Injerto de hueso calvarial envuelto en colgajo pediculado de fascia temporo-parietal para reconstrucción de reborde cigomático-maxilar e infraorbitario: reporte de caso / Calvarial bone graft wrapped in temporo-parietal fascia pedicled flap for zygomatico-maxillary and infraorbital rim reconstruction: case report

La reconstrucción posterior a una cirugía oncológica resectiva maxilar es todo un desafío. Debido a esto, existen diversas técnicas quirúrgicas cuyo objetivo apunta a mantener no solo la funcionalidad, sino también la estética facial, especialmente en el área del reborde infraorbitario. El injerto de hueso calvarial es una opción segura y versátil para realizar una reconstrucción primaria en el reborde infraorbitario. Esta técnica está indicada en aquellos pacientes en los cuales la resección cutánea y exenteración orbitaria no son necesarias. Por este motivo, a continuación, analizaremos este tipo de injerto a propósito de un caso clínico en el que se usó asociado a un colgajo pediculado de fascia temporoparietal.

Reconstruction after maxillary resective oncological surgery is a challenge. Because of this, there are many surgical techniques whose objective is to maintain not only function but also facial aesthetics, especially in the infraorbital rim area. The calvarial bone graft is a safe and versatile option to perform a primary infraorbital rim reconstruction. This technique is indicated in those patients in whom skin resection and orbital exenteration are not necessary. For this reason, we will now analyze this type of graft in relation to a case in which it was used associated with a temporo-parietal fascia flap.

Colgajo temporal en la reconstrucción de un defecto maxilar por exéresis de carcinoma ameloblástico / Temporalis muscle flap in the reconstruction of a maxillary defect caused by exeresis of ameloblastic carcinoma

RESUMEN Introducción: El carcinoma ameloblástico es una entidad rara que surge como una neoplasia primaria o a partir de un ameloblastoma preexistente. El colgajo de músculo temporal es una opción terapéutica frecuentemente empleada para la reconstrucción del defecto resultante luego de la exéresis quirúrgica. Objetivo: Presentar un caso clínico de restauración estética y funcional mediante reconstrucción con colgajo temporal de un defecto maxilar por exéresis de carcinoma ameloblástico, dada la infrecuente presentación de esta entidad. Caso clínico: Mujer de 49 años de edad, que refiere "una bola" en el paladar de 9 meses de evolución. Al examen físico facial presenta aumento de volumen en región infraorbitaria izquierda. Se realizó una tomografía axial computarizada en la que se constató la presencia de imagen hiperdensa en seno maxilar izquierdo con calcificación en su interior, produciendo lisis del hueso nasal y hueso cigomático infiltrando partes blandas. Se tomó muestra para biopsia que informó tumor de alto grado de malignidad correspondiente a carcinoma ameloblástico. En estudio radiográfico de tórax no se apreció presencia de metástasis pulmonar. Se realizó maxilarectomía de infra y mesoestructura, resección de la lesión con margen oncológico de seguridad y se reconstruyó el defecto palatino con colgajo pediculado del músculo temporal. Se indicó quimio y radioterapia como terapia adyuvante al tratamiento quirúrgico. Se mantuvo el chequeo posoperatorio mostrándose buena evolución clínica y una epitelización secundaria del músculo temporal en el área palatina con restauración de las funciones. Conclusiones: Se presentó un caso clínico de carcinoma ameloblástico, entidad patológica de escasa frecuencia. La cirugía constituyó el pilar de tratamiento utilizado. Una vez realizada la resección quirúrgica se reconstruyó el defecto palatino, utilizándose el colgajo del músculo temporal, opción útil para lograr el restablecimiento de las funciones estéticas y funcionales como la deglución y fonación(AU)

ABSTRACT Introduction: Ameloblastic carcinoma is a rare condition emerging as a primary neoplasm or from a preexisting ameloblastoma. Temporalis muscle flap is a therapeutic option frequently used for reconstruction of the defect resulting from surgical exeresis. Objective: Present a clinical case of esthetic and functional restoration by reconstruction with temporalis muscle flap of a maxillary defect caused by exeresis of an ameloblastic carcinoma. The case is presented because of the infrequent occurrence of this condition. Clinical case: A female 49-year-old patient reports "a lump" in her palate of nine months evolution. Physical examination finds an increase in volume in the left infraorbital region. Computed axial tomography was indicated, which revealed the presence of a hyperdense image in the left maxillary sinus with internal calcification causing lysis of the nasal bone and the zygomatic bone, and infiltrating soft tissue. A sample was taken for biopsy, which reported a tumor with a high degree of malignancy corresponding to ameloblastic carcinoma. Chest radiography did not show the presence of lung metastasis. Infra- and mesostructure maxillectomy was performed, the lesion was removed with a surgical safety margin, and the palatine defect was reconstructed with a pediculated temporalis muscle flap. Chemo- and radiotherapy were indicated as adjuvants to the surgical treatment. Postoperative follow-up found good clinical evolution and secondary epithelization of the temporalis muscle in the palatine area with restoration of functions. Conclusions: A clinical case was presented of ameloblastic carcinoma, a condition with a low frequency of occurrence. Surgery was the basic component of the treatment applied. Once surgical resection was performed, the palatine defect was reconstructed by means of a temporalis muscle flap, a useful option to achieve the restoration of esthetic and biological functions, such as swallowing and speech(AU)

Proteína morfogénica ósea en cirugía maxilofacial. Revisión bibliográfica / Bone morphogenic protein in maxillofacial surgery. Bibliographic review

El propósito de esta revisión es presentar una visión concreta de las proteínas morfogenéticas óseas, su potencial de inducir osteogénesis y la aplicación en los procesos regenerativos. Las investigaciones acerca de los iniciadores moleculares de diferenciación ósea y cartilaginosa han identificado un grupo entero de proteínas morfogenéticas óseas que ejercen efecto regulador. La proteína morfogenética ósea (BMP) es endógena, presenta propiedades osteoinductivas, osteoconductivas y osteogénicas, y ha mostrado efectos significativos en la promoción de la formación ósea, por lo cual es una buena alternativa en reconstrucción. El uso de BMP se ha descrito en la reconstrucción de los defectos óseos de origen traumático y patológico, incluyendo: fisura nasoalveolar, aumento del reborde alveolar, elevación del seno maxilar, injerto de alvéolo postextracción y cirugía peri-implantaria.

The purpose of this review is to present a concrete vision about bone morphogenetic proteins, their potential in the induction of osteogenesis and their application in regenerative processes. Research on the molecular primers of bone and cartilage differentiation has identified an entire group of bone morphogenetic proteins that exert a regulatory effect. The bone morphogenetic protein (BMP) is an endogenous protein, has osteoinductive, osteoconductive and osteogenic properties, has shown significant effects in the promotion of bone formation, being a good alternative in reconstruction. The use of BMP has been described in the reconstruction of bone defects of traumatic and pathological origin, including nasoalveolar fissure, increased alveolar ridge, maxillary sinus elevation, post-extraction alveolar graft, and perimplant surgery

Application of virtual surgical planning in maxillary and mandible reconstruction with fibula flap / 中华整形外科杂志

Objective@#To review the clinical data of patients who underwent maxillary and mandibular reconstruction with vascularized fibula osteomycutaneous flap, using virtual surgery planning.@*Methods@#From January 2012 to December 2016, 23 patients with mandibular defect and 2 patients with maxillary defect were treated in our department. In virtual surgery planning, the optimal osteotomy line and angle were designed. Segmental maxillectomy and mandibulectomy, as well as mandibular reconstruction were performed using guided templates to practice the virtual planning.Actual reconstruction results were compared with those of virtual surgery.@*Results@#Among the 25 patients, 2 patients were repaired with the ipsilateral fibula myocutaneous flap, 22 patients were lateral fibula myocutaneous flap. One case of maxillary type Ⅱd defect was repaired with left fibular muscle flap. All patients were followed up for 12 to 48 months. Satisfied bony unions and occlusion were observed in 25 patients.All patients reported excellent or good facial appearance. One of them received dental implants at 1 year postoperatively.@*Conclusions@#An ideal contour of maxilla and mandible can be obtained using vascularized fibula osteomycutaneous flap in virtual surgery.

Using virtual surgical planning for resection of jaw tumor and accurate reconstruction / 口腔疾病防治

Objective @#To review the patients who underwent accurate maxillary and mandibular reconstruction with vascularized osteomyocutaneous flap using virtual surgery and evaluate the postoperative results.@*Methods@# From June of 2009 to December of 2014, ninety-four patients were treated in our department. In virtual surgical planning, maxillectomy and mandibulectomy were simulated and donor site bone was superimposed mirror image of normal maxilla and mandible to complete accurate maxillary and mandibular reconstruction. Maxillectomy, mandibulectomy and bone reconstruction were performed using stereomodels and guided templates to replicate the virtual planning. Actual reconstruction result was compared with that of virtual surgery. The patients were asked to assess their satisfaction with facial appearance at 1 year postoperatively. @*Results@#Good bony unions and occlusion were observed in 94 patients. The actual results were basically in accordance with that of virtual surgery. The actual deviation between postoperative CT and preoperative virtual surgical planning was no more than 1 mm matched by computer software. All patients reported their facial appearance were excellent or good at 1 year postoperatively.@*Conclusion@#The ideal contour of neomaxilla and neomandible and good function with dental rehabilitation can be gained after accurate maxillary and mandibular reconstruction with vascularized osteomyocutaneous flap using virtual surgery.

Maxillary resection for cancer, zygomatic implants insertion, and palatal repair as single-stage procedure: report of three cases / 대한악안면성형재건외과학회지

BACKGROUND: Oronasal/antral communication, loss of teeth and/or tooth-supporting bone, and facial contour deformity may occur as a consequence of maxillectomy for cancer. As a result, speaking, chewing, swallowing, and appearance are variably affected. The restoration is focused on rebuilding the oronasal wall, using either flaps (local or free) for primary closure, either prosthetic obturator. Postoperative radiotherapy surely postpones every dental procedure aimed to set fixed devices, often makes it difficult and risky, even unfeasible. Regular prosthesis, tooth-bearing obturator, and endosseous implants (in native and/or transplanted bone) are used in order to complete dental rehabilitation. Zygomatic implantology (ZI) is a valid, usually delayed, multi-staged procedure, either after having primarily closed the oronasal/antral communication or after left it untreated or amended with obturator. The present paper is an early report of a relatively new, one-stage approach for rehabilitation of patients after tumour resection, with palatal repair with loco-regional flaps and zygomatic implant insertion: supposed advantages are concentration of surgical procedures, reduced time of rehabilitation, and lowered patient discomfort. CASES PRESENTATION: We report three patients who underwent alveolo-maxillary resection for cancer and had the resulting oroantral communication directly closed with loco-regional flaps. Simultaneous zygomatic implant insertion was added, in view of granting the optimal dental rehabilitation. CONCLUSIONS: All surgical procedures were successful in terms of oroantral separation and implant survival. One patient had the fixed dental restoration just after 3 months, and the others had to receive postoperative radiotherapy; thus, rehabilitation timing was longer, as expected. We think this approach could improve the outcome in selected patients.

Reabsorção de enxerto homógeno em reconstrução de maxila após 12 anos de acompanhamento ­ análise clínica, histológica e tomográfica / Resorption of allogeneic bone graft after 12 years of maxillary reconstruction ­ a clinical, histological, and tomographic follow-up analysis

Os enxertos ósseos homógenos provenientes de bancos de ossos podem ser utilizados para o tratamento de atrofias maxilofaciais em Odontologia. A disponibilidade e a menor morbidade ao paciente, assim como as altas taxas de sucesso observadas em um curto espaço de tempo, foram importantes fatores para a popularização da técnica, entretanto, existem poucos relatos na literatura com acompanhamentos longitudinais. Neste relato clínico, foi avaliada, por um período de 12 anos de carga funcional, uma restauração implantossuportada fixa sobre implantes inseridos em área regenerada com enxerto de banco homógeno, utilizando avaliação clínica e tomográfica. Ainda, é apresentado um breve relato histológico do tecido ósseo removido previamente à inserção dos implantes, sugerindo adaptação do material homógeno junto ao leito receptor. Após 12 anos de acompanhamento clínico, evidenciou-se, mesmo com o sucesso da restauração implantossuportada, a reabsorção total do enxerto homógeno, sugerindo que o mesmo não foi incorporado pelo tecido do hospedeiro. Nas limitações deste relato de caso, sugere-se que áreas enxertadas com osso homógeno devem ser reavaliadas com precaução devido ao grande potencial de reabsorção que podem apresentar, podendo assim comprometer a longevidade da restauração implantossuportada.

The allogeneic bone tissue bank can be used to treat maxillofacial atrophic sites. Its availability and less morbidity, as well as the higher success rates in a short-term period were important to popularize this technique; however, there are few literature reports with long-term results. In this case report, after 12 years of functional loading, a fixed implant-supported restoration was examined over a bone site regenerated with this graft type upon clinical and tomographic analyses. Also, a brief histological report from the removed tissue was presented before dental implant placement, suggesting the close ada ptation of the grafting material to the recipient site. After 12 years of clinical follow-up, even in the case of a successful implant-supported restoration, total graft resorption was demonstrated suggesting deficient incorporation to the recipient host site. Within the limitations of this case, it can be said that grafted areas with allogeneic bone must be evaluated with caution since there is a great chance of resorption, which can compromise the longevity of fixed restorations.

Maxillary Reconstruction Using rhBMP-2 and Titanium Mesh: Technical Note About the Use of Stereolithographic Model / Reconstrucción Maxilar Utilizando rhBMP-2 y Malla de Titanio: Nota Técnica sobre el Uso de Modelo Estereolitográfico

Maxillary reconstruction is a common procedure in maxillofacial surgery; for this purpose is used autogenous bone, alloplastic bone or another one with different results. In all of them, traditionally the use of computed tomography is used to make the surgical plan, however, 3D models are not used frequently. This report show a new application of the stereolithography to anticipate the surgical treatment of maxillary reconstruction, using a titanium mesh and rhBMP-2 to obtain a predictable surgical result with diminished surgical time.

La reconstrucción maxilar es un procedimiento común en cirugía maxilofacial; para este propósito es utilizado hueso autógeno, hueso aloplástico u otro tipo de hueso con diferentes resultados. En todos ellos, tradicionalmente el uso de tomografía computadorizada se emplea para elaborar el plan quirúrgico, sin embargo, los modelos 3D no son utilizados con frecuencia. Este reporte presenta una nueva aplicación de la estereolitografia para anticipar el tratamiento quirúrgico de la reconstrucción maxilar, usando una malla de titanio y rhBMP-2 para obtener un resultado quirúrgico predecible con disminución del tiempo quirúrgico.

A Case of Primary Reconstruction using Fibular Osteocutaneous Free Flap after Total Maxillectomy Due to Rhabdomyosarcoma

Rhabdomyosarcoma is a rare malignancy of head and neck region. When rhabdomyosarcoma occurs in maxillary area, total maxillectomy is necessary. Total maxillectomy causes defects of orbital floor, palate, gingiva, and alveolar bone, causing severe facial deformity and functional impairment. Immediate maxillary reconstruction has to cover both bone and soft tissue to minimize cosmetic and functional problems. The fibular osteocutaneous free flap can provide paranasal, gingiva, oral mucosal lining and foundation for dental prosthesis, thus ensuring good cosmetic results and mastication, phonation function. We have experienced a reconstruction case of a 19-year-old man with rhabdomyosarcoma of the left maxillary sinus. The patient underwent total maxillectomy and neck dissection. We designed a fibular free flap that had a vascularized bone segment and a double skin paddle. Surgical outcomes were excellent in cosmetic and functional aspects.

Functional reconstruction of dento-palatal and maxillary defect using staged operation of prefabricated scapular free flap and dental implants

The flap considered at first for the reconstruction of large maxillary defect, especially mid-face defect, is scapular free flap, because it provides ample composite tissue which can be designed 3-dimensionally for orbital, facial and oral reconstruction. In case of maxillary defect involving hard palate, however, this flap has some limitations. First, its bulk prevents oral function and physio-anatomic reconstruction of nasal and oral cavity. Second, mobility and thickness of cutaneous paddle covering the alveolar area reduce retention of tissue-supported denture and give rise to peri-implantitis when implant is installed. Third, lateral border of scapula that is to reconstruct maxillary arch and hold implants is straight, not U-shaped maxillary arch form. To overcome these problems, new concept of step prefabrication technique was provided to a 27-year-old male patient who had been suffering from a complete hard palate and maxillary alveolar ridge defect. In the first stage, scapular osteomuscular flap was elevated, tailored to fit the maxillary defect, particulated autologous bone was placed subperiosteally to simulate U-shaped alveolar process, and then wrapped up with split thickness skin graft(STSG, 0.3mm thickness). Two months later, thus prefabricated new flap was elevated and microtransferred to the palato-maxillary defect. After 6 months, 10 implant fixtures were installed along the reconstructed maxillary alveolus, with following final prosthetic rehabilitation. The procedure was very successful and patient is enjoying normal rigid diet and speech.