/pathology , Diagnosis, Differential , Retrospective Studies , Magnetic Resonance Imaging , Mammography , Breast Neoplasms/pathologyABSTRACT
A mastopatia diabética acomete mulheres na pré-menopausa com diabetes mellitus tipo 1 de longa data. Seu diagnóstico é feito associando achados clínicos (espessamento ou nódulo mamário endurecidos, uni ou bilateral), radiológicos (aumento da densidade mamária), ultra-sonográficos (acentuada sombra acústica posterior) e histopatológicos (fibrose e infiltrado linfocítico perivascular e periductal). Pode simular carcinoma. Neste artigo relata-se um caso de paciente com mastopatia diabética.
Diabetic mastopathy affects premenopausal women with longstanding type 1 diabetes mellitus. The diagnosis is based on clinical findings (uni or bilateral hardened, palpable mass) associated with radiological (increase in breast density), sonographic (marked posterior acoustic shadowing), and histopathological (fibrosis and perivascular and periductal lymphocytic infiltration) findings. This disease may clinically simulate a breast carcinoma. The case of a patient with diabetic mastopathy is reported.
Subject(s)
Humans , Female , Adult , Diabetes Mellitus, Type 1 , Diabetes Mellitus, Type 1/complications , Fibrocystic Breast Disease/etiology , Breast Diseases/diagnosis , Breast Diseases/pathology , Breast/pathology , Breast Neoplasms/diagnosis , Biopsy, Fine-Needle , Diagnosis, DifferentialABSTRACT
Fibrous mastopathy, also known as diabetic mastopathy and lymphocytic mastopathy, may mimic breast cancer at the physical examination, mammography, and ultrasound. We report a case of a woman who presented a non-tender mass clinically suggestive of breast carcinoma; however, the fine-needle aspiration cytology indicated atypia and the core needle biopsy revealed lymphocytic mastopathy. The magnetic resonance imaging of the breast showed a lesion with benign features. It was not demonstrated diabetics mellitus and autoimmune diseases. The patient got pregnant, breastfed, and it was observed the progressive regression of the lesion, with complete disappearance of the solid mass. Three years and three months later, there was no palpable mass at the clinical examination and ultrasound. In conclusion, fibrous mastopathy shall be considered for all breast lesions, regardless of the diagnosis of diabetes mellitus. Once a definitive diagnosis of this pathology is reached, it is recommended clinical, imaging studies and fine-needle aspiration biopsy follow-up of the patient, avoiding unnecessary surgical procedures.
A mastopatia fibrótica, também conhecida como mastopatia diabética e mastopatia linfocítica, pode, ao exame clínico, mamografia e ultra-som, simular um carcinoma mamário. Descrevemos o relato de uma mulher na qual o nódulo foi inicialmente suspeito de carcinoma mamário, mas o diagnóstico pela punção aspirativa com agulha fina foi de atipia, e o com biópsia com agulha grossa foi de mastopatia linfocítica. A ressonância magnética da mama mostrou a lesão com características de benignidade. Não foram demonstradas diabetes mellitus e doenças auto-imunes. A paciente engravidou, amamentou e foi observada regressão progressiva da lesão, com desaparecimento da mesma. A paciente persiste sem lesão na mama ao exame clínico e de ultra-som após acompanhamento de três anos e três meses. Em conclusão, a mastopatia fibrótica deve ser considerada para todas as lesões de mama, mesmo em pacientes sem diabetes mellitus. Quando o diagnóstico definitivo da patologia for realizado, é recomendável o acompanhamento da paciente com estudos clínicos e de imagem e biópsia com agulha fina, evitando-se procedimentos cirúrgicos desnecessários.
