ABSTRACT
Zika virus (ZV) is an arbovirus transmitted by Aedes aegypti and A. albopictus. The neurotropic profile of this virus is known since 1952. The main finding related to ZV in America is microcephaly. Two hypotheses are tested on its involvement in the central nervous system: its neurotropic feature and the direct effect of ZV on the placenta. Malformations and clinical findings on fetal development comprise congenital Zika syndrome. RT-PCR and serology (IgM) are useful for definitive diagnosis. However, we should keep in mind first that the viremia in pregnant women can stay for a longer period of time, and second, a positive IgM for Zika should be properly interpreted in an endemic area to other flavivirus. It is suggested to be part of TORCHS-Z complex the ZV infection in endemic areas.
El virus del Zika (VZ), arbovirus, es transmitido por Aedes aegypti y A. albopictus. Desde 1952 se conoce su perfil neurotrópico. El principal hallazgo relacionado con la infección en las Américas, es la microcefalia. Dos hipótesis se plantean sobre su afectación en el sistema nervioso central: su característica neurotrópica per se, y el efecto directo del virus sobre la placenta. Las malformaciones y hallazgos clínicos sobre el desarrollo fetal conforman el síndrome de Zika congénito. La reacción de polimerasa en cadena-transcriptasa reversa (RPC-TR) y serología (IgM) son útiles para el diagnóstico definitivo; sin embargo, debe tenerse en cuenta, primero, que la viremia en las mujeres embarazadas puede permanecer por un período más prolongado y segundo, que una IgM positiva para Zika, debe ser adecuadamente interpretada en un medio endémico para otros flavivirus. Se propone a la infección por el VZ, en zonas endémicas, como parte del complejo TORCHS-Z.
Subject(s)
Humans , Animals , Female , Pregnancy , Pregnancy Complications, Infectious/virology , Zika Virus Infection/complications , Zika Virus Infection/diagnosis , Zika Virus Infection/virology , Microcephaly/virology , Pregnancy Complications, Infectious/diagnosisABSTRACT
Measles during pregnancy has been associated with deleterious effects on the perinatal outcomes. We encountered a case of perinatal measles infection during the 2013 measles outbreak in South Korea. The mother experienced severe gestational measles associated with the lack of vaccination. She had a preterm delivery and the neonate developed congenital measles, which was diagnosed based on the results of serological tests for the mother and neonate. Herein, we described the case, first reported with confirmed transplacental transmission in Korea to our best knowledge, and also reviewed relevant literature regarding measles during pregnancy, which suggested that perinatal measles and the outcomes are markedly influenced by the status of maternal immunity during prenatal period.