Subject(s)
Adult , Female , Humans , Breast Neoplasms/pathology , Breast/pathology , Carcinoma, Lobular/pathology , Fibrocystic Breast Disease/pathology , Biopsy, Needle , Breast Feeding , Breast Neoplasms/surgery , Breast/surgery , Carcinoma, Lobular/surgery , Diagnosis, Differential , Diabetes Mellitus/diagnosis , Fibrocystic Breast Disease/surgery , Mammography , Ultrasonography, MammaryABSTRACT
Objetivo: relatar um caso de mastopatia diabética bilateral, um tipo incomum e raro de doença inflamatória da mama. A associação entre mastopatia e diabete insulino-dependente é uma condição não muita conhecida. Relato do caso: paciente do sexo feminino, trinta e dois anos de idade, com diagnóstico de diabete desde os doze anos. A investigação clínica se baseou na anamnese e exame físico; realizada, também, ultra-sonografia e histopatologia. Considerações finais: o caso apresentado demonstra a importância do diagnóstico precoce das doenças que afetam a mama e a gravidade da mastopatia diabética, quando detectada tardiamente.
Objective: to report a case of diabetic mastopathy, an uncommon type of inflammatory breast pathology. The bilateral form is more rare. The association between mastopathy and insulin-dependent diabetes is a not very known condition. Case report: patient of female sex, thirtytwo years old, with diagnoses of diabetes at age of twelve. Final considerations: in the case reported above the authors emphasize the importance of early diagnosis in breast diseases.
Subject(s)
Humans , Female , Adult , Diabetes Mellitus, Type 1/complications , Breast Diseases/diagnosis , Breast/pathologyABSTRACT
A mastopatia diabética é uma doença rara fibroinflamatória da mama, decorrente da reação auto-imune de acúmulo anormal de proteínas de matriz, causada pela hiperglicemia. Ocorre em pacientes diabéticas de longa data, principalmente as do tipo 1 e que se encontram na pré-menopausa. Aqui se relata um caso de mastopatia diabética em uma mulher de 71 anos de idade, com história de diabetes melito tipo 2, insulino-dependente, de 20 anos de duração, que tinha sido submetida a uma cirurgia plástica mamária aos 35 anos de idade. O exame físico mostrava uma massa endurecida, pouco definida e móvel no quadrante inferior externo, medindo 2 cm. Não possuía expressão mamográfica ou ultra-sonográfica. A biópsia excisional do nódulo e subseqüente exame histopatológico revelaram lobulite linfocítica esclerosante ou mastopatia diabética. O exame clínico pode mimetizar neoplasia maligna de mama e o diagnóstico histopatológico deve ser obrigatório para diagnóstico diferencial.
Diabetic mastopathy is a rare fibroinflammatory breast disease decurrent of autoimmune reaction to the accumulation of abnormal matrix proteins, caused by hyperglycemia. It occurs in long-standing insulin dependent, mainly with type I diabetes, and pre-menopause patients. We present a case of diabetic mastopathy in a 71-year-old woman with a history of insulin-dependent diabetes mellitus type 11 of 20 years duration who has done a mammary plastic surgery. Physical examination showed a stony-hard, ill-defined but freely movable mass at lower outer quadrant measuring 2 cm. It didn't have mammographic netheir ultrassonographic findings. Excisional biopsy of the nodule was performed and the histopathological examination of the lesion revealed sclerosing lymphocitic lobulitis or diabetic mastopathy. Clinical and ultrassonographic exams mimic breast cancer and for this reason the histological diagnosis must be useful for deferential diagnosis.
Subject(s)
Humans , Female , Aged , Diabetes Mellitus, Type 1 , Fibrocystic Breast Disease/pathology , Biopsy, Needle , Diagnosis, Differential , Fibrocystic Breast Disease/diagnosisABSTRACT
Professor TANG Han-jun is a famous expert of traditional Chinese medicine,he has 50 years’experience in TCM. With the unique theories,rich clinical experience and excellent clinical effect,he has made great contributions to the surgery developmemnt of TCM. The article tries to summarize the essence of TANG Han-jun's clinical experience,as to show the regulation and characteristics and give introduction to the reader. Professor Tang indicates that essence-finding,selection of treamment based on the differential diagnosis and combination differentiation of symptoms and signs with differential diagnosis of disease are pivotial in mastopathy. The main way to administer medicines is enriching qi and nourishing spleen. Two typical cases of Herbal pastes(hyperplasia of mammary glands and mammary carcinoma) are presented.
ABSTRACT
Diabetic mastopathy is a rare disease that occurs in long-term insulin-dependent diabetic patient. It manifests as a hard palpable breast mass that may be clinically indistinguishable from a breast carcinoma. Mammography shows a non-specific, dense, heterogenous glandular opacity in both breasts. Sonography shows a markedly hypoechoic, ill-marginated mass with a posterior acoustic shadowing. We present the mammography, ultrasonography and MRI findings of a 54-year-old woman with diabetic mastopathy.
Subject(s)
Female , Humans , Middle Aged , Acoustics , Breast , Breast Neoplasms , Magnetic Resonance Imaging , Mammography , Rare Diseases , Shadowing Technique, Histology , UltrasonographyABSTRACT
Mortality rates for breast cancer in Japan have been increasing sharply. Earlier detection leading to early treatment is highly desirable. Despite improvement in imaging techniques for breast cancer, many cases with latent microcarcinoma go undetected each year. In Western medicine, diagnostic hormonal therapy with antiestrogens for mastopathy in order to induce latent carcinoma has been used successfully for diagnosis of such difficult cases. Antiestrogens, however, may cause intolerable side effects for some patients, and sometimes their administration must be stopped. Thus excisional biopsy is required for definitive diagnosis of malignancy. In oriental medicine, Keishi-bukuryo-gan has been shown to be effective for mastopathy and is considered quite safe. We examined it as an alternative to antiestrogens. Keishi-bukuryo-gan was administered to 116 patients out of 218 with mastopathy. In response, four were suspected to have breast cancer. All four were definitively diagnosed with breast cancer: two by fine-needle aspiration cytology, and two by excisional biopsy. Keishi-bukuryo-gan proved to be useful in diagnostic hormonal evaluation of mastopathy and diagnosis of breast cancer.
ABSTRACT
Diabetic mastopathy is a clinicopathologic entity which was first described as a dense fibrous breast mass in insulin-dependent diabetes mellitus. The purpose of this article was to document diabetic mastopathy histologically which had been diagnosed as fibrocystic disease and to avoid unnecessary surgical procedures in breast mass simulating malignancy in diabetic patients. We examined eight excisional breast biopsies from seven patients. Three diabetic patients with type I insulin-dependent diabetes mellitus presented with bilateral (2 patients) or unilateral (1 patient) rapidly growing palpable breast masses. Four patients with type II noninsulin-dependent diabetes mellitus presented with bilateral (2 patients) or unilateral breast mass (1 patient). One patient had no symptoms. All of them had late complications of diabetes mellitus such as nephropathy, neuropathy and retinopathy. Mammographic findings such as ill- defined mass density and asymmetric increased density suggested malignancy. However, all of them had been diagnosed as fibrocystic disease. On review, the most consistent pathologic finding was keloid-like stromal fibrosis. Others were ductitis or ductulitis, thickening of basement membrane of ducts or ductules, mononuclear perivasculitis and lobulitis. Six of eight breast satisfied all five criteria for diabetic mastopathy.
Subject(s)
Humans , Basement Membrane , Biopsy , Breast , Diabetes Complications , Diabetes Mellitus , Diabetes Mellitus, Type 1 , Diabetes Mellitus, Type 2 , FibrosisABSTRACT
Objective: Observing the effect of injecting 5- Fu into the mass of breast hyper-plasia. Methods: We randomly divide the 80 mastopathy patients into two groups ,40 patients ac-cepted the 5- Fu local injection (experiment group),and 40 patients taken orally rubixiaopian and ta-moxifen(control group). The clinical effects of the breast pain and breast lump were observed. Re-sults: The total effect of 5- Fu local injection into the lump of the mastopathy patients was 92.5 % , while control group was 75.0% , its difference was significant(P0.05)in the treatment of mastopathy lump. Conclusion: 5- Fu local injection had obvious effects to breast pain and breast lump of mastopathy